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Frederick, MD, United States

Ying T.,Protein Interactions Group | Chen W.,Protein Interactions Group | Feng Y.,Protein Interactions Group | Wang Y.,Protein Interactions Group | And 3 more authors.
Journal of Biological Chemistry

Background: The CH3 domain of an antibody is a homodimer. Results: Soluble monomeric IgG1 CH3 (mCH3) exhibits pH-dependent binding to FcRn. Conclusion: The mCH3 can be used as a new scaffold for generation of binders with potentially enhanced half-life. Significance: The mCH3 is a promising fusion partner for therapeutic proteins with increased therapeutic efficacy. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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