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Anghel A.-E.,POSDRU 159 1.5 S 135760 CERO | Anghel A.-E.,Medical Center | Ene C.-D.,Carol Davila University of Medicine and Pharmacy | Nicolae I.,Dr Victor Babes Clinical Hospitals | And 4 more authors.
Romanian Biotechnological Letters | Year: 2015

Cutaneous melanoma remains a major health problem, having a world-wide increased incidence, still lacking an efficient therapy for the advanced stages. Intense research is seeking to establish new immune-related therapeutic approaches and to unveil new biomarkers that can orient these therapies. Complex mechanisms of intracellular signaling guide tumorigenesis, while inter-cellular communications sustained by circulating molecules promote advanced processes like progression and metastasis. Among the chorus of immune-related molecules, interleukin 8 has its voice heard especially in processes like angiogenesis, hypoxia, and this array of events leading to the advanced metastasis. Renal metastasis of melanoma accounts for an important percentage of late stage melanoma patients and new biomarkers can pinpoint the appearance of this metastasis. © 2015 University of Bucharest.


Budu V.,Carol Davila University of Medicine and Pharmacy | Mogoanta C.A.,University of Medicine and Pharmacy of Craiova | Fanuta B.,Emergency County Hospital | Bulescu I.,Prof Dr Dorin Hociota Institute For Phono Audiology And Functional Ent Surgery
Romanian Journal of Morphology and Embryology | Year: 2013

Alongside the past development of endoscopic sinus surgery, knowledge about the anatomy of the sinuses has become crucial for surgeons. The sphenoid sinus is one of the most variable of all sinuses. Its relations to vital vascular and nervous elements make its approach a challenge for endoscopic surgeons. These relations include the internal carotid artery, the optic nerve, the pituitary gland, the Vidian nerve, and other vascular and nervous elements depending on the size of the sinus. This paper will make a review of these anatomical relations and their importance in endoscopic sphenoid surgery.


Budu V.,Prof Dr Dorin Hociota Institute For Phono Audiology And Functional Ent Surgery | Bulescu I.,Prof Dr Dorin Hociota Institute For Phono Audiology And Functional Ent Surgery | Aurelia Mogoanta C.,University of Medicine and Pharmacy of Craiova
Romanian Journal of Morphology and Embryology | Year: 2013

Juvenile nasopharyngeal angiofibromas (JNA) are rare, benign, highly vascular tumors which appear in proximity to the sphenopalatine foramen. The tumor arises most commonly in adolescent males suggesting that in could be hormonally responsive. Although it is histologically benign, it has a high destructive potential and a high grade of recurrence. It is a fibrous vascular tumor with vascular sources from branches of the external or internal carotid arteries. Modern treatment of JNA includes surgery and also radiotherapy, chemotherapy and hormone therapy. This paper presents two cases from the eight of our clinic's experience, with morphological features which made their treatment challenging.


Budu V.A.,Prof Dr Dorin Hociota Institute For Phono Audiology And Functional Ent Surgery | Bulescu I.A.,University of Bucharest | Popp C.G.,Colentina Clinical Hospital | Mocanu B.C.,Prof Dr Dorin Hociota Institute For Phono Audiology And Functional Ent Surgery | Mogoanta C.A.,University of Medicine and Pharmacy of Craiova
Romanian Journal of Morphology and Embryology | Year: 2015

Tumors of the parapharyngeal space are rare accounting approximately for 0.5% of all head and neck tumors. In the retrostyloid space, schwannomas are a more common finding, in contrast to other tumors. Usually, they present with a variety of slight symptoms until they grow in size and compress surrounding organs. Surgical treatment of parapharyngeal space tumors is difficult; due to the anatomical complex area, they develop in, and include several approaches, according to its size and relations. In this paper, we present a case of a 63-year-old female with a vagus nerve schwannoma in the parapharyngeal space. Beside the surgical difficulties, the resected tumor had a peculiar histopathological aspect (large areas of degeneration and atypia and little typical palisading) that compelled a thorough histological and immunohistochemical evaluation for positive and differential diagnosis. © 2015, Rom J Morphol Embryol. All rights reserved.


Roceanu A.,University of Bucharest | Muresanu D.F.,University of Medicine and Pharmacy, Cluj-Napoca | Popescu B.O.,Carol Davila University of Medicine and Pharmacy | Popescu B.O.,Colentina Clinical Hospital | And 8 more authors.
Romanian Journal of Neurology/ Revista Romana de Neurologie | Year: 2014

Vertigo and dizziness are among the most frequent presenting symptoms, not only in neurology, but also in ENT and internal medicine clinics.Vertigo is a spinning sensation or the feeling that the surroundings are spinning.Floating sensation, lightheadiness, forward, backward – and sideward fall sensation, walking instability, gait hesitation or unsteadiness are other type of dizziness.Several clinical pictures of different etiologies include vertigo and dizziness as underlying complaint. Diagnosis should be based on clinical history and neurotological evaluation.A common perspective of neurologists, ENT doctors and general medicine physicians is needed for a better diagnosis and treatment of vertigo and dizziness patients. © 2014 Editura Medicala AMALTEA. All rights reserved.


PubMed | Prof Dr Dorin Hociota Institute For Phono Audiology And Functional Ent Surgery
Type: Case Reports | Journal: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie | Year: 2013

Juvenile nasopharyngeal angiofibromas (JNA) are rare, benign, highly vascular tumors which appear in proximity to the sphenopalatine foramen. The tumor arises most commonly in adolescent males suggesting that in could be hormonally responsive. Although it is histologically benign, it has a high destructive potential and a high grade of recurrence. It is a fibrous vascular tumor with vascular sources from branches of the external or internal carotid arteries. Modern treatment of JNA includes surgery and also radiotherapy, chemotherapy and hormone therapy. This paper presents two cases from the eight of our clinics experience, with morphological features which made their treatment challenging.

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