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Zorlutuna P.,Harvard-MIT Division of Health Sciences and Technology | Zorlutuna P.,University of Connecticut | Vrana N.E.,Harvard-MIT Division of Health Sciences and Technology | Vrana N.E.,Protip SAS | And 3 more authors.
IEEE Reviews in Biomedical Engineering | Year: 2013

The field of tissue engineering has been growing in the recent years as more products have made it to the market and as new uses for the engineered tissues have emerged, motivating many researchers to engage in this multidisciplinary field of research. Engineered tissues are now not only considered as end products for regenerative medicine, but also have emerged as enabling technologies for other fields of research ranging from drug discovery to biorobotics. This widespread use necessitates a variety of methodologies for production of tissue engineered constructs. In this review, these methods together with their non-clinical applications will be described. First, we will focus on novel materials used in tissue engineering scaffolds; such as recombinant proteins and synthetic, self assembling polypeptides. The recent advances in the modular tissue engineering area will be discussed. Then scaffold-free production methods, based on either cell sheets or cell aggregates will be described. Cell sources used in tissue engineering and new methods that provide improved control over cell behavior such as pathway engineering and biomimetic microenvironments for directing cell differentiation will be discussed. Finally, we will summarize the emerging uses of engineered constructs such as model tissues for drug discovery, cancer research and biorobotics applications. © 2008-2011 IEEE.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.20M | Year: 2014

Infections associated with dental implants may cause peri-implantitis often resulting in implant loss and impaired function. Recent studies show an alarming increase in the incidence of the infections, while on the other hand the efficacy of the prevailing treatment method is decreasing due to the rising resistance of micro-organisms to antibacterial agents. The SMEs of the NanoTi consortium intend to bring a new titanium implant to the market that possesses the innate capability to resist bacterial infections without the addition of any antibacterial compound. In order to reach this goal the aim of the NanoTi project is to develop nanophase topography on the surface of titanium dental implants that will enable such an effect. This nanophase topography: Reduces the susceptibility of titanium dental implants for infections; Enables the surgical decontamination of implants if infection occurs; Supports bone healing around the dental implant.

News Article | November 29, 2016

Between two extremes, there's usually a middle ground. Between small and large is medium, and in the case of headphones, on-ear headphones exist between over-ear and in-ear headphones. While similar to over-ear headphones in appearance, they fit to your head a little differently. Instead of enveloping your ears with a soft cushion, on-ear headphones create a light, breathable seal around your ear. Thus, the noise isolation is much less effective than in-ear or over-ear options but in exchange they breath a bit better than over-ears and sound better than in-ears. On-ear headphones are also usually more portable than their over-ear brethren, and as such they appeal to travellers and the fitness crowd. Taking a walk or a jog around town is also safer, as you can hear traffic go by and be aware of potential hazards. Check out our favorite picks below – you're sure to find something for every budget and style requirement. When you wear the B&O H2, people will look at you with intrigue, desperately trying to figure out who makes it so they can buy their own later online. I should know: it's how I found out about them. The H2 sounds as good as it look. The sound performance should please even picky listeners with its warm, evenly-balanced sound. We're trained to assume that good looks are a guise, but the H2's slick design complements the sound performance quite nicely. For your money, you can't do better than Grado's SR60e. The third-generation of the Brooklyn, NY-based company's Prestige Series is its best and most refined yet. The SR60e in particular is a smart choice if you're looking for an entry-level set of headphones that sounds like it should cost you way more than it does. Its open-backed ear cup design makes them a more breathable experience than what most on-ear headphones can deliver. Might be pricey for some Plantronics' BackBeat Sense is a home run on nearly all accounts. The design yields comfort and appeal. Its sound performance, battery life and features all deliver without a hitch. Usually, there are a few things that I'd like to see fixed in a set of headphones. In the case of the BackBeat Sense, I wish that the ear cups could fold into the headband to be ultra-portable. But for a set of headphones that gets so much right, I can't nitpick. These cans are worth every penny for someone looking to leap for a classy-looking set of wireless headphones. You, like everyone else, probably wants a set of headphones that nails the tricky blend of design, useful features and incredible sound. You might think that you need to flush your savings to enjoy such a pair of cans. Protip: you don't. The $99 Noontec Zoro II Wireless offer a warm and fun sound signature. With a 35-hour battery life and multipoint Bluetooth, these headphones offer an impressive value against more expensive competition. Klipsch has delivered on making a set of on-ear headphones that are perfect for music lovers looking for true, unbiased sound reproduction of their music. Not to mention that this is the most comfortable pair of on-ear headphones I've worn yet. While their design may not offer the most amount of flexibility, the awesome sound reproduction of the Klipsch Reference On-Ear make them one of the more versatile options for headphones and a fantastic value at that. The Solo 3 Wireless appear almost identical to the Solo 2 headphones from a quick glance. That being said, the majority of the changes Apple made to its class-leading cans come internally, baking its mobile phone know-how into these headphones to ramp-up their wireless skills and maximise battery life. In terms of wireless performance, these $299 (£249/AU$399.95) headphones are as reliable as any out there. However, you can get better sound quality at the price and, for just a little more, the Bose QuietComfort 35 offer much better comfort and active noise cancellation to make your work commute about 95 per cent more relaxing. The Bowers and Wilkins P5 Series 2 isn't the most feature-rich option, but in terms of sheer sound and build quality, they easily raise the bar for the competition to follow. These audiophile-grade headphones are a must-buy for anyone serious about hearing music the way it was intended. So long as you have the money, there's not much else in the on-ear market that can match this package at this price point. The Samsung Level On Pro Wireless are one of the few headphones I've tested that feel like they're meant as a package deal for another device. Yes they'll work with every Bluetooth and 3.5mm jack-equipped handset on the market, but you're better off sticking to a Samsung device in order to squeeze every ounce of aural goodness from the UHQ audio codec. It's one of the comfiest pair of cans on the market, and one of the best noise-cancelling, too. If it had a better sound quality for the vast majority of cell phone users it would be an easy recommendation but, as it stands, really makes the most sense at checkout when purchased alongside Samsung's Next Big Thing.

