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Gorrell R.J.,Infection and Immunity Program | Gorrell R.J.,Monash Biomedicine Discovery Institute | Zwickel N.,Infection and Immunity Program | Zwickel N.,Monash Biomedicine Discovery Institute | And 6 more authors.
Journal of Infectious Diseases | Year: 2016

Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Tomas A.,Infection and Immunity Program | Tomas A.,Institute Investigacion Sanitaria Of Palma Idispa | Tomas A.,Research Center Biomedica en Red Enfermedades Respiratorias | Lery L.,Institute Pasteur Paris | And 28 more authors.
Journal of Biological Chemistry | Year: 2015

Background: There is limited knowledge of Klebsiella pneumoniae determinants implicated in the blocking of the NF-κB signaling pathway. Results:Ahigh-throughput genetic screen led to the identification of 114 putative K. pneumoniae genes that are associated with suppression of NF-κB activation. Conclusion: CPS, LPS, and the T2SS-secreted PulA are needed for immune evasion. Significance: A new therapeutic approach to treat Klebsiella infections will be the prevention of immune evasion. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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