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News Article | May 16, 2017
Site: news.yahoo.com

WASHINGTON (AP) — President Donald Trump revealed highly classified information about Islamic State militants to Russian officials during a meeting last week, The Washington Post reported Monday, prompting strong condemnation from both Democrats and Republicans. Three White House officials who were in the May 10 meeting strongly denounced the story, saying no intelligence sources and methods were discussed — but they didn't deny that classified information was disclosed. Citing current and former U.S. officials, the Post said Trump shared details about an Islamic State terror threat related to the use of laptop computers on aircraft with Russian Foreign Minister Sergei Lavrov and Russian Ambassador to the U.S. Sergey Kislyak. The anonymous officials told the Post that the information Trump relayed during the Oval Office meeting had been provided by a U.S. partner through an intelligence-sharing arrangement. They said it was considered so sensitive that details have been withheld from allies and tightly restricted even within the U.S. government. "I was in the room, it didn't happen," H.R. McMaster, Trump's national security adviser, told reporters outside the White House late Monday. "The president and the foreign minister reviewed a range of common threats to our two countries including threats to civil aviation," McMaster said. "At no time, at no time were intelligence sources or methods discussed and the president did not disclose any military operations that were not already publicly known." He said Secretary of State Rex Tillerson and Dina Powell, deputy national security adviser for strategy, remember the meeting the same way. "Their on-the-record accounts should outweigh those of anonymous sources" in the news report, he said. Tillerson said Trump discussed a range of subjects, including "common efforts and threats regarding counter-terrorism." He said that during that exchange the nature of specific threats were discussed, but they did not discuss sources, methods or military operations. Powell said: "This story is false. The president only discussed the common threats that both countries faced." The Post story — which was later confirmed by The New York Times and BuzzFeed News — does not claim that Trump revealed any specific information about how the intelligence was gathered. Still, it will only heighten Trump's strained relations with intelligence workers and former officials, who view Russia as an adversary. Even before he was inaugurated, intelligence professionals worried about sharing classified information with Trump, who often shoots from the hip. If true, the breach was ill-timed, coming a day after Trump fired former FBI Director James Comey, who was leading an investigation into Russian meddling in the presidential election. Trump's first national security adviser, Michael Flynn, was fired after he misled Vice President Mike Pence about conversations he had with Kisylak. It's unlikely that Trump has broken any law. As president, Trump has broad authority to declassify government secrets. The Post said the intelligence partner had not given the United States permission to share the material with Russian officials. By doing so, Trump would have jeopardized cooperation from an ally familiar with the inner workings of the Islamic State group, and make other allies — or even U.S. intelligence officials — wary about sharing future top secret details with the president. Afterward, White House officials took steps to contain the damage, placing calls to the CIA and the National Security Agency, the newspaper said. The CIA and the Office of the Director of National Intelligence declined to comment Monday evening. Congressional Republicans and Democrats expressed concern about the report. GOP Sen. Bob Corker of Tennessee, chairman of the Senate Foreign Relations Committee, told reporters the Trump White House "has got to do something soon to bring itself under control and order." "The shame of it is there's a really good national security team in place and there are good, productive things that are under way through them and through others," Corker said. "But the chaos that is being created by the lack of discipline — it's creating an environment that I think makes — it creates a worrisome environment." Sen. John McCain, R-Ariz., chairman of the Senate Armed Services Committee, said that if the story is true it would be "deeply disturbing." Reaction from Democrats on the House and Senate intelligence committees was full-throated. Rep. Adam Schiff of California called the story "deeply disturbing" and said if it's true, the disclosure could jeopardize sources of very sensitive intelligence and relationships with key allies. "That the Russians would be the potential recipients of this intelligence and may be able to determine its source is all the more problematic, since the Russian interest in Syria and elsewhere is, in many respects, deeply antithetical to our own," Schiff said. He added that he wants the House intelligence committee fully briefed on what, if anything, was shared with the Russian officials. Sen. Mark Warner, D-Va., tweeted: "If true, this is a slap in the face to the intel community. Risking sources & methods is inexcusable, particularly with the Russians." The story prompted Sen. Martin Heinrich, D-N.M., to tweet: "Protip: Don't give the Russians classified information. #Classified101." Sen. Ron Wyden, D-Ore. — who had just had a root canal — read reporters a statement he scrawled out in the dentist's chair after learning about the story. "These reports, if true, are of the gravest possible concern. It could harm our national security by cutting off important sources of intelligence that protect Americans against terrorist acts," Wyden said. The controversy engulfed the White House. Reporters spent much of the evening camped out outside of Press Secretary Sean Spicer's office, hoping for answers. At one point, an eagle-eyed reporter spotted a handful of staffers, including Spicer and Deputy Press Secretary Sarah Huckabee Sanders, walking toward the Cabinet Room. Muffled yelling was heard coming from the area near the room, but after a reporter tweeted about the noise, press staffers quickly turned up their television volume, blasting the sound to drown out everything else. Associated Press writers Vivian Salama, Catherine Lucey, Jill Colvin, Ken Thomas, Richard Lardner and Mary Clare Jalonick contributed to this report.


