Allian A.,Process Research and Development
ACS Symposium Series | Year: 2014
The formation of carbonyl compounds via oxidative cleavage of alkenes is an important synthetic step in API production. Ozone is an excellent oxidizing agent to perform this synthesis and is more efficient and environmentally friendly to current oxidation protocols that employ toxic metals. However, the exofhermicity of ozonolysis reaction along with the instability of the intermediate involved hinders its implementation at scale in batch mode. In this chapter, we demonstrate that carrying out ozonolysis in continuous mode successfully addresses these safety thermal hazard concerns. © 2014 American Chemical Society.
Lisberger M.,Nurnberg University of Applied Sciences |
Hagn S.,Process Research and Development |
Scheuringer H.,Scheuch GmbH
ZKG International | Year: 2012
Gebr. PfeitTer SE has developed a forward-looking concept for a new mill and a new drive. The new MVR vertical roller mill for grinding cement raw material, cement and granulated blast furnace slag has a modular design, which enables operation to be continued even if one roller module fails. The new MultiDrive® drive system, which consists of up to six identically sized drive units, incorporates the same actively redundant design principle as the mill's roller modules. This significantly reduces unplanned stoppage times, even in the case of main component failure. The main components of the MVR vertical roller mill are the four or six grinding rollers with a cylindrical wear part geometry, the flat grinding table, the gas-guiding housing with nozzle ring and classifier and the drive, which can optionally consist of the MultiDrive® or of a conventional drive system with planetary gear unit. The load distribution to the individual electric motors is performed by a primary control system through frequency converters associated with each drive module.
Thomson N.M.,Pfizer |
Seibert K.D.,Eli Lilly and Company |
Tummala S.,Bristol Myers Squibb |
Bordawekar S.,Process Research and Development |
And 4 more authors.
Organic Process Research and Development | Year: 2015
A number of strategies have been employed within the pharmaceutical industry in order to mitigate the risk of applying design space boundaries developed on the laboratory scale to commercial drug substance manufacturing. The following communication presents a number of case histories from members of the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ), with the aim of exemplifying strategies used to confirm applicability of design spaces developed on the laboratory scale. The strategies presented have a common aim of ensuring that appropriate quality standards are developed, maintained, and enhanced during the product lifecycle whilst delivering rapid and cost-effective mechanisms for drug substance commercialization. © 2014 American Chemical Society.
Kim S.-H.,Bristol Myers Squibb |
De Mas N.,Process Research and Development |
De Mas N.,Lonza Biologics Inc. |
Parlanti L.,Process Research and Development |
And 20 more authors.
Organic Process Research and Development | Year: 2011
We describe the synthesis, chromatographic purification, and isolation of the epothilone-folic acid conjugate BMS-753493, an investigational new drug candidate for the treatment of cancer. The main challenges for process development were the instability of BMS-753493 in aqueous solution, the design and optimization of the preparative chromatography, and the removal of phosphate salts and water from the purified material. The operating conditions of the batch chromatographic purification were optimized using a column adsorption model. The free-salt active pharmaceutical ingredient was isolated via the precipitation of its zwitterion following a careful determination of the isolation parameters that controlled thermal and pH-related decomposition. This process enabled the manufacturing of several batches (10-30 g) of cGMP quality BMS-753493. © 2011 American Chemical Society.
Cullen S.C.,Process Research and Development |
Shekhar S.,Process Research and Development |
Nere N.K.,Process Research and Development
Journal of Organic Chemistry | Year: 2013
A convenient method for the preparation of aryl trifluoromethylsulfones from the reactions of diaryliodonium salts with sodium trifluoromethanesulfinate in the presence of copper catalysts is described. Cuprous oxide in DMF was found to be the optimal catalyst for the reaction. The reaction conditions are tolerant of various functional groups as well as of various counteranions of the iodonium salt. The synthetic utility of the process is demonstrated by performing the reaction on a preparative scale (88 g). © 2013 American Chemical Society.