Cambridge, MA, United States
Cambridge, MA, United States

Time filter

Source Type

Patent
Prognosys | Date: 2016-11-11

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.


Patent
Prognosys | Date: 2016-11-11

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.


Patent
Prognosys | Date: 2016-11-11

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.


Patent
Prognosys | Date: 2016-12-07

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.


Patent
Prognosys | Date: 2017-04-05

The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.


Patent
Prognosys | Date: 2016-07-29

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.


Patent
Prognosys | Date: 2016-06-20

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 225.00K | Year: 2014

DESCRIPTION (provided by applicant): New technologies are needed to enable the molecular characterization of the complex relationship between the immune system and cancer. This proposal aims to apply a novel approach to high-dimensional analysis of cancersamples, in order to determine if it can help to elucidate the interactions between the immune system and cancers, and ultimately to correlate these effects with outcome. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The interaction of theimmune system and cancer is important to outcome but is poorly understood. We are developing a more powerful way to analyze this complex interaction. If successful, this project may enable improvements in the molecular analysis and treatment of cancer.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 1.83M | Year: 2013

DESCRIPTION provided by applicant There is a need for new technologies to enable multiplexed analysis of collections of biomarkers in biological samples We propose to develop a novel assay format for detecting and analyzing many biomarkers simultaneously In order to do this we will develop reagents and methods and validate the approach using a model system If successful our long term goal is to increase the level of multiplexing to enable analysis on a scale that is not feasible with current methods PUBLIC HEALTH RELEVANCE The technology we are developing is designed for detecting and analyzing large sets of biomarkers This will be useful for detecting patterns of expression that provide information on normal and disease states It has application in basic research and may also be useful in the diagnosis treatment and prevention of disease


Patent
Prognosys | Date: 2015-05-27

The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.

Loading Prognosys collaborators
Loading Prognosys collaborators