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MARLBORO, MA, United States

Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 99.79K | Year: 2004

DESCRIPTION (provided by applicant): The goal of this effort is the creation of a new line of microcoil-based NMR detection probes specifically targeted to protein analysis. The submitting organization will utilize a patented and exclusively licensed


Protasis Corporation | Entity website

About Protasis Corp. is the leader in flow NMR ...


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 99.57K | Year: 2010

DESCRIPTION (provided by applicant): The impact over the past five years of the development of microliter-volume, highly mass-sensitive NMR detection probes has been substantial. Combining sensitivity, simplicity, and economy, these room-temperature probes require very minor initial shimming and virtually no shimming or tuning adjustments between individual samples, and do not carry the high cost or maintenance requirements of cryogenically-cooled probe technologies while providing comparable mass sensitivity. As such, they are ideally suited to the analysis of low-abundance analytes typical of liquid chromatography fractions. The proposed effort now offers to extend this product capability to include 19F detection, a technique that is of great importance to university research and to pharmaceutical and other chemical product industries due to the inherent chemical dispersion that 19F offers in terms of chemical shift and due to its natural absence in biological samples. This proposal specifically seeks funding to develop a new category of probe that can accomplish both 1H and 19F detection (using a single probe) to obtain background-free, quality data. A favored approach of this proposal utilizes a unique dual flowcell architecture owned by Protasis to essentially incorporate two separately-optimized probe functionalities into a single mechanical probe package. The potential impact on human health resulting from new generations of economical and practical NMR-based analyzers is extremely high. PUBLIC HEALTH RELEVANCE: This proposal seeks funding to develop a new category of mass-sensitive probe that can accomplish both 1H and 19F detection (using a single probe) to obtain background-free, quality data from low-abundance analytes, e.g. fractions originating from liquid chromatography. Research groups asking for this new generation of high performance NMR detection technology include the pharmaceutical industry, who require an economically-justifiable means to include 19F detection in discovery and development efforts using smaller amounts of sample than was available in the past, and academic researchers who in addition to economy also wish to realize the performance advantages of working at smaller size scale. The potential impact on human health resulting from new generations of economical and practical NMR-based analyzers is extremely high.


Protasis Corporation | Entity website


Patent
Protasis Corporation | Date: 2010-11-12

A fluid separation conduit cartridge comprising a fluid separation conduit is disclosed. In certain embodiments the fluid separation conduit is potted to provide operation at increased pressures. In other embodiments, the fluid separation conduit cartridge has one or more memory units. The memory units are operative to store data such as, for example, cartridge usage and test results.

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