News Article | December 14, 2016
Montpellier, December 14, 2016 - DEINOVE (Alternext Paris: ALDEI), a biotech company that discovers, develops and produces high value compounds from rare bacteria, notably from the Deinococcus genus, announces that it has validated the 3rd key milestone of its DEINOCHEM program, dedicated to the bio-based production of carotenoids and financed by ADEME (the French Environment and Energy Management Agency) under the "Investissements d'Avenir" (Investments for the Future) program. This new key milestone validates the technical progress made in developing the carotenoid production process. The target thresholds for productivity and yield have been reached using optimized Deinococcus strains on the laboratory scale. Beyond genetic engineering, the following steps are already underway: - Development of a carotenoid extraction and purification process from the fermentation medium to obtain a marketable product; - Scale up of the carotenoid production process for industrial use; - Identification and selection of subcontractors ensuring rapid start-up for production. The Company's ambition is to market its first batches of the target compounds in 2018, and last November it announced that it had selected Processium, an expert in industrial process engineering, to work with on these developments. "We are highly satisfied with these results, which validate the progress obtained in developing our bio-based carotenoids and confirm our strategic choices to refocus our activities on molecules with high added value," declared Emmanuel Petiot, CEO of DEINOVE. "Carotenoids represent market opportunities worth several hundreds of millions of dollars in a wide range of applications in healthcare, nutrition and cosmetics. We are more than ever focused on getting to the market quickly." In accordance with the aid agreement signed in 2013, ADEME's validation that the expected results have been obtained for the deliverables intended in Key Milestone 3 resulted in the payment, early December, of approximately €0.8 million in repayable advances. The DEINOCHEM program targets the production of carotenoids, compounds that are naturally found in many living beings and widely used in industry for their coloring and antioxidant properties. The worldwide carotenoid market is expected to reach $1.8 billion by 2019. In 2013, Europe was the largest market, followed by North America. Applications for these molecules are becoming increasingly diversified in human and animal food, as well as in cosmetics and healthcare. The largest share of production comes from petroleum derivatives, but natural molecules are generating the strongest growth, notably due to consumer demand. Today, there are several production techniques such as extraction from tomatoes (lycopene) or paprika (capsanthin) and bioproduction from algae (astaxanthin) or microorganisms (beta-carotene). The supply of bio-based solutions is nonetheless limited due to their high production costs. DEINOVE's objective is to provide industrials with a competitive, bio-based alternative by developing a carotenoid biotechnological production process and offering significant advantages in terms of supply stability and quality, natural resource conservation and costs. DEINOCHEM, which is expected to require a total investment of €15.9 million by 2018, benefits from €5.9 million in financial support over 3 ans a half years from ADEME and CGI as part of the "Investissements d'Avenir" (Investments for the Future) program. DEINOVE (Alternext Paris: ALDEI) is a biotech company that discovers, develops and produces compounds with industrial value from rare microorganisms, for the healthcare, nutrition and cosmetics markets. These innovative production methods represent a sustainable and competitive alternative. For this, DEINOVE relies on two key assets: Based in Montpellier, DEINOVE employs approximately 50 employees and has nearly 170 international patent applications. The Company has been listed on Alternext since April 2010.
Barreau A.,French Institute of Petroleum |
Brunella I.,French Institute of Petroleum |
De Hemptinne J.-C.,French Institute of Petroleum |
Coupard V.,French Institute of Petroleum |
And 2 more authors.
Industrial and Engineering Chemistry Research | Year: 2010
A good understanding and prediction of the phase equilibrium of the fatty acid methyl ester (FAME) + glycerol + methanol ternary system is needed to design and optimize the separation unit of the biodiesel production process. In this work, new experimental vapor-liquid-liquid data on the ternary system have been measured at temperatures between 333.15 and 473.15 K. In addition, new data have been gathered on the methanol + glycerol [vapor-liquid equilibrium (VLE)] and methanol + methyl oleate (VLE and liquid-liquid equilibrium) binary systems. A group contribution method combined with a statistical associating fluid theory equation of state (GC-PPC-SAFT) proposed earlier by our group (Tamouza, S. Passarello, J.-P. Tobaly, P. and de Hemptinne, J.-C. Group contribution method with SAFT EOS applied to vapor liquid equilibria of various hydrocarbons series. Fluid Phase Equilib. 2004, 222-223, 67-76) and recently extended to predict VLE of heavy esters and their mixtures (Nguyen Huynh, D. Falaix, A. Passarello, J.-P. Tobaly, P. and de Hemptinne, J.-C. Predicting VLE of heavy esters and their mixtures using GC-SAFT. Fluid Phase Equilib. 2008, 264, 184-200) is here applied to model vapor liquid-liquid equilibria of methanol + glycerol + methyl oleate. The SAFT parameters for the glycerol pure component have been regressed using two association schemes (4C and 3X2B). The dispersive binary interaction parameters kij have been regressed on the binary systems. The group contribution scheme was used for predicting the ester properties. © 2010 American Chemical Society.
