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Nagabalasubramanian P.B.,PRIST University | Karabacak M.,Afyon Kocatepe University | Periandy S.,Tagore Arts College
Journal of Molecular Structure | Year: 2012

The FT-IR and FT-Raman spectra of nicotinic acid ethyl ester (abbreviated as NAEE, C8H9NO2) have been recorded in the region 3600-10 cm-1. Potential energy curve was computed by means of scanning CCCO torsion angle. The optimized geometric parameters geometry optimization and the energies associated possible two conformers (C1 and C2) were computed. The computational results diagnose the most stable conformer of NAEE as the C1 form. The optimum molecular geometries, energies, normal mode wavenumbers, infrared and Raman intensities, corresponding vibrational assignments, atomic charges, HOMO-LUMO analysis and thermo-dynamical parameters were investigated with the help of HF, B3LYP and LSDA methods with 6-311G(d,p) and 6-311G++(d,p) basis sets. Reliable vibrational assignments were made on the basis of total energy distribution (TED) calculated with scaled quantum mechanics (SQM) method. Thermodynamic properties of the title compound at different temperatures were calculated. The results of the calculations were applied to simulate infrared and Raman spectra of the title compound which show excellent agreement with the observed spectra. © 2012 Elsevier B.V. All rights reserved.


Elangovan K.,PRIST University
International Conference on Pattern Recognition, Informatics and Medical Engineering, PRIME 2012 | Year: 2012

Orthogonal Frequency Division Multiplexing (OFDM) has recently been applied in wireless communication systems due to its high data rate transmission capability with high bandwidth efficiency and its robustness to multi-path delay. Fading is the one of the major aspect which is considered in the receiver. To cancel the effect of fading, channel estimation and equalization procedure must be done at the receiver before data demodulation. In this paper dealt the comparisons of various algorithms, complexity and advantages, on the capacity enhancement for OFDM systems channel estimation techniques. Mainly three prediction algorithms are used in the equalizer to estimate the channel responses namely, Least Mean Square (LMS), Normalized Least Mean Square (NLMS) and Recursive Least Square (RLS) algorithms. These three algorithms are considered in this work and performances are statically compared by using MATLAB Software. © 2012 IEEE.


Selvamangai G.,Alpha Arts and Science College | Bhaskar A.,PRIST University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To characterize the phytochemical constituents of Eupatorium triplinerve using GC -MS. Methods: Ten grams of the powdered sample was subjected to column chromatography over silica gel (100-200 mesh) and eluted with n-hexane, chloroform, ethanol and methanol respectively. n-Hexane and Chloroform did not elute much of the compounds. The methanol fraction of the Eupharbatum triplinerve was taken for GC-MS analysis. The analysis was carried out on a GC Clarus 500 GC system with a column packed with Elite - 1 (10% dimethyl poly siloxane, 30 × 0.25 mm ID × 1 EM df), the compounds are separated using with Helium as carrier gas at a constant flow 1ml/min. sample extract (2 μL) injected into the instrument was detected by Turbo gold mass detector (Perkin Elmer) with the aid of the Turbo mass 5.1 software. Results: The GC MS analysis provided peaks of eleven different phytochemical compounds namely hexadecanoic acid (14.65%), 2,6,10-trimethyl,14-ethylene-14-pentadecne (9.84%), Bicyclo[4.1.0]heptane, 7-butyl-(2.38%), Decanoic acid, 8-methyl-, methyl ester (3.86%), 1-undecanol (7.82%), 1-hexyl-1-nitrocyclohexane (2.09%), 1,14-tetradecanediol (6.78%), Octadecanoic acid, 2-hydroxy-1,3-propanediyl ester (19.18%) and 2-hydroxy-3-[(9E)-9-octadecenoyloxy] propyl(9E)-9-octadecenoate (8.79%). Conclusions: The bioactive compounds in the methanolic extract of Eupatorium triplinerve have been screened using this analysis. Isolation of individual components would however, help to find new drugs. © 2012 Asian Pacific Tropical Biomedical Magazine.