Zorlutuna P.,Harvard-MIT Division of Health Sciences and Technology | Zorlutuna P.,University of Connecticut | Vrana N.E.,Harvard-MIT Division of Health Sciences and Technology | Vrana N.E.,Protip SAS | And 3 more authors.
IEEE Reviews in Biomedical Engineering | Year: 2013

The field of tissue engineering has been growing in the recent years as more products have made it to the market and as new uses for the engineered tissues have emerged, motivating many researchers to engage in this multidisciplinary field of research. Engineered tissues are now not only considered as end products for regenerative medicine, but also have emerged as enabling technologies for other fields of research ranging from drug discovery to biorobotics. This widespread use necessitates a variety of methodologies for production of tissue engineered constructs. In this review, these methods together with their non-clinical applications will be described. First, we will focus on novel materials used in tissue engineering scaffolds; such as recombinant proteins and synthetic, self assembling polypeptides. The recent advances in the modular tissue engineering area will be discussed. Then scaffold-free production methods, based on either cell sheets or cell aggregates will be described. Cell sources used in tissue engineering and new methods that provide improved control over cell behavior such as pathway engineering and biomimetic microenvironments for directing cell differentiation will be discussed. Finally, we will summarize the emerging uses of engineered constructs such as model tissues for drug discovery, cancer research and biorobotics applications. © 2008-2011 IEEE.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-2013-1 | Award Amount: 1.20M | Year: 2014

Infections associated with dental implants may cause peri-implantitis often resulting in implant loss and impaired function. Recent studies show an alarming increase in the incidence of the infections, while on the other hand the efficacy of the prevailing treatment method is decreasing due to the rising resistance of micro-organisms to antibacterial agents. The SMEs of the NanoTi consortium intend to bring a new titanium implant to the market that possesses the innate capability to resist bacterial infections without the addition of any antibacterial compound. In order to reach this goal the aim of the NanoTi project is to develop nanophase topography on the surface of titanium dental implants that will enable such an effect. This nanophase topography: Reduces the susceptibility of titanium dental implants for infections; Enables the surgical decontamination of implants if infection occurs; Supports bone healing around the dental implant.


