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Farage M.A.,Procter and Gamble | Miller K.W.,Procter and Gamble | Azuka C.E.,Procter and Gamble | Wang B.,Procter and Gamble | And 6 more authors.
Reviews on Recent Clinical Trials | Year: 2013

Manufacturers of consumer products consistently seek to improve marketed products in terms of both safety and efficacy. The desire for continued improvement is seen even in well-established products such as catamenial products which have existed in some form for thousands of years. A recent innovation in the design of menstrual pads is the addition of a surface finish of emollient for the purpose of increasing comfort during wear. The present paper presents different evaluations of such an emollient-treated menstrual pad with a novel absorbent core. These investigations demonstrated product tolerability, defined the optimal formulation and concentration of the emollient-containing finish, and demonstrated successful transfer of the emollient to the relevant skin surface. In addition, enhancement of skin moisturization, associated with exposure to the emollient-treated pad, was demonstrated by several technologies: assessment of skin moisturization by Corneometer®, skin friction testing, and skin capacitance. © 2012 Bentham Science Publishers.

Steiling W.,Henkel AG | Buttgereit P.,ProDERM Institute for Applied Dermatological Research | Hall B.,LOreal | O'Keeffe L.,Procter and Gamble | And 3 more authors.
Food and Chemical Toxicology | Year: 2012

Many cosmetic products are available in spray form. Even though the principal targets of these products are the skin and hair, spraying leads to the partitioning of the product between the target and the surrounding air. In the previous COLIPA study (Hall et al., 2007) the daily use of deodorant/antiperspirant (Deo/AP) in spray form was quantified in terms of the amount of product dispensed from the spray can, without specifically quantifying the product fraction reaching the skin during use. Results of the present study provide this additional information, necessary for a reliable safety assessment of sprayed Deo/AP products. In a novel experimental approach the information obtained from real-life movement analysis (automated motion imaging) of volunteers using their own products was integrated with the aerosol cloud sampling data obtained from the same products, leading to the computation of the product deposited on the skin. The 90th percentile values, expressed as percent deposition relative to the can weight loss after spraying, are 23.5% and 11.4% for ethanol-based and non-ethanol-based products, respectively. Additionally, the study has generated data on the skin area covered by the products, spray duration time, spray angle and spray distance from the skin. © 2012 Elsevier Ltd.

Tan J.,University of Western Ontario | Tan J.,INC Research | Blume-Peytavi U.,Charite - Medical University of Berlin | Ortonne J.P.,Service de Dermatologie Hopital lArchet Cedex 3 | And 6 more authors.
British Journal of Dermatology | Year: 2013

Background Few studies have evaluated differences between rosacea subtypes in epidemiological associations and clinical features. The natural history of rosacea is unknown and progression between subtypes has been implied but not formally evaluated. Objectives To assess associations between the four rosacea subtypes [erythematotelangiectatic (ETR), papulopustular (PPR), phymatous (PHY) and ocular], including quantitative and qualitative details on primary and secondary features of rosacea. A secondary objective was to evaluate for the potential of progression between subtypes. Methods This cross-sectional study recruited subjects with rosacea from Northern Germany and comprised clinical evaluation by a dermatologist and a survey of demographics and onset of rosacea-associated signs and symptoms. Results A total of 135 subjects with rosacea were enrolled. PHY was more frequently associated with PPR than ETR (P < 0·001). Compared with ETR, PPR was significantly associated with facial burning/stinging (P = 0·001), phymas (P < 0·001) and oedema (P < 0·001); and during flushing episodes, was more frequently associated with burning (P = 0·018), skin tension (P = 0·005) and itching (P = 0·027). ETR was more frequently associated with dry facial skin (P < 0·001). Flushing was reported by 66% and the site most frequently involved was the cheeks (100%). Papulopustules were evanescent in 42% and the sites most frequently involved were the cheeks (80%) and nose (67%). Of those fulfilling criteria for at least two subtypes, 66% developed ETR before PPR; 92% developed ETR before PHY; 83% developed PPR before PHY; and the majority developed cutaneous rosacea-associated features before ocular signs/symptoms. Conclusions Significant differences exist between ETR and PPR in rosacea-associated features and in subtype associations. A small proportion of subjects with rosacea may progress between subtypes. What's already known about this topic? Rosacea has been categorized into three cutaneous and one ocular subtype based on primary and secondary clinical features. There is speculation but little data in the literature regarding associations between primary and secondary clinical features and rosacea subtypes, qualitative and quantitative aspects of primary and secondary rosacea-associated features, and progression between rosacea subtypes. What does this study add? This study provides quantitative details on frequency, duration and location of evanescent primary rosacea-associated features - flushing and papulopustules. It demonstrates significant associations in papulopustular rosacea (PPR) with facial burning/stinging, oedema and phymas compared with erythematotelangiectatic rosacea (ETR). During flushing episodes, PPR was more frequently associated with burning, skin tension and itching compared with ETR. Subtype progression was observed in a small proportion of subjects, with ETR progressing to PPR and phymatous rosacea, and PPR progressing to phymatous rosacea. Ocular symptoms developed after rosacea-associated cutaneous features in the majority. © 2013 British Association of Dermatologists.

Bielfeldt S.,ProDERM Institute for Applied Dermatological Research | Henss R.,Dr. Ronald Henss Verlag | Koop U.,Beiersdorf AG | Degwert J.,SIT Skin Investigation and Technology | And 6 more authors.
International Journal of Cosmetic Science | Year: 2013

Synopsis It is well established that decorative cosmetics can enhance female facial attractiveness. In this study, we investigated the effects of a cleanser and a decent foundation on attractiveness of female faces. Comparative rating of a set of facial photographs by a group of lay persons revealed that the cleansing product was significantly reducing the attractiveness of the stimulus persons. Treatment with the foundation increased the attractiveness of the female faces clearly. The authors conclude that even unobtrusive cosmetic treatments like cleansers and light foundations may cause relevant changes of the attractiveness of female faces. © 2012 Society of Cosmetic Scientists.

Waring M.,Devicemark Ltd | Bielfeldt S.,ProDERM Institute for Applied Dermatological Research | Matzold K.,ProDERM Institute for Applied Dermatological Research | Wilhelm K.-P.,ProDERM Institute for Applied Dermatological Research
Skin Research and Technology | Year: 2013

Background: Chronic wounds require frequent dressing changes. Adhesive dressings used for this indication can be damaging to the stratum corneum, particularly in the elderly where the skin tends to be thinner. Understanding the level of damage caused by dressing removal can aid dressing selection. Methods: This study used a novel methodology that applied a stain to the skin and measured the intensity of that stain after repeated application and removal of a series of different adhesive types. Additionally, a traditional method of measuring skin barrier damage (transepidermal water loss) was also undertaken and compared with the staining methodology. Results: The staining methodology and measurement of transepidermal water loss differentiated the adhesive dressings, showing that silicone adhesives caused least trauma to the skin. Conclusion: The staining methodology was shown to be as effective as transepidermal water loss in detecting damage to the stratum corneum and was shown to detect disruption of the barrier earlier than the traditional technique. © 2012 John Wiley & Sons A/S.

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