Ng Y.,Indiana University |
Lacy J.L.,Proportional Technologies, Inc. |
Fletcher J.W.,Indiana University |
Green M.A.,Indiana University
Applied Radiation and Isotopes | Year: 2014
The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23GBq 62Zn at 9:00AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672±172MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [62Cu]Cu-ETS for PET perfusion imaging. © 2014 Elsevier Ltd.
Proportional Technologies, Inc. | Date: 2013-10-10
The present invention includes an apparatus and method for neutron radiation detection. The apparatus comprises combining thin walled, boron-coated straw tubes with a plastic moderator material interspersed around the tubes. The method involves using such an apparatus through application of voltage to a central wire running inside the tubes and collecting electrical pulses generated thereby.
Proportional Technologies, Inc. | Date: 2015-11-12
A method is disclosed of measuring the thickness of a thin coating on a substrate comprising dissolving the coating and substrate in a reagent and using the post-dissolution concentration of the coating in the reagent to calculate an effective thickness of the coating. The preferred method includes measuring non-conducting films on flexible and rough substrates, but other kinds of thin films can be measure by matching a reliable film-substrate dissolution technique. One preferred method includes determining the thickness of Boron Carbide films deposited on copper foil. The preferred method uses a standard technique known as inductively coupled plasma optical emission spectroscopy (ICPOES) to measure boron concentration in a liquid sample prepared by dissolving boron carbide films and the Copper substrates, preferably using a chemical etch known as ceric ammonium nitrate (CAN). Measured boron concentration values can then be calculated.
Proportional Technologies, Inc. | Date: 2013-10-22
An apparatus and a process is disclosed for applying a boron coating to a thin foil. Preferably, the process is a continuous, in-line process for applying a coating to a thin foil comprising wrapping the foil around a rotating and translating mandrel, cleaning the foil with glow discharge in an etching chamber as the mandrel with the foil moves through the chamber, sputtering the foil with boron carbide in a sputtering chamber as the mandrel moves through the sputtering chamber, and unwinding the foil off the mandrel after it has been coated. The apparatus for applying a coating to a thin foil comprises an elongated mandrel. Foil preferably passes from a reel to the mandrel by passing through a seal near the initial portion of an etching chamber. The mandrel has a translation drive system for moving the mandrel forward and a rotational drive system for rotating mandrel as it moves forward. The etching chamber utilizes glow discharge on a surface of the foil as the mandrel moves through said etching chamber. A sputtering chamber, downstream of the etching chamber, applies a thin layer comprising boron onto the surface of the foil as said mandrel moves through said sputtering chamber. Preferably, the coated foil passes from the mandrel to a second reel by passing through a seal near the terminal portion of the sputtering chamber.
Proportional Technologies, Inc. | Date: 2013-10-22
An apparatus and a process are disclosed for straw tube formation utilized in manufacturing boron coated straw neutron detectors. A preferred embodiment of the process for creating a thin walled straw for use in a boron-coated straw neutron detector comprises providing foil having a boron coating on a surface, forming the coated foil into a cylindrical tube having a longitudinal seam and the boron coated surface on the inside of the cylindrical tube, and then ultrasonically welding closed the seam of the tube. Optionally, the cylindrical tube can then be drawn through a die to form a straw tube having a non-circular cross section, preferably a star-shaped cross section.
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 218.63K | Year: 2016
Project Summary This Phase research project will develop a somatostatin receptor targeted Cu radiopharmaceutical for clinical imaging of neuroendocrine tumors with positron emission tomography PET The short lived Cu radiolabel is readily and repeatedly available for on demand radiopharmaceutical labeling via a compact modular Zn Cu radionuclide generator system developed by Proportional Technologies Inc Somatostatin receptors are found to be highly expressed by most neuroendocrine tumors and are a well established molecular target for PET detection of these malignancies with a family of Ga labeled receptor targeted peptides that have come into widespread clinical use outside the USA This project will develop an alternative approach to PET imaging of neuroendocrine tumors employing Cu DOTA TATE as a radiopharmaceutical that can readily be employed for assessment of tumor burden while still allowing immediate independent F FDG PET assessment of tumor aggressiveness thus more fully characterizing the individualandapos s disease state Cu DOTA TATE will also be attractive for neuroendocrine tumor imaging in pediatrics due to relatively low patient radiation exposure when imaging with such a short lived nuclide Our commercialization approach will be to seek FDA approval for the combination of our Cu generator and a companion sterile kit that allows on demand technologist compounding of the Cu DOTA TATE radiopharmaceutical immediately prior to injection For this Phase project our Specific Aims are to produce and validate a lyophilized kit formulation for on demand clinical site compounding of Cu DOTA TATE and to evaluate Cu DOTA TATE distribution pharmacokinetics and dosimetry in humans Additionally the feasibility of whole body Cu DOTA TATE tumor imaging will be documented by direct comparison of Cu findings to contemporaneous clinical exams obtained with In OctreoScan SPECT or Ga DOTA NOC PET These Phase experiments are expected to demonstrate that Cu DOTA TATE can be reliably and robustly compounded at high radiochemical purity and that whole body Cu DOTA TATE PET appears suitable for clinical neuroendocrine tumor imaging thereby establishing the foundation for Phase studies to assess the efficacy of Cu DOTA TATE PET CT in patient management Statement of Relevance This project will advance public health by development of an imaging technology that improves detection of neuroendocrine tumors as well as physicianandapos s ability to plan appropriate treatment of patients with neuroendocrine cancer The proposed tumor targeted copper radiopharmaceutical can be commercially distributed to any clinical PET imaging facility in the United States relying on a longer lived zinc copper parent daughter radionuclide generator system already developed by Proportional Technologies Inc thereby providing universal patient access to receptor based PET neuroendocrine tumor imaging
