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Goteborg, Sweden

Svendsen I.E.,Malmo University | Santos O.,Malmo University | Sotres J.,Malmo University | Wennerberg A.,Malmo University | And 3 more authors.
Biofouling | Year: 2012

Ellipsometry and mechanically assisted sodium dodecyl sulphate elution was utilized to study the adsorption of human serum albumin (HSA), human immunoglobulin G (IgG), and laminin-1, as well as competitive adsorption from a mixture of these proteins on spin-coated and sintered hydroxyapatite (HA) surfaces, respectively. The HA surfaces were characterized with respect to wettability and roughness by means of water contact angles and atomic force microscopy, respectively. Both surface types were hydrophilic, and the average roughness (Sa) and surface enlargement (Sdr) were lower for the sintered compared to the spin-coated HA surfaces. The adsorbed amounts on the sintered HA increased as follows: HSA < laminin-1 < IgG < the protein mixture. For the competitive adsorption experiments, the adsorbed fractions increased accordingly: HSA < laminin-1 < IgG on both types of HA substratum. However, a higher relative amount of HSA and laminin-1 and a lower relative amount of IgG was found on the spin-coated surfaces compared to the sintered surfaces. The effects observed could be ascribed to differences in surface roughness and chemical composition between the two types of HA substratum, and could have an influence on selection of future implant surface coatings. © 2012 Copyright Taylor and Francis Group, LLC. Source


Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m


Patent
Promimic | Date: 2015-06-12

Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.


Patent
Promimic | Date: 2013-07-08

Composites and methods of producing a mouldable bone substitute are described, A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.


Trademark
Promimic | Date: 2016-03-21

Chemicals used in industry in the form of coatings of biocompatible materials being components of implants, in particular of surgical, medical, orthopaedic and traumatological implants, dental implants and implants for mechanical stabilisation and fixing; Chemicals for use in industry and science; Chemical compositions being coatings for medical or pharmaceutical implants. Pharmaceutical implants; Biological implants; Pharmaceutical and veterinary preparations; Implants comprising living tissue; Surface coatings for pharmaceutical and biological implants. Artificial organs, prostheses and implants; Medical implants; Biodegradable implants; Surgical, medical, dental and veterinary apparatus and instruments; Surface coatings for artificial organs, prostheses and implants; Surface coatings for medical implants; Dental implants.

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