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Thanjāvūr, India

Balamurugan K.,Prist University
International Journal of Applied Chemistry

A sensitive, simple, specific, precise, accurate and rugged method for determination of enantiomeric impurity of 1-Ephedrine Sulfate (1-EPS) a drugs substance has been developed. The separation of isomer is by Diacel, Chiralpak AD-H 250mm × 4.6 mm with 5μ, particle size[6]. Column was maintained at 25°C The UV/Vis detector was operated at 254 nm. Flow rate of the mobile phase was 2.0 ml/min. The method offers excellent separation of two enentiomers with resolution (R) is not less than 2. The method was validated for the quantification of d-Ephedrine enantiomeric impurity (d-EPS) in the bulk drug, was performed according to the International Conference on Harmonization (ICH) guidelines [1-4]. Calibration curves showed excellent linearity over the concentration range 0.02 to 0.1 mg/ml (0.4% to 2.0 %) for dEPS. Precision of the method, the relative standard deviation was 0.99%.limit of detection (LOD) and limit of quantification (LOQ) of the method for d-EPS were 0.04% and 0.16% respectively. Average recovery of the d-EPS was 107.48%. This method was employed in determining enantiomeric impurity of bulk drug 1-EPS. © Research India Publications. Source

Abraham P.,Prist University | Paridhavi M.,Rajiv Gandhi Institute Of Pharmacy Trikkaripur
Asian Journal of Pharmaceutical and Clinical Research

Ayurvedic medicines are the combinations of selected herbal drugs and are manufactured under different pharmaceutical processes to result in various dosage forms such as churnas, bhasmas, liquid, lehas, pill, tablet etc. Churna is defined as a fine powder of drug or drugs in ayurvedic system of medicine. The churna is free flowing and retains its potency for one year, if preserved in airtight containers. Churna formulations are similar to powder formulations in allopathic system of medicine. In recent days churna is formulated into tablets in order to fix the dose easily. These forms of medicament are prescribed generally because of their particle size. Smaller the particle size greater is the absorption rate from g.i.t and hence the greater is bioavailability. Herbal medicine has been enjoying renaissance among the customers throughout the world. Ayurvedic principles show that everyone has a particular personality type as shown by the make up of their dos has, or inner life energies. Your prakriti is your make up when you were born, and vikruti is what they are now as a result of life's experiences and stresses and imbalances of other elemental influences. In order to correct these derangements, one can use churnas, or Ayurvedic spice powders that are made up of blends of spices. These churnas are made of fresh herbs that have medicinal properties, as well as the ability to neutralize the toxic effects caused by imbalances within the body. Ayurvedic churnas combine all six of the ayurvedic tastes: sweet, sour, salty, pungent, bitter, and astringent. They are created through the combination of a number of different fresh herbs, and can be added to almost any foodstuff. Not only do churnas improve the taste of the dish and add their own nutritional kick, they also bring out the medicinal qualities of the foods they are added to. Churna is an ayurvedic poly herbal formulation used for its anti-ulcer, anti-diabetic, wound-healing, antioxidant, immuno modulatory and rejuvenating purpose. In this review article It includes five herbal drugs, ie; dried whole plant part of [1]Mimosa pudica (Family: Leguminosae), dried rind of Punica granatum(Family: Lythraceae),dried fruit of Emblica officinalis (familuy: Ephorbiaceae), dried seeds of [2]Sesamum indicum (family: Pedaliaceae), dried seeds of Cuminum cyminum(family: Apiaceae) in powder form.The present review encompasses all the important aspects of polyherbal formulation-churna of above mentioned four plants. Source

Sathya V.,Prist University | Balasubramaniyam K.,Egspillay Engineering College | Murali N.,Egspillay Engineering College | Rajakumaran M.,Egspillay Engineering College | Vigneswari,Kings College
IEEE-International Conference on Advances in Engineering, Science and Management, ICAESM-2012

Steganography means hiding a message. Information hiding technique is a new kind of secret communication technology. Information hiding system uses multimedia objects like audio, images and text. Digital audio, images, text are increasingly furnished with distinguishing but imperceptible marks, which may contain a hidden copyright notice or serial number or even help to prevent unauthorized copying directly. Today the growth in the information technology, especially in computer networks such as internet, mobile communication and digital multimedia applications such as digital camera, handset video etc., © 2012 Pillay Engineering College. Source

Bhimanadhuni C.N.,Prist University | Bhimanadhuni C.N.,Annabattuni Satya Narayana Pharmacy College
Der Pharma Chemica

A simple and reliable head space Gas chromatographic method was developed for the determination of methanol, Diethyl Ether, Isopropyl alcohol and Toluene as residual solvents present in Mirabegron. The proposed method is based on flame ionization detection technique with DB-624 (60m × 0.53 × 3μm) as stationary phase. The carrier gas flow was at 41.4 kPa using pressure mode and the sample was introduced with slit ratio 1:10 The capillary injector temperature set at 220°c and FID-detector set at 240°c. The column temperature was 50°c for 5min, further the temperature ramp set at 15°c /min to attain 230°c, and then hold for 3min, the chromatograph stop time was set to 20min. The concentration ranges between 15-90μg/ml for methanol, 25-150μg/ml for Diethyl Ether, 25-150μg/ml for isopropyl alcohol and 4.45-26.7μg/ml for toluene respectively. The propose method was validated as per the ICH guidelines. The method was accurate, precise, and rapid found to be suitable for the quantitative analysis of the residual solvents present in Mirabegron. Source

Muruga Lal Jeyan J.V.,Alagappa Chettiar College of Engineering And Technology | Senthil Kumar M.,Prist University
International Review of Mechanical Engineering

A multi-hole conical probe is employed to determine the velocity of the air flow, total and static pressures of the wind tunnel, wave angle in addition to estimating the noise of the test segment. It twinkles with the unique qualities of being trouble-free, vigorous with the flexibility to be applied even in ruthless situations. Our innovative conical wedge type probe is launched by means of AUTOCAD and engineered by exploiting the stain less steel material. The pressure holes are situated at the end of the conical probe which is applied to calculate the pressure and flow velocity of the atmosphere. The novel probe is performed at supersonic settings by the effective use of the proficient Computational Fluid Dynamic Analysis (CFD analysis) software. It discharges the task of assessing the enduring competence of the projected probe under a variety of situations like fixed pressure and temperature along with the velocity of the air flow at different machnumbers. This sample fashioned blueprint built up in CFD is estimated under supersonic backdrops up to mach 3. Thus, it is crystal clear that that our well-conceived sample developed with semi nose angle 20° ushers in a sterling performance in mach 2.8 triggering an incredible shock wave of 29.3°. © 2014 Praise Worthy Prize S.r.l. - All rights reserved. Source

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