News Article | November 14, 2016
Paris, France, Nov. 14, 2016 (GLOBE NEWSWIRE) -- DEINOVE SIGNS A PARTNERSHIP WITH PROCESSIUM TO PREPARE FOR THE INDUSTRIALIZATION OF ITS CAROTENOID PRODUCTION PROCESS Montpellier, November 14, 2016 - DEINOVE (Alternext Paris: ALDEI), a biotech company that discovers, develops and produces high-value compounds from rare bacteria, notably from the Deinococcus genus, announces that it has chosen Processium, an expert in industrial process engineering, to develop carotenoid separation/purification techniques at an industrial scale and to transpose the production process from the laboratory to industry. DEINOVE plans to market the carotenoids produced directly to the healthcare, nutrition and cosmetics industrials. This business is expected to start generating revenue in 2018. In 2016, DEINOVE obtained proof of concept for the production of carotenoid molecules from optimized Deinococcus strains: One of DEINOVE's strategic goals is to market carotenoids in the form of ingredients directly to the industrials of its target markets. DEINOVE does not have plans to develop its own manufacturing facilities, but will subcontract production, including the large-scale fermentation, extraction, purification and formulation stages. DEINOVE therefore chose Processium, an industrial process engineering firm headquartered in Lyon that works in the chemistry and biotech fields. The experts at Processium will have two major missions with DEINOVE: - developing and validating an industrial process for extracting carotenoids from the fermentation medium to obtain a marketable product; - identifying and selecting subcontractors who can start production quickly. "With the benefits of Processium's technical expertise and geographical proximity, DEINOVE is moving forward in its ambition to quickly market its first carotenoids, which should start generating revenue in 2018. Like us, Processium works in the chemistry, pharmaceuticals and cosmetics fields and we share the same values and challenges - saving time so we can get our first products to market quickly and optimizing our carotenoid production units in terms of economic and environmental performances," said Emmanuel PETIOT, CEO of DEINOVE. Pascal ROUSSEAUX, CEO of Processium, added, "We are delighted to work with DEINOVE and to contribute to speeding up their Carotenoid project. DEINOVE's key expertise in the fermentation, whereas ours comes into play after the fermentation step, when it comes to separate and purify the compound to be sold. DEINOVE has reached a milestone, now developing an industrial process based on the production process designed and optimized in the laboratory." DEINOVE (Alternext Paris: ALDEI) is a biotech company that discovers, develops and produces compounds with industrial value from rare bacteria, for the healthcare, nutrition and cosmetics markets. These innovative production methods represent a sustainable and competitive alternative. For this, DEINOVE relies on two key assets: Based in Montpellier, DEINOVE employs approximately 50 employees and has nearly 170 international patent applications. The Company has been listed on Alternext since April 2010.
Oprisiu I.,CNRS Strasbourg Institute of Chemistry |
Marcou G.,CNRS Strasbourg Institute of Chemistry |
Horvath D.,CNRS Strasbourg Institute of Chemistry |
Brunel D.B.,Processium |
And 2 more authors.
Thermochimica Acta | Year: 2013
Quantitative structure-property models to predict the normal boiling point (Tb) of organic compounds were developed using non-linear ASNNs (associative neural networks) as well as multiple linear regression-ISIDA-MLR and SQS (stochastic QSAR sampler). Models were built on a diverse set of 2098 organic compounds with Tb varying in the range of 185-491 K. In ISIDA-MLR and ASNN calculations, fragment descriptors were used, whereas fragment, FPTs (fuzzy pharmacophore triplets), and ChemAxon descriptors were employed in SQS models. Prediction quality of the models has been assessed in 5-fold cross validation. Obtained models were implemented in the on-line ISIDA predictor at http://infochim.u-strasbg.fr/webserv/VSEngine.html. © 2012 Elsevier B.V.
