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Glen Ellyn, IL, United States

Maki K.C.,Provident Clinical Research Inc. | Buheiger D.N.,Solae LLC | Rains T.M.,Provident Clinical Research Inc. | Lawless A.L.,Provident Clinical Research Inc. | And 3 more authors.
Agro Food Industry Hi-Tech

Soy protein (SP) has well-described cholesterol-lowering effects, but the mechanisms responsible are not well [ understood. We conducted a trial that evaluated the effects of 25 g/d of an insoluble fraction of SP or total milk protein (TMP) on | fasting lipids and investigated the possible role of increased bile acid excretion in mediating these lipid responses. SP and TMP, I respectively, reduced total cholesterol (-7.4 and -3.6 percent), low-density lipoprotein cholesterol (LDL-C) (-10.9 and -5.9 percent), and non-high-density lipoprotein cholesterol (-10.8 and -3.9 percent), (p < 0.05 for between group differences except LDL-C, p = 0.085). Fecal bile acid and neutral sterol excretion were not increased with either protein source. These findings confirm that SP has a hypocholesterolemic effect, but this does not appear to be attributable to increased fecal bile acid excretion. Source

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