Kzhyshkowska J.,University of Heidelberg | Kzhyshkowska J.,Red Cross | Kzhyshkowska J.,Tomsk State University | Gudima A.,University of Heidelberg | And 6 more authors.
Journal of Leukocyte Biology | Year: 2015

Implants, transplants, and implantable biomedical devices are mainstream solutions for a wide variety of human pathologies. One of the persistent problems around nondegradable metallic and polymeric implants is failure of macrophages to resolve the inflammation and their tendency to stay in a state, named “frustrated phagocytosis.” During the initial phase, proinflammatory macrophages induce acute reactions to trauma and foreign materials, whereas tolerogenic anti-inflammatory macrophages control resolution of inflammation and induce the subsequent healing stage. However, implanted materials can induce a mixed pro/ anti-inflammatory phenotype, supporting chronic inflammatory reactions accompanied by microbial contamination and resulting in implant failure. Several materials based on natural polymers for improved interaction with host tissue or surfaces that release anti-inflammatory drugs/bioactive agents have been developed for implant coating to reduce implant rejection. However, no definitive, long-term solution to avoid adverse immune responses to the implanted materials is available to date. The prevention of implant-associated infections or chronic inflammation by manipulating the macrophage phenotype is a promising strategy to improve implant acceptance. The immunomodulatory properties of currently available implant coatings need to be improved to develop personalized therapeutic solutions. Human primary macrophages exposed to the implantable materials ex vivo can be used to predict the individual’s reactions and allow selection of an optimal coating composition. Our review describes current understanding of the mechanisms of macrophage interactions with implantable materials and outlines the prospects for use of human primary macrophages for diagnostic and therapeutic approaches to personalized implant therapy. © Society for Leukocyte Biology.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.3-2 | Award Amount: 7.47M | Year: 2013

IMMODGEL aims to identify adverse immune reactions to dental and larynx titanium implants and to develop a novel therapeutic strategy to significantly decrease the implant and medical device failure caused by these reactions via design of an innovative immunomodulatory system. The system will be designed to be fixed to an implant via an adhesive polyelectrolyte multilayer and control the immune response by autologous, phenotype modulated macrophages encapsulated in a hydrogel. The auxiliary nature of the design allows it to be adjusted to any implant, medical device or transplant. IMMODGEL will apply complex systems immunology, epidemiology, and functional approaches to identify key adverse immune reactions caused by implants and detrimental macrophage phenotypes around titanium implants. This will be used to establish the optimal biomaterial composition and cytokine delivery system for the immunomodulatory hydrogel design to revert macrophage-induced inflammatory reactions (M1) to the optimal tolerogenic and healing reactions (M2). Long-term fixation of the desired M2 phenotype will significantly decrease the level and duration of implant-induced inflammation, and optimise healing phase. The interaction of implants and medical devices with the immune system will be modelled to develop a Foreign Body Response on-a-chip to predict patients specific responses to implant materials and modify the immunomodulatory hydrogel accordingly, as a step towards personalized implants with minimal adverse reactions. The gels will be incorporated to engineered tissues for validation. Validation of the approach will be performed in vivo in animal models. Significantly suppressed inflammatory responses and optimal tissue remodelling and healing around titanium implants is expected. The key innovation will be the development of IMMODGEL as an auxiliary system to improve the outcomes of implantation and reduce the cost of implant complication and related medical costs in Europe.

