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Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.2-01 | Award Amount: 7.65M | Year: 2012

The main objective of the BACCHUS project is to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans. To achieve this, the BACCHUS consortium has assembled 12 leading Research & Technological centres and 16 SMEs (with ca 30% of the EC requested contribution allocated to the SMEs). BACCHUS thus contains SMEs directly involved in developing food products and pursuing health claims, experts in health claims legislation and the EFSA review process, and academic and industry partners who provide high quality food and health research that can underpin health claims. Existing SME-developed products that have clear potential for obtaining favourable opinions for health claims have been selected as test cases for study. These have been aligned with a series of work-packages each of which addresses key aspects of the EFSA health claim evaluation process (legislation and dossiers; product/bioactive characterisation; habitual intakes; bioavailability; mechanisms and biomarkers; clinical trials evidence of health benefit) that will deliver tools, processes and high quality original science. Scientific results and best practice guidelines will be made publically available and thus support future claims for industry. The scope and completeness of the existing bioactive database (eBASIS) that includes both compositional and biological effects data will be extended and developed as a sustainable tool with various training materials. All outcomes will be disseminated broadly by direct engagement with SMEs via an existing European SME association, with stakeholders via seminars, newsletters and press releases, as well as through traditional scientific routes (high quality publications, and conference presentations).


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.77M | Year: 2014

The BIopolymer BAsed FOOd Delivery Systems (BIBAFOODS) network will train young researchers for the advancement of food science and technology, by providing them with the complementary skills necessary to develop the future sustainable food industry and entrepreneurial skills crucial for creating biotechnological food oriented start-up companies. This collaborative training network will combine the complementary training capabilities of each individual partner institution to improve the trainees chances for employment and promote health and welfare in the EC by providing the capability to develop novel functional foods. The scientific focus of the research training is on colloidal delivery systems to protect and deliver active components via foods, resulting in novel functional foods. The development of these systems is to be based on only food-grade ingredients and upon economical feasible processes. The hypothesis is that the materials and coatings can be made responsive to the external chemical conditions and therefore suitable for controlled releases targeted at a desired stage during food processing or at a specific point during digestion of the food, e.g. in the intestinal tract. This will involve probiotic bacteria and enzymes that are liberated and allowed to be active in a controllable way. The ultimate successful materials ensure stability of the active component during long term storage prior to food production, during food production or during digestion, but at the same time liberating the active component at the right point. The behaviour and interaction of the delivery systems will be studied by simulation of gastric and intestinal conditions and by implementation in food production and formulation into probiotic products. To summarize, through the training in BIBAFOODS, 14 young researchers will achieve superior qualifications that will make them highly competitive and attractive for the European food and bio-tech industry.


Marzorati M.,Ghent University | Vanhoecke B.,Ghent University | De Ryck T.,Ghent University | Sadaghian Sadabad M.,University of Groningen | And 10 more authors.
BMC Microbiology | Year: 2014

Background: Recent scientific developments have shed more light on the importance of the host-microbe interaction, particularly in the gut. However, the mechanistic study of the host-microbe interplay is complicated by the intrinsic limitations in reaching the different areas of the gastrointestinal tract (GIT) in vivo. In this paper, we present the technical validation of a new device - the Host-Microbiota Interaction (HMI) module - and the evidence that it can be used in combination with a gut dynamic simulator to evaluate the effect of a specific treatment at the level of the luminal microbial community and of the host surface colonization and signaling. Results: The HMI module recreates conditions that are physiologically relevant for the GIT: i) a mucosal area to which bacteria can adhere under relevant shear stress (3 dynes cm -2); ii) the bilateral transport of low molecular weight metabolites (4 to 150 kDa) with permeation coefficients ranging from 2.4 × 10 -6 to 7.1 × 10-9 cm sec-1; and iii) microaerophilic conditions at the bottom of the growing biofilm (PmO2 = 2.5 × 10-4 cm sec-1). In a long-term study, the host's cells in the HMI module were still viable after a 48-hour exposure to a complex microbial community. The dominant mucus-associated microbiota differed from the luminal one and its composition was influenced by the treatment with a dried product derived from yeast fermentation. The latter - with known anti-inflammatory properties - induced a decrease of pro-inflammatory IL-8 production between 24 and 48 h. Conclusions: The study of the in vivo functionality of adhering bacterial communities in the human GIT and of the localized effect on the host is frequently hindered by the complexity of reaching particular areas of the GIT. The HMI module offers the possibility of co-culturing a gut representative microbial community with enterocyte-like cells up to 48 h and may therefore contribute to the mechanistic understanding of host-microbiome interactions. © 2014 Marzorati et al.; licensee BioMed Central Ltd. Source


Marzorati M.,Ghent University | Maignien L.,Ghent University | Verhelst A.,ProDigest | Luta G.,Mannatech Inc | And 5 more authors.
Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology | Year: 2013

The combination of a Simulator of the Human Intestinal Microbial Ecosystem with ad hoc molecular techniques (i.e. pyrosequencing, denaturing gradient gel electrophoresis and quantitative PCR) allowed an evaluation of the extent to which two plant polysaccharide supplements could modify a complex gut microbial community. The presence of Aloe vera gel powder and algae extract in product B as compared to the standard blend (product A) improved its fermentation along the entire simulated colon. The potential extended effect of product B in the simulated distal colon, as compared to product A, was confirmed by: (i) the separate clustering of the samples before and after the treatment in the phylogenetic-based dendrogram and OTU-based PCoA plot only for product B; (ii) a higher richness estimator (+33 vs. -36 % of product A); and (iii) a higher dynamic parameter (21 vs. 13 %). These data show that the combination of well designed in vitro simulators with barcoded pyrosequencing is a powerful tool for characterizing changes occurring in the gut microbiota following a treatment. However, for the quantification of low-abundance species - of interest because of their relationship to potential positive health effects (i.e. bifidobacteria or lactobacilli) - conventional molecular ecological approaches, such as PCR-DGGE and qPCR, still remain a very useful complementary tool. © 2012 Springer Science+Business Media Dordrecht. Source


Possemiers S.,Ghent University | Duysburgh C.,ProDigest | Halford J.C.G.,University of Liverpool | Marzorati M.,Ghent University
Food Science and Technology (London) | Year: 2013

Some experts describe the aims of SATIN, a five-year, multidisciplinary EU-funded project that will examine the mechanisms underpinning appetite expression. The SATIN or SATiety INnovation project is designed to develop functional food products for weight management. A multidisciplinary consortium has been assembled to achieve this objective. Eighteen academic and industrial partners from nine European Member States, coordinated by the University of Liverpool, have started to work jointly to successfully reach the final aim of the project. The aim is to generate safe and effective food products for the regulation of food intake by accelerating within-meal satiation, strengthening post-meal satiety, and suppressing appetite through the latest processing methods. A number of intermediate objectives have been generated as the results of seven interconnected work packages [WP] to achieve this objective. Source

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