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Budu V.,Prof. Dr. Dorin Hociota Institute for Phono Audiology and Functional ENT Surgery | Bulescu I.,Prof. Dr. Dorin Hociota Institute for Phono Audiology and Functional ENT Surgery | Aurelia Mogoanta C.,University of Medicine and Pharmacy of Craiova
Romanian Journal of Morphology and Embryology | Year: 2013

Juvenile nasopharyngeal angiofibromas (JNA) are rare, benign, highly vascular tumors which appear in proximity to the sphenopalatine foramen. The tumor arises most commonly in adolescent males suggesting that in could be hormonally responsive. Although it is histologically benign, it has a high destructive potential and a high grade of recurrence. It is a fibrous vascular tumor with vascular sources from branches of the external or internal carotid arteries. Modern treatment of JNA includes surgery and also radiotherapy, chemotherapy and hormone therapy. This paper presents two cases from the eight of our clinic's experience, with morphological features which made their treatment challenging. Source


Anghel A.-E.,POSDRU 159 1.5 S 135760 CERO | Anghel A.-E.,Medical Center | Ene C.-D.,Carol Davila University of Medicine and Pharmacy | Nicolae I.,Dr. Victor Babes Clinical Hospitals | And 4 more authors.
Romanian Biotechnological Letters | Year: 2015

Cutaneous melanoma remains a major health problem, having a world-wide increased incidence, still lacking an efficient therapy for the advanced stages. Intense research is seeking to establish new immune-related therapeutic approaches and to unveil new biomarkers that can orient these therapies. Complex mechanisms of intracellular signaling guide tumorigenesis, while inter-cellular communications sustained by circulating molecules promote advanced processes like progression and metastasis. Among the chorus of immune-related molecules, interleukin 8 has its voice heard especially in processes like angiogenesis, hypoxia, and this array of events leading to the advanced metastasis. Renal metastasis of melanoma accounts for an important percentage of late stage melanoma patients and new biomarkers can pinpoint the appearance of this metastasis. © 2015 University of Bucharest. Source


Budu V.,Carol Davila University of Medicine and Pharmacy | Mogoanta C.A.,University of Medicine and Pharmacy of Craiova | Fanuta B.,ENT Surgery Clinic | Bulescu I.,Prof. Dr. Dorin Hociota Institute for Phono Audiology and Functional ENT Surgery
Romanian Journal of Morphology and Embryology | Year: 2013

Alongside the past development of endoscopic sinus surgery, knowledge about the anatomy of the sinuses has become crucial for surgeons. The sphenoid sinus is one of the most variable of all sinuses. Its relations to vital vascular and nervous elements make its approach a challenge for endoscopic surgeons. These relations include the internal carotid artery, the optic nerve, the pituitary gland, the Vidian nerve, and other vascular and nervous elements depending on the size of the sinus. This paper will make a review of these anatomical relations and their importance in endoscopic sphenoid surgery. Source

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