Stuttgart, Germany
Stuttgart, Germany

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PubMed | Moravian Museum, Museum dHistoire naturelle Geneva, Dermestidae World, Centro Nazionale Per Lo Studio E La Conservazione Della Biodiversita Forestale Bosco Fontana Of Verona and 30 more.
Type: | Journal: Biodiversity data journal | Year: 2015

Fauna Europaea provides a public web-service with an index of scientific names (including synonyms) of all living European land and freshwater animals, their geographical distribution at country level (up to the Urals, excluding the Caucasus region), and some additional information. The Fauna Europaea project covers about 230,000 taxonomic names, including 130,000 accepted species and 14,000 accepted subspecies, which is much more than the originally projected number of 100,000 species. This represents a huge effort by more than 400 contributing specialists throughout Europe and is a unique (standard) reference suitable for many users in science, government, industry, nature conservation and education. Coleoptera represent a huge assemblage of holometabolous insects, including as a whole more than 200 recognized families and some 400,000 described species worldwide. Basic information is summarized on their biology, ecology, economic relevance, and estimated number of undescribed species worldwide. Little less than 30,000 species are listed from Europe. The Coleoptera 2 section of the Fauna Europaea database (Archostemata, Myxophaga, Adephaga and Polyphaga excl. the series Elateriformia, Scarabaeiformia, Staphyliniformia and the superfamily Curculionoidea) encompasses 80 families (according to the previously accepted family-level systematic framework) and approximately 13,000 species. Tabulations included a complete list of the families dealt with, the number of species in each, the names of all involved specialists, and, when possible, an estimate of the gaps in terms of total number of species at an European level. A list of some recent useful references is appended. Most families included in the Coleoptera 2 Section have been updated in the most recent release of the Fauna Europaea index, or are ready to be updated as soon as the FaEu data management environment completes its migration from Zoological Museum Amsterdam to Berlin Museum fr Naturkunde.


PubMed | University of Mons, Natural History Museum in London, Museum of Biological Diversity, Schmalhausen Institute of Zoology and 14 more.
Type: | Journal: Biodiversity data journal | Year: 2015

Fauna Europaea provides a public web-service with an index of scientific names (including important synonyms) of all living European land and freshwater animals, their geographical distribution at country level (up to the Urals, excluding the Caucasus region), and some additional information. The Fauna Europaea project covers about 230,000 taxonomic names, including 130,000 accepted species and 14,000 accepted subspecies. This represents a huge effort by more than 400 contributing specialists throughout Europe and is a unique (standard) reference suitable for many users in science, government, industry, nature conservation and education. Hymenoptera is one of the four largest orders of insects, with about 130,000 described species. In the Fauna Europaea database, Hymenoptera - Apocrita (excluding Ichneumonoidea) comprises 13 superfamilies, 52 families, 91 subfamilies, 38 tribes and 13,211 species. The paper includes a complete list of taxa dealt with, the number of species in each and the name of the specialist responsible for data acquisition. As a general conclusion about the European fauna of Hymenoptera, the best known countries in terms of recorded species are those from northwestern Europe, with the least known fauna probably in the more eastern and southeastern parts of Europe.


Ehmke N.,Charité - Medical University of Berlin | Caliebe A.,University of Kiel | Koenig R.,Goethe University Frankfurt | Kant S.G.,Leiden University | And 31 more authors.
American Journal of Human Genetics | Year: 2014

Catel-Manzke syndrome is characterized by Pierre Robin sequence and a unique form of bilateral hyperphalangy causing a clinodactyly of the index finger. We describe the identification of homozygous and compound heterozygous mutations in TGDS in seven unrelated individuals with typical Catel-Manzke syndrome by exome sequencing. Six different TGDS mutations were detected: c.892A>G (p.Asn298Asp), c.270-271del (p.Lys91Asnfs∗22), c.298G>T (p.Ala100Ser), c.294T>G (p.Phe98Leu), c.269A>G (p.Glu90Gly), and c.700T>C (p.Tyr234His), all predicted to be disease causing. By using haplotype reconstruction we showed that the mutation c.298G>T is probably a founder mutation. Due to the spectrum of the amino acid changes, we suggest that loss of function in TGDS is the underlying mechanism of Catel-Manzke syndrome. TGDS (dTDP-D-glucose 4,6-dehydrogenase) is a conserved protein belonging to the SDR family and probably plays a role in nucleotide sugar metabolism. © 2014 The American Society of Human Genetics.


PubMed | Massachusetts Institute of Technology, USAMRIID, Pablo De Olavide University, National Technical University of Athens and 18 more.
Type: | Journal: F1000Research | Year: 2015

The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airways for which therapeutic options currently are limited after diagnosis, even in its earliest stage. COPD network models are important tools to better understand the biological components and processes underlying initial disease development. With the increasing amounts of literature that are now available, crowdsourcing approaches offer new forms of collaboration for researchers to review biological findings, which can be applied to the construction and verification of complex biological networks. We report the construction of 50 biological network models relevant to lung biology and early COPD using an integrative systems biology and collaborative crowd-verification approach. By combining traditional literature curation with a data-driven approach that predicts molecular activities from transcriptomics data, we constructed an initial COPD network model set based on a previously published non-diseased lung-relevant model set. The crowd was given the opportunity to enhance and refine the networks on a website ( https://bionet.sbvimprover.com/) and to add mechanistic detail, as well as critically review existing evidence and evidence added by other users, so as to enhance the accuracy of the biological representation of the processes captured in the networks. Finally, scientists and experts in the field discussed and refined the networks during an in-person jamboree meeting. Here, we describe examples of the changes made to three of these networks: Neutrophil Signaling, Macrophage Signaling, and Th1-Th2 Signaling. We describe an innovative approach to biological network construction that combines literature and data mining and a crowdsourcing approach to generate a comprehensive set of COPD-relevant models that can be used to help understand the mechanisms related to lung pathobiology. Registered users of the website can freely browse and download the networks.


