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San Francisco, CA, United States

Patent
Prosetta | Date: 2015-04-02

The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.


Novel methods and compounds for treating Alzheimers Disease are provided. In one aspect, the invention provides methods for treating Alzheimers Disease by administering certain phenothiazine derivatives. In one embodiment, the methods include administering an effective amount of a 3-oxo-7-dialkyl-amino-phenothiazine derivative, or 3-oxo-7-dialkyl-amino-phenothiazine. In another embodiment, the invention provides methods for treating Alzheimers Disease by administering an effective amount of a 3,7-diazetidin-1-yl-phenothiazine or a derivative thereof. In another aspect, the invention provides novel azetidinyl phenothiazine compounds.


The invention provides a cell-free system comprising not more than about 5% wheat germ extract for expressing proteins such as viral proteins and proteins required for viral capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids, are provided. Further provided are methods for expressing proteins such as viral proteins, proteins required for capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids using a cell-free system comprising not more than about 5% wheat germ extract. Further provided are methods to assay for compounds that modulate viral protein, viral capsid assembly, and assembly of proteins into multiprotein complexes whose disruption can ameliorate bacterial, parasitic, metabolic, oncologic, immunologic, or CNS disease in a cell-free system comprising not more than about 5% wheat germ extract.


Patent
Prosetta | Date: 2013-07-24

The present invention provides compositions and methods of use in investigations of the formation of multiprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.


Patent
Prosetta | Date: 2010-02-03

Methods, apparatus, and software for identifying sets of genomic oligonucleotides that identify a viral family and for determining sets of probes and primers that can be used to identify members of viral families in a sample are provided. In one embodiment, the method of the present invention includes normalizing viral genomic oligonucleotide sequence data from at least one viral family, and identifying at least one oligonucleotide sequence that is unique to each viral family. An array of the identified oligonucleotide sequences is made. Primers provided by the present invention are used to amplify viral family genomic sequences in a biological sample of interest, and probes provided using the present invention, e.g., attached to an array or biochip, are then used to detect the presence of the corresponding virus(es) present in the sample by hybridization.

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