Bhaskar A.,PRIST University | Nithya V.,Srimad Andavan College
Indian Journal of Pharmacology | Year: 2012

Objective: To investigate the wound-healing potency of the ethanolic extract of the flowers of Hibiscus rosa sinensis. Materials and Methods: The wound-healing activity of H. rosa sinensis (5 and 10% w/w) on Wistar albino rats was studied using three different models viz., excision, incision and dead space wound. The parameters studied were breaking strength in incision model, granulation tissue dry weight, breaking strength and collagen content in dead space wound model, percentage of wound contraction and period of epithelization in excision wound model. The granulation tissue formed on days 4, 8, 12, and 16 (post-wound) was used to estimate total collagen, hexosamine, protein, DNA and uronic acid. Data were analyzed by Analysis of Variance (ANOVA) test. P<0.05 was considered statistically significant. Results: The extract increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in DNA, total protein and total collagen content of granulation tissues. The extract-treated wounds were found to heal much faster as indicated by improved rates of epithelialization and wound contraction. The extract of H. rosa sinensis significantly (P<0.001) increased the wound-breaking strength in the incision wound model compared to controls. The extract-treated wounds were found to epithelialize faster, and the rate of wound contraction was significantly (P<0.001) increased as compared to control wounds. Wet and dry granulation tissue weights in a dead space wound model increased significantly (P<0.001). There was a significant increase in wound closure rate, tensile strength, dry granuloma weight, wet granuloma weight and decrease in epithelization period in H. rosa sinensis-treated group as compared to control and standard drug-treated groups. Conclusion: The ethanolic extract of H. rosa sinensis had greater wound-healing activity than the nitrofurazone ointment.


Balamurugan K.,PRIST University | Karthikeyan J.,PRIST University
Indian Journal of Clinical Biochemistry | Year: 2012

Hepatocellular carcinoma (HCC) is one of the commonest tumors worldwide. The treatment of HCCisvital for disease diagnosis and prognosis, as the liver is the most important organ controlling metabolic functions. Now-a-days, western folklore medicines are largely dependent on the phyto compounds which are highly effective in therapy and with low side effects. Luteolin is a flavonoid (3,4,5,7-Tetrahydro flavones) possess anti-inflammatory, anticancer and anti allergic property. The present study evaluates the efficacy of luteolin against N-nitrosodiethylamine (DEN) induced HCC in albino rats. In the highlight of the above, luteolin was evaluated for its efficacy against DEN induced HCC in male Wistar albino rats. The Biochemical parameters such as tissue damaging enzymes viz., AST, ALP, LDH and γ-GT, enzymatic antioxidants viz., SOD, CAT, GSH and GPx and histopathological changes have been estimated. The tissue damaging enzymes were found to be high in DEN alone treated group whereas the enzymatic antioxidants decreased destructively. Severe lesions and cirrhosis were observed in the toxin (DEN alone) treated group. The lute-olin treated DEN group altered the tissue damaging enzymes and the enzymatic antioxidants. The damaged lesion in the histoarchitecture of DEN treated rat liver was almost completely restored. Finallythis study strongly demonstrates that luteolin has potent curative property against HCC in albino rats. © 2012 Association of Clinical Biochemists of India.


Nagabalasubramanian P.B.,PRIST University | Karabacak M.,Afyon Kocatepe University | Periandy S.,Tagore Arts College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

In this work, the FT-IR and FT-Raman spectrum of 1-(chloromethyl)-2-methyl naphthalene (abbreviated as 1-ClM-2MN, C 12H 11Cl) have been recorded in the region 3600-10 cm -1. The optimum molecular geometry, normal mode wavenumbers, infrared and Raman intensities, Raman scattering activities, corresponding vibrational assignments, Mullikan atomic charges and thermo-dynamical parameters were investigated with the help of HF and B3LYP (DFT) method using 6-311G(d,p), 6-311++G(d,p) basis sets. Also, the dipole moment, linear polarizabilities, anisotropy, first and second hyperpolarizabilities values were also computed using the same basis set. Reliable vibrational assignments were made on the basis of total energy distribution (TED) calculated with scaled quantum mechanical (SQM) method. The correlation equations between heat capacities, entropies, enthalpy changes and temperatures were fitted by quadratic formulas. Lower value in the HOMO and LUMO energy gap explains the eventual charge transfer interactions taking place within the molecule. UV-vis spectral analysis of 1-ClM-2MN has been researched by theoretical calculations. In order to understand the electronic transitions of the compound, TD-DFT calculations on electronic absorption spectra in gas phase and solvent (DMSO and chloroform) were performed. The calculated frontier orbital energies, absorption wavelengths (λ), oscillator strengths (f) and excitation energies (E) for gas phase and solvent are also illustrated. © 2011 Elsevier B.V. All rights reserved.