News Article | November 29, 2016
Site: www.techradar.com

Between two extremes, there's usually a middle ground. Between small and large is medium, and in the case of headphones, on-ear headphones exist between over-ear and in-ear headphones. While similar to over-ear headphones in appearance, they fit to your head a little differently. Instead of enveloping your ears with a soft cushion, on-ear headphones create a light, breathable seal around your ear. Thus, the noise isolation is much less effective than in-ear or over-ear options but in exchange they breath a bit better than over-ears and sound better than in-ears. On-ear headphones are also usually more portable than their over-ear brethren, and as such they appeal to travellers and the fitness crowd. Taking a walk or a jog around town is also safer, as you can hear traffic go by and be aware of potential hazards. Check out our favorite picks below – you're sure to find something for every budget and style requirement. When you wear the B&O H2, people will look at you with intrigue, desperately trying to figure out who makes it so they can buy their own later online. I should know: it's how I found out about them. The H2 sounds as good as it look. The sound performance should please even picky listeners with its warm, evenly-balanced sound. We're trained to assume that good looks are a guise, but the H2's slick design complements the sound performance quite nicely. For your money, you can't do better than Grado's SR60e. The third-generation of the Brooklyn, NY-based company's Prestige Series is its best and most refined yet. The SR60e in particular is a smart choice if you're looking for an entry-level set of headphones that sounds like it should cost you way more than it does. Its open-backed ear cup design makes them a more breathable experience than what most on-ear headphones can deliver. Might be pricey for some Plantronics' BackBeat Sense is a home run on nearly all accounts. The design yields comfort and appeal. Its sound performance, battery life and features all deliver without a hitch. Usually, there are a few things that I'd like to see fixed in a set of headphones. In the case of the BackBeat Sense, I wish that the ear cups could fold into the headband to be ultra-portable. But for a set of headphones that gets so much right, I can't nitpick. These cans are worth every penny for someone looking to leap for a classy-looking set of wireless headphones. You, like everyone else, probably wants a set of headphones that nails the tricky blend of design, useful features and incredible sound. You might think that you need to flush your savings to enjoy such a pair of cans. Protip: you don't. The $99 Noontec Zoro II Wireless offer a warm and fun sound signature. With a 35-hour battery life and multipoint Bluetooth, these headphones offer an impressive value against more expensive competition. Klipsch has delivered on making a set of on-ear headphones that are perfect for music lovers looking for true, unbiased sound reproduction of their music. Not to mention that this is the most comfortable pair of on-ear headphones I've worn yet. While their design may not offer the most amount of flexibility, the awesome sound reproduction of the Klipsch Reference On-Ear make them one of the more versatile options for headphones and a fantastic value at that. The Solo 3 Wireless appear almost identical to the Solo 2 headphones from a quick glance. That being said, the majority of the changes Apple made to its class-leading cans come internally, baking its mobile phone know-how into these headphones to ramp-up their wireless skills and maximise battery life. In terms of wireless performance, these $299 (£249/AU$399.95) headphones are as reliable as any out there. However, you can get better sound quality at the price and, for just a little more, the Bose QuietComfort 35 offer much better comfort and active noise cancellation to make your work commute about 95 per cent more relaxing. The Bowers and Wilkins P5 Series 2 isn't the most feature-rich option, but in terms of sheer sound and build quality, they easily raise the bar for the competition to follow. These audiophile-grade headphones are a must-buy for anyone serious about hearing music the way it was intended. So long as you have the money, there's not much else in the on-ear market that can match this package at this price point. The Samsung Level On Pro Wireless are one of the few headphones I've tested that feel like they're meant as a package deal for another device. Yes they'll work with every Bluetooth and 3.5mm jack-equipped handset on the market, but you're better off sticking to a Samsung device in order to squeeze every ounce of aural goodness from the UHQ audio codec. It's one of the comfiest pair of cans on the market, and one of the best noise-cancelling, too. If it had a better sound quality for the vast majority of cell phone users it would be an easy recommendation but, as it stands, really makes the most sense at checkout when purchased alongside Samsung's Next Big Thing.


Kzhyshkowska J.,University of Heidelberg | Kzhyshkowska J.,Red Cross | Kzhyshkowska J.,Tomsk State University | Gudima A.,University of Heidelberg | And 6 more authors.
Journal of Leukocyte Biology | Year: 2015

Implants, transplants, and implantable biomedical devices are mainstream solutions for a wide variety of human pathologies. One of the persistent problems around nondegradable metallic and polymeric implants is failure of macrophages to resolve the inflammation and their tendency to stay in a state, named “frustrated phagocytosis.” During the initial phase, proinflammatory macrophages induce acute reactions to trauma and foreign materials, whereas tolerogenic anti-inflammatory macrophages control resolution of inflammation and induce the subsequent healing stage. However, implanted materials can induce a mixed pro/ anti-inflammatory phenotype, supporting chronic inflammatory reactions accompanied by microbial contamination and resulting in implant failure. Several materials based on natural polymers for improved interaction with host tissue or surfaces that release anti-inflammatory drugs/bioactive agents have been developed for implant coating to reduce implant rejection. However, no definitive, long-term solution to avoid adverse immune responses to the implanted materials is available to date. The prevention of implant-associated infections or chronic inflammation by manipulating the macrophage phenotype is a promising strategy to improve implant acceptance. The immunomodulatory properties of currently available implant coatings need to be improved to develop personalized therapeutic solutions. Human primary macrophages exposed to the implantable materials ex vivo can be used to predict the individual’s reactions and allow selection of an optimal coating composition. Our review describes current understanding of the mechanisms of macrophage interactions with implantable materials and outlines the prospects for use of human primary macrophages for diagnostic and therapeutic approaches to personalized implant therapy. © Society for Leukocyte Biology.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.3-2 | Award Amount: 7.47M | Year: 2013