Agency: Department of Defense | Branch: Defense Threat Reduction Agency | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2014
ABSTRACT: Boron coated straw detectors developed by Proportional Technologies, Inc have proven to perform exceptionally well in many neutron detection applications of interest to DOD. Over the last several years PTI has delivered many systems to government branches BENEFITS: The project will develop a cost effective neutron detector capable of determining both direction and energy content of a neutron source at distance. Although directional neutron detection is recognized as highly beneficial in search scenarios no effectiv
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 1000.00K | Year: 2013
Neutron scattering is a powerful technique that is critically important for materials science and structural biology applications. Pressurized 3He tubes are widely used in this field. However, the severe 3He shortage prevents this medium from satisfying even current installation upgrades. Clearly other detection media and instrumentation techniques must be found to come close to taking full advantage of powerful, expensive facilities like the Spallation Neutron Source in the US. A neutron detection technology, based on boron-coated straw (BCS) detectors, has been proposed to replace 3He tubes in large-scale neutron science instruments. In previous projects funded by the US government, BCS-based imaging panels were developed and tested successfully at a national neutron scattering facility. The current project aims to develop production methods, including a critical in-house 10B4C high volume sputter coating system and automated in line detector tube production system, that together will dramatically increase production capacity to the level required, and as well offer a significant cost reduction. The capability to efficiently and effectively produce BCS detectors in high volumes to meet the communitys needs for large inelastic instruments will be demonstrated with a full scale prototype imaging panel. The panel will be comprehensively tested and evaluated at a US neutron science facility.
Proportional Technologies, Inc. | Date: 2015-11-12
A method and apparatus is disclosed for improved magnetron sputtering utilizing a movable magnet. Preferably, the apparatus can be used to move the magnet along any two dimensional paths within the range of the moving stages. In one preferred method for sputtering a coating using a magnetron sputtering apparatus comprises the step of moving a magnet assembly in two dimensions during the sputtering process to allow increased erosion area of the target as compared to stationary magnets. In another preferred embodiment the invention includes a magnetron sputtering apparatus comprising a first motion stage allowing movement in a first direction, a second motion stage allowing movement in second direction, a magnet assembly operably attached to said first and second motion stages, and a control unit, wherein said first motion stage moves in a general first direction and second motion stage moves in a generally second direction which is generally orthogonal and wherein said control unit controls the movement of the motion stages.
Agency: Department of Energy | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 987.85K | Year: 2014
Neutron detectors for well logging require stable operation in an extreme environment of high temperatures, (175°C up to 260°C), high mechanical vibration, and shock. Helium-3 tubes have been the preferred solution, as they satisfy these requirements to 175°C, can be configured in small packages, are easy to fabricate, have low power requirements, and offer high detection efficiency. The supply of 3He gas has dwindled in recent years, however, and this medium can no longer support the demand in well- logging and other fields. Proportional Technologies Inc. (PTI) has developed boron-coated straw (BCS) detectors that have been shown to successfully replace 3He tubes in homeland security and neutron science applications. PTI has also developed a detector designed to withstand extreme temperatures. With recent developments PTI's straws are ultrasonically welded into all metal tubes and formed into corrugated structures that enhance the straw wall area by as much as two fold. The new construction is virtually impervious to temperature extremes. The basic Boron coated foil can be taken to 1000°C and -200°C repeatedly with no effect on the integrity of the coating nor foil structure. The corrugated structures lock together and substantially stabilize the straw walls against extreme vibration and shock. For this project, we propose a Fast Track development of a commercially attractive BCS-based neutron detector for well logging. The detector will share many of the attractions of 3He tubes, including compact size, high efficiency, low power consumption, and reliable operation in extreme environments. (of at least 250°C). This will take the straw detector well beyond the temperature and robustness capabilities of 3He detectors and open new horizons in well logging. Commercial Applications and Other Benefits: Neutron detection is of substantial importance to US and world economy by aiding in discovery of new oil and gas fields. As newer oil field exploration is moving into depths where temperatures easily reach 250°C, we expect the proposed straw neutron detector will provide a substantial increase in operational temperature and also to provide unexcelled reliability reducing the high cost of oil and gas exploration. As such, this development is very important to US economy moving forward.