Ziemke C.,University of Stuttgart | Kuwahara T.,Tohoku University | Kossev I.,Private
61st International Astronautical Congress 2010, IAC 2010 | Year: 2010

Even in the field of small satellites, the on-board data handling subsystem has become complex and powerful. With the introduction of powerful CPUs and the availability of considerable quantities of memory on-board a small satellite it has become possible to utilize the flexibility and power of contemporary platform-independent real-time operating systems. Especially the non commercial sector like university institutes and community projects such as AMSAT or SSETI are characterized by the inherent lack of financial as well as manpower resources. The opportunity to utilize such real-time operating systems will contribute significantly to achieve a successful mission. Nevertheless the on-board software (OBSW) of a satellite is much more than just an operating system. It has to fulfil a multitude of functional requirements such as: Telecommand interpretation and execution, execution of control loops, generation of telemetry data and frames, failure detection isolation and recovery, the communication with peripherals and so on. Most of the aforementioned tasks are of generic nature and have to be conducted on any satellite with only minor modifications. A general set of functional requirements as well as a protocol for communication is defined in the ESA ECSS-E-70-41A standard "Telemetry and telecommand packet utilization". This standard not only defines the communication protocol of the satellite-ground link but also defines a set of so called services which have to be available on-board of every compliant satellite and which are of a generic nature. In this paper a platform-independent and reusable framework is described which is implementing not only the ECSS-E-70-41A standard but also functionalities for inter-process communication, scheduling and a multitude of tasks commonly performed on-board of a satellite. By making use of the capabilities of the high-level programming language C/C++, the powerful open source library BOOST, the real-time operating system RTEMS and finally by providing generic functionalities compliant to the ECSS-E-70-41A standard the proposed framework can provide a great boost in productivity. Together with open source tools such like the GNU tool-chain, Eclipse SDK, the simulation framework OpenSimKit, the emulator QEMU, the proposed OBSW framework forms an integrated development framework. It is possible to design, code and build the on-board software together with the operating system and then run it on a simulated satellite for performance analysis and debugging purposes. This makes it possible to rapidly develop and deploy a full-fledged satellite OBSW with minimal cost and in a limited time frame. Copyright ©2010 by Claas Ziemke. Published by the American Institute of Aeronautics and Astronautics, Inc.


Mayseless M.,iML Inc | Hirsch E.,Private
25th International Symposium on Ballistics, ISB 2010 | Year: 2010

The mass density of charge jets formed from porous liners, made of compressed powder, diminishes with ongoing time of flight. A model was developed based on the assumption that each jet element acquires a radial velocity component, V^ , due to a friction mechanism inside the jet. Comparing the developed model results, by employing the SCAN semi- analytical code, with the experimental data of a penetration depth of a porous jet versus time, we found that agreement with the data for Vn = 3.8 m/sec was excellent. With this fitted value the SCAN code yielded the characteristics of the jet parameters' change as a function of the penetration, explaining the source of the benefit of using porous liners in the penetration of concrete and sediment materials. The model opens the way to detailed analysis of where and when the use of porous liners is preferable to the use of solid ones, and vice versa. The details are explained in fiill in the complete paper.


Klauer B.,Helmholtz Center for Environmental Research | Schiller J.,Helmholtz Center for Environmental Research | Bathe F.,Private
Journal of Environmental Planning and Management | Year: 2015

The EU Water Framework Directive calls for cost effective measures to achieve a “good status” in all European ground, surface and coastal waters. Besides eutrophication, the degradation of hydromorphology is the main reason for failing this objective. In this paper, we conceptualise the interactive decision support process BASINFORM-M for finding proper locations for river restoration. The concept combines the recently proposed “stepping stone approach” from aquatic ecology with elements from cost effectiveness analysis, multi-criteria analysis and participatory approaches. BASINFORM-M exemplifies a shift away from the isolated restoration of single river reaches towards a consideration of functional relationships within river networks. © 2014 University of Newcastle upon Tyne.


Lee S.-W.,RIKEN | Lee S.-W.,Kyushu University | Feugier F.G.,Private | Morishita Y.,RIKEN
Journal of Theoretical Biology | Year: 2014

Vein formation is an important process in plant leaf development. The phytohormone auxin is known as the most important molecule for the control of venation patterning; and the canalization model, in which cells experiencing higher auxin flux differentiate into specific cells for auxin transportation, is widely accepted. To date, several mathematical models based on the canalization hypothesis have been proposed that have succeeded in reproducing vein patterns similar to those observed in actual leaves. However, most previous studies focused on patterning in fixed domains, and, in a few exceptional studies, limited tissue growth - such as cell proliferation at leaf margins and small deformations without large changes in cell number - were dealt with. Considering that, in actual leaf development, venation patterning occurs in an exponentially growing tissue, whether the canalization hypothesis still applies is an important issue to be addressed. In this study, we first show through a pilot simulation that the coupling of chemical dynamics for canalization and tissue growth as independent models cannot reproduce normal venation patterning. We then examine conditions sufficient for achieving normal patterning in a growing leaf by introducing various constraints on chemical dynamics, tissue growth, and cell mechanics; in doing so, we found that auxin flux- or differentiation-dependent modification of the cell cycle and elasticity of cell edges are essential. The predictions given by our simulation study will serve as guideposts in experiments aimed at finding the key factors for achieving normal venation patterning in developing plant leaves. © 2014 The Authors.

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