IMMODGEL aims to identify adverse immune reactions to dental and larynx titanium implants and to develop a novel therapeutic strategy to significantly decrease the implant and medical device failure caused by these reactions via design of an innovative immunomodulatory system. The system will be designed to be fixed to an implant via an adhesive polyelectrolyte multilayer and control the immune response by autologous, phenotype modulated macrophages encapsulated in a hydrogel. The auxiliary nature of the design allows it to be adjusted to any implant, medical device or transplant. IMMODGEL will apply complex systems immunology, epidemiology, and functional approaches to identify key adverse immune reactions caused by implants and detrimental macrophage phenotypes around titanium implants. This will be used to establish the optimal biomaterial composition and cytokine delivery system for the immunomodulatory hydrogel design to revert macrophage-induced inflammatory reactions (M1) to the optimal tolerogenic and healing reactions (M2). Long-term fixation of the desired M2 phenotype will significantly decrease the level and duration of implant-induced inflammation, and optimise healing phase. The interaction of implants and medical devices with the immune system will be modelled to develop a Foreign Body Response on-a-chip to predict patients specific responses to implant materials and modify the immunomodulatory hydrogel accordingly, as a step towards personalized implants with minimal adverse reactions. The gels will be incorporated to engineered tissues for validation. Validation of the approach will be performed in vivo in animal models. Significantly suppressed inflammatory responses and optimal tissue remodelling and healing around titanium implants is expected. The key innovation will be the development of IMMODGEL as an auxiliary system to improve the outcomes of implantation and reduce the cost of implant complication and related medical costs in Europe.


Debry C.,Faculte Of Chirurgie Dentaireuniversite Of Strasbourg | Dupret-Bories A.,Hopitaux Universitaires Of Strasbourg | Vrana N.E.,Protip SAS | Hemar P.,Hopitaux Universitaires Of Strasbourg | And 2 more authors.
Head and Neck | Year: 2014

Background: Most patients perceive total laryngectomy as a mutilation carrying with it a loss of physical and psychological integrity. Thus, an artificial larynx system that can replace the laryngeal functions would significantly improve the quality of life for the afflicted patients. Methods: This report, with accompanying video, presents the first case in an ongoing clinical trial of laryngeal rehabilitation using an artificial larynx after total laryngectomy for squamous cell carcinoma, for an 8-month follow-up period. We depict the prosthesis' features, our 2-step surgical procedure, and the outcome. The prosthesis is formed of 2 parts: (1) a tracheal prosthesis with a porous titanium junction with trachea, which was implanted in the first step to ensure its colonization, and (2) a removable part composed of concentric valves that enable inhalation and exhalation. The second part was implanted endoscopically. The implant was monitored with a retrograde nasofibroscopy of the tracheal prosthesis lumen and CT scans over a course of 8 months. Results: The patient's functioning in the relevant postoperative problem areas, such as swallowing, breathing, and smelling, has significantly improved. The patient was able to talk in a whispering fashion while the tracheostomy was temporarily closed. The implant's porous part was in the process of being colonized by the surrounding tissue and no fistulas were observed as evidenced by barium swallow. Conclusion: As the current case shows, tracheotomy closure can be performed, and laryngeal functions are restored, by means of an implant. With further improvements, this system can alleviate the need for a permanent tracheostomy after total laryngectomy, while maintaining important larynx functions intact. © 2014 Wiley Periodicals, Inc.


Patent
Protip SAS | Date: 2012-11-20

The invention relates to a medical device for supporting an implant or prosthesis, formed by two parts including one part forming an upper ring (1) which is made from a rigid or semi-rigid solid biocompatible material and another part forming a lower ring (2) which is made from a rigid or semi-rigid, integrable or porous biocompatible material, said device being intended to receive an implant or a removable prosthesis at the upper ring and to be installed in situ by means of the lower ring.


Patent
Protip SAS | Date: 2012-09-06

The present invention relates to the field of prosthetics having the function of restoring swallowing, breathing and phonation to a patient having a dysfunctional larynx. More specifically, the present invention concerns a valve device forming an intra-laryngeal endoprosthesis intended for implanting in the anatomical larynx in place having the function of enabling breathing while forming a seal against elements such as saliva, mucus or any other element coming from the bolus. The complete intra-laryngeal endoprosthesis, as well as its various applications, are also the subject matter of the present invention.


Patent
Protip Sas | Date: 2012-05-09

The present invention relates to a hybrid implant for the support and/or the replacement of tissue, a method for its preparation and its use. According to the invention, the hybrid implant is made of a polymeric scaffold combined with a mechanically stable template. It is particularly suitable for the disorders and pathologies where the support and/or the replacement of a tissue is necessary. The hybrid implant is particularly designed for cell colonization at a particular part of the implant or the whole implant, in order to restore the tissue functioning.

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