Nagabalasubramanian P.B.,PRIST University | Karabacak M.,Afyon Kocatepe University | Periandy S.,Tagore Arts College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2011

In this work, the FT-IR and FT-Raman spectra of 1-naphthaleneacetic acid methyl ester (abbreviated as 1-NAAME, C 10H 7CH 2CO 2CH 3) have been recorded in the region 3600-10 cm -1. The optimum molecular geometry, normal mode wavenumbers, infrared and Raman intensities, Raman scattering activities, corresponding vibrational assignments, Mullikan atomic charges and other thermo-dynamical parameters were investigated with the help of HF and B3LYP (DFT) method using 6-31G(d,p), 6-311G(d,p) basis sets. Reliable vibrational assignments were made on the basis of total energy distribution (TED) calculated with scaled quantum mechanical (SQM) method. From the calculations, the molecules are predicted to exist predominantly as the C1 conformer. The correlation equations between heat capacity, entropy, enthalpy changes and temperatures were fitted by quadratic formulae. Lower value in the HOMO and LUMO energy gap explains the eventual charge transfer interactions taking place within the molecule. UV-VIS spectral analyses of 1NAAME have been researched by theoretical calculations. In order to understand electronic transitions of the compound, TD-DFT calculations on electronic absorption spectra in gas phase and solvent (DMSO and chloroform) were performed. The calculated frontier orbital energies, absorption wavelengths (λ), oscillator strengths (f) and excitation energies (E) for gas phase and solvent (DMSO and chloroform) are also illustrated. © 2011 Elsevier B.V. All rights reserved.


Talluri S.,South Dakota School of Mines and Technology | Raj S.M.,South Dakota School of Mines and Technology | Raj S.M.,PRIST University | Christopher L.P.,South Dakota School of Mines and Technology
Bioresource Technology | Year: 2013

The abilities of the extreme thermophilic bacterium Caldicellulosiruptor saccharolyticus DSM 8903 to ferment switchgrass (SWG), microcrystalline cellulose (MCC) and glucose to hydrogen (H2) in one-step were examined. Hydrogen production from glucose reached the theoretical maximum for dark fermentation of 4mol H2/mol glucose. The H2 yield on MCC and SWG after 6days of fermentation was 23.2mmol H2/L or 9.4mmol H2/g MCC and 14.3mmol H2/L or 11.2mmol H2/g SWG, respectively. The rate of H2 formation however was higher on MCC (0.7mmol/Lh) than SWG (0.1mmol/Lh). C. saccharolyticus DSM 8903 was able to produce H2 directly from mechanically-comminuted SWG without any physicochemical or biological pretreatment. Combining four processing steps (pretreatment, enzyme production, saccharification and fermentation) into a single biorefinery operation makes C. saccharolyticus DSM 8903 a promising candidate for consolidated bioprocessing (CBP) of lignocellulosic biomass. © 2013 Elsevier Ltd.


Nagabalasubramanian P.B.,Arignar Anna Government Arts College | Periandy S.,Tagore Arts College | Mohan S.,PRIST University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

The FT-IR and FT-Raman vibrational spectra of α-chlorotoluene have been recorded using Perkin-Elmer 180 spectrometer in the range 3600-10 cm -1 in the solid phase. A detailed vibrational spectral analysis has been carried out and assignments of the observed fundamental bands have been proposed on the basis of peak positions and relative intensities. The optimized molecular geometry, vibrational frequencies, atomic charges, dipole moment, rotational constants and several thermodynamic parameters in the ground state were calculated using ab initio Hartree-Fock (HF) and Density Functional B3LYP methods (DFT) with 6-311G(d) and 6-311++G(d) basis sets. With the help of specific scaling procedures, the observed vibrational wavenumbers in FT-IR and FT-Raman spectra were analyzed and assigned to different normal modes of the molecule. Most of the modes have wavenumbers in the expected range. The results of the calculations were applied to simulated infrared and Raman spectra of the title compound which showed excellent agreement with the observed spectra. © 2010 Elsevier B.V.


RajaRajan A.,PRIST University
ICECT 2011 - 2011 3rd International Conference on Electronics Computer Technology | Year: 2011

This paper is regarding an XML based language to perform artificial neural network application (ANN). Here we see how Neural XML (NXML) can be used for an 'intelligent' task that is for identifying images based on various criteria with an example of interesting 'pseudo' brain disorder detection. This is the model in which artificial neural networks are based. Thus far, artificial neural networks haven't even come close to modeling the complexity of the brain, but they have shown to be good at problems which are easy for a human but difficult for a traditional computer, such as image recognition and predictions based on past knowledge. The algorithm which we use here is BPN. Back-propagation is well suited to pattern recognition problems. In this study we considered a perceptron based feed forward neural network for the detection of brain disorder. © 2011 IEEE.

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