Debry C.,Faculte Of Chirurgie Dentaireuniversite Of Strasbourg | Dupret-Bories A.,Hopitaux Universitaires Of Strasbourg | Vrana N.E.,Protip SAS | Hemar P.,Hopitaux Universitaires Of Strasbourg | And 2 more authors.
Head and Neck | Year: 2014

Background: Most patients perceive total laryngectomy as a mutilation carrying with it a loss of physical and psychological integrity. Thus, an artificial larynx system that can replace the laryngeal functions would significantly improve the quality of life for the afflicted patients. Methods: This report, with accompanying video, presents the first case in an ongoing clinical trial of laryngeal rehabilitation using an artificial larynx after total laryngectomy for squamous cell carcinoma, for an 8-month follow-up period. We depict the prosthesis' features, our 2-step surgical procedure, and the outcome. The prosthesis is formed of 2 parts: (1) a tracheal prosthesis with a porous titanium junction with trachea, which was implanted in the first step to ensure its colonization, and (2) a removable part composed of concentric valves that enable inhalation and exhalation. The second part was implanted endoscopically. The implant was monitored with a retrograde nasofibroscopy of the tracheal prosthesis lumen and CT scans over a course of 8 months. Results: The patient's functioning in the relevant postoperative problem areas, such as swallowing, breathing, and smelling, has significantly improved. The patient was able to talk in a whispering fashion while the tracheostomy was temporarily closed. The implant's porous part was in the process of being colonized by the surrounding tissue and no fistulas were observed as evidenced by barium swallow. Conclusion: As the current case shows, tracheotomy closure can be performed, and laryngeal functions are restored, by means of an implant. With further improvements, this system can alleviate the need for a permanent tracheostomy after total laryngectomy, while maintaining important larynx functions intact. © 2014 Wiley Periodicals, Inc.

Barthes J.,French Institute of Health and Medical Research | Ozcelik H.,French Institute of Health and Medical Research | Hindie M.,Cergy-Pontoise University | Ndreu-Halili A.,Epoka University | And 5 more authors.
BioMed Research International | Year: 2014

In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of the cells have a direct effect on cells' behaviour and subsequently on clinical outcomes. Physical, chemical, and biological control of cell microenvironment are of crucial importance for the ability to direct and control cell behaviour in 3-dimensional tissue engineering scaffolds spatially and temporally. In this review, we will focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities. The effect of these parameters on the cellular behaviour within tissue engineering context is discussed and how these parameters are used to develop engineered tissues is elaborated. Also, recent techniques developed for the monitoring of the cell microenvironment in vitro and in vivo are reviewed, together with recent tissue engineering applications where the control of cell microenvironment has been exploited. Cell microenvironment engineering and monitoring are crucial parts of tissue engineering efforts and systems which utilize different components of the cell microenvironment simultaneously can provide more functional engineered tissues in the near future. © 2014 Julien Barthes et al.

Protip SAS | Date: 2012-11-20

The invention relates to a medical device for supporting an implant or prosthesis, formed by two parts including one part forming an upper ring (1) which is made from a rigid or semi-rigid solid biocompatible material and another part forming a lower ring (2) which is made from a rigid or semi-rigid, integrable or porous biocompatible material, said device being intended to receive an implant or a removable prosthesis at the upper ring and to be installed in situ by means of the lower ring.

Protip SAS | Date: 2012-09-06

The present invention relates to the field of prosthetics having the function of restoring swallowing, breathing and phonation to a patient having a dysfunctional larynx. More specifically, the present invention concerns a valve device forming an intra-laryngeal endoprosthesis intended for implanting in the anatomical larynx in place having the function of enabling breathing while forming a seal against elements such as saliva, mucus or any other element coming from the bolus. The complete intra-laryngeal endoprosthesis, as well as its various applications, are also the subject matter of the present invention.

Protip Sas | Date: 2012-05-09

The present invention relates to a hybrid implant for the support and/or the replacement of tissue, a method for its preparation and its use. According to the invention, the hybrid implant is made of a polymeric scaffold combined with a mechanically stable template. It is particularly suitable for the disorders and pathologies where the support and/or the replacement of a tissue is necessary. The hybrid implant is particularly designed for cell colonization at a particular part of the implant or the whole implant, in order to restore the tissue functioning.

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