News Article | April 6, 2016
« Audi refreshes A3 with new engines, driver assistance systems, virtual cockpit | Main | U-Michigan, IBM collaborate on data-centric high performance computing system » Global Bioenergies has purified its bio‐isobutene to 99.77%, a polymer‐grade level. Global Bioenergies routinely produces isobutene batches using its industrial pilot located in Pomacle‐Bazancourt, eastern France. Up to now, 95% purity was reached, a level sufficient for several applications, such as fuels and paints. For the first time, with the help of Processium, a chemical engineering company headquartered in Lyon, France, Global Bioenergies was able to purify batches to a much higher level, reaching 99.77%, the remaining 0.23% being mostly composed of CO , an inert gas known to be neutral in most chemical reactions. Several applications in the polymers business (rubbers, plastics...) require high‐purity isobutene, and 99.77% corresponds to the polymer‐grade standard. We expect that our high‐purity bio‐isobutene will meet the specifications of the industrial leaders involved in converting isobutene into polymers, and that they will be able to use their existing polymerization processes, designed for fossil feedstocks, without any significant change. The higher the purity, the higher the value: targeting higher‐value markets is especially important in the present oil and gas environment. Global Bioenergies is developing processes to convert renewable resources into hydrocarbons through fermentation. The company initially focused its efforts on the production of isobutene, one of the most important petrochemical building blocks that can be converted into fuels, plastics, organic glass and elastomers.
Jarne C.,MINES ParisTech |
Jarne C.,CSIC - Institute of Carbochemistry |
Rivollet F.,Processium |
Richon D.,MINES ParisTech
Journal of Chemical and Engineering Data | Year: 2011
Pressure, density, and temperature (PρT) data are presented for two compositions (z1 = 0.2227 and 0.2691) of the hydrogen sulfide (1) + propane (2) binary mixture at three temperatures in vapor and liquid states from a vacuum up to 40 MPa. Experimental work was achieved thanks to a vibrating-tube densimeter using the forced path mechanical calibration model (FPMC). The Lee-Kesler-Plöcker model was chosen with one temperature-dependent binary interaction parameter to represent our experimental data. Observed deviations on liquid and vapor densities (between experimental and calculated data) are less than 2 % on both liquid and vapor phases except for data close to the critical point. © 2010 American Chemical Society.
Zhang F.,MINES ParisTech |
Theveneau P.,MINES ParisTech |
El Ahmar E.,MINES ParisTech |
Canet X.,PROCESSIUM |
And 2 more authors.
Fluid Phase Equilibria | Year: 2016
An improved apparatus based on the static-analytic method for reliable vapor-liquid equilibrium (VLE) data measurement is presented in this work. It has been applied to investigate systems containing organic sulfur compounds. New sampling mechanisms were combined with ROLSI™ capillary samplers to achieve on-line sampling for both vapor and liquid phases in a pressure range between 0.1 and 10 bar. Phase samples were directly sent to a gas chromatograph for composition analysis. The equipment was tested against other commonly used experimental methods in this pressure range on the (. n-butane + ethanol) and (diethyl sulfide + ethanol) systems. The obtained data were correlated by Wilson model and compared with existing data. The improved apparatus has shown comparable performances to existing methods, while showing some advantages such as complete PTxy phase measurements and less product consumption. After the validation step, additional VLE data for binary systems of interest, (diethyl sulfide + n-butane) and (1-pentanethiol + 1-pentanol), were reported and modeled in this work. © 2015 Elsevier B.V.
News Article | November 14, 2016
MONTPELLIER, France--(BUSINESS WIRE)--Regulatory News: DEINOVE (Paris:ALDEI), a biotech company that discovers, develops and produces high-value compounds from rare bacteria, notably from the Deinococcus genus, announces that it has chosen Processium, an expert in industrial process engineering, to develop carotenoid separation/purification techniques at an industrial scale and to transpose the production process from the laboratory to industry. DEINOVE plans to market the carotenoids produced