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Sarojini S.,PRIST University | Manavalan R.,Annamalai University
International Journal of Drug Development and Research | Year: 2012

Over the past four decades, gastro retentive dosage forms have recently become a leading methodology in the field of site-specific orally administered controlled release drug delivery system. Gastroretentive dosage forms have the potential to improve local therapy with an increase of short gastric residence time and unpredictable gastric emptying time and decrease the variation in bioavailability which is unobserved, in other commercially available preparations. With the advent to current scientific and patented literature, this review have covered in detail the recent developments of FDDS including the physiological and formulation variables affecting gastric retention, classification, approaches to design single and multiple unit floating systems, formulation aspects and invitro and invivo studies to evaluate the performance. © 2010 IJDDR.

Raja A.,Jamal Mohammed College | Prabakarana P.,PRIST University
American Journal of Drug Discovery and Development | Year: 2011

This review summarizes shortly about bioactive metabolites produced by actinomycetes group. The Actinomycetes get their name from the fact that some of them form branching filaments that look kind of like the branching hyphae (collectively referred to as a mycelium) formed by fungi. In an effort to lessen confusion, Actinomycetes are now commonly referred to as Actinobacteria. Actinobacteria are neat because they tend to produce cool secondary metabolites, many of which have been successfully isolated and turned into useful drugs and other organic chemicals. In particular, an appreciable number of Actinobacteria produce antibiotics, which they use to compete with fungi and other bacteria for resources (and because they are totally badass). The genus Streptomyces (not to be confused with Streptococcus!) is a particularly fruitful source of these compounds, a number of which have been developed as antifungals, antibiotics (antibacterials) and chemotherapeutic (anticancer) drugs. Actinomycetes, mainly Streptomyces species, produce tetracyclines, aminoglycosides (streptomycin and its relatives), macrolides (erythromycin and its relatives), chloramphenicol, ivermectin, rifamycins and most other clinically useful antibiotics that are not beta-lactams. Actinomycetes are the most predominantly used in antibiotic production technology. © 2011 Academic Journals Inc.

Majumder P.,PRIST University | Paridhavi M.,Rajiv Gandhi Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

More number of different biologically active and therapeutic potential phytochemicals are drown from plant kingdom. The utilization of those natural substances for human aliments as well as animals begins from time immortal. Till date almost 3000 different medicinal plants in Indian sub continent has found to great potential in the emerging field of herbal medicines. More specific information about plant source as medicine had been mentioned in our old golden heritagious ayurvedic literatures and also other alternate system of medicine. Numerous number of phyto compounds were characterized from plants which are now using in modern herbal pharmacy for the treatment of many diseases. Well authenticated medical plants may play an important role in the management of different clinical problems especially in developing countries. The present paper reveals the literature up to date review on ethno-phyto medicinal research outcome and uses with pharmacological screening of every plant part of this three medicinal plants, i.e Cassia Auriculata Linn, Cinnamomum tamala, Ficus benghalensis used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy in various reported herbal formulations. The name and parts of the plant studied, the spectrum of activity, and methods used are discussed in this review paper.

Upgade A.,PRIST University | Prabakaran P.,Marudupandiyar College
Journal of Pharmaceutical Sciences and Research | Year: 2015

Multidrug resistance in India is direct threat to developing medical technology and sciences. Disease management is somehow tedious task for physicians. Urinary tract infection is one among them; improper diagnosis, unclear symptoms, and resistance due to indiscriminate use of antibiotics are the major reasons. This study designed to develop a combinational therapy of nanotechnology and plant metabolites together for better alternative to traditional medicines. Silver nanoparticles were synthesized using leaves of Carica papaya. Synthesized silver nanoparticles were then subjected to check antibacterial activity against clinical isolates i.e. uropathogens like P. aeruginosa, Klebsiella pneumoniae and E.coli with methanolic plant extract of leaves of Carica papaya. Traditional testing were performed with characterization of silver nanoparticles and results shows it can be prove as a promising therapy in future. As compare to traditional antibiotics herbal drug with nanoparticles have more effective bacteriostatic activity. © 2009 PharmaInfo Publications. All rights reserved.

Punitha S.,PRIST University | Girish Y.,PRIST University
International Journal of Research in Pharmaceutical Sciences | Year: 2010

Mucoadhesion is defined as the ability of material adheres to biological tissue for an extended period of time. Over the last few decades' pharmaceutical scientists throughout the world are trying to explore transdermal and transmucosal routes as an alternative to injections. Among the various transmucosal sites available, mucosa of the buccal cavity was found to be the most convenient and easily accessible site for the delivery of therapeutic agents for both local and systemic delivery as retentive dosage forms. Buccal delivery of the desired drug using mucoad-hesive polymers has been the subject of interest since the early 1980s. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. The mucoadhesive interaction is explained in relation to the structural characteristics of mucosal tissues and the theories & properties of the polymers. The success and degree of mucoadhesion bonding is influenced by various polymer-based properties. Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer net-works to more specific second-generation systems based on lectin, Thiol and various other adhesive functional groups. This paper aims to review the mucoadhesive polymeric platforms, properties & characteristics to provide basics to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design. © Pharmascope Foundation.

Bhaskar A.,PRIST University | Samant L.R.,PRIST University
Global Journal of Pharmacology | Year: 2012

An ethno botanical survey was carried out among the Malayali tribes in Pachamalai Hills, Trichy district, Tamil Nadu. The investigation revealed that, the traditional healers used 66 species of plants distributed in 64 genera and 42 families were used to treat various diseases. The documented medicinal plants were used to cure different ailments such as skin problems, cold, fever, cough, headache, diarrhoea, fertility problems, toothache, stomach ache, wounds, diabetes, rheumatism, asthma, dysentery, small pox, bone fractures, ear ache, hair loss and poison (snake, scorpion and insect) bites etc. This study showed that the Malayali tribes still continue to depend on medicinal plants, however the traditional healers are on the decline because the younger members of the tribe have no interest and knowledge of this form of medicine as they have started moving towards the towns and cities. Therefore it is necessary to document the plants to effectively conserve them. © IDOSI Publications, 2012.

Elangovan K.,PRIST University
International Conference on Pattern Recognition, Informatics and Medical Engineering, PRIME 2012 | Year: 2012

Orthogonal Frequency Division Multiplexing (OFDM) has recently been applied in wireless communication systems due to its high data rate transmission capability with high bandwidth efficiency and its robustness to multi-path delay. Fading is the one of the major aspect which is considered in the receiver. To cancel the effect of fading, channel estimation and equalization procedure must be done at the receiver before data demodulation. In this paper dealt the comparisons of various algorithms, complexity and advantages, on the capacity enhancement for OFDM systems channel estimation techniques. Mainly three prediction algorithms are used in the equalizer to estimate the channel responses namely, Least Mean Square (LMS), Normalized Least Mean Square (NLMS) and Recursive Least Square (RLS) algorithms. These three algorithms are considered in this work and performances are statically compared by using MATLAB Software. © 2012 IEEE.

Selvamangai G.,Alpha Arts and Science College | Bhaskar A.,PRIST University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To characterize the phytochemical constituents of Eupatorium triplinerve using GC -MS. Methods: Ten grams of the powdered sample was subjected to column chromatography over silica gel (100-200 mesh) and eluted with n-hexane, chloroform, ethanol and methanol respectively. n-Hexane and Chloroform did not elute much of the compounds. The methanol fraction of the Eupharbatum triplinerve was taken for GC-MS analysis. The analysis was carried out on a GC Clarus 500 GC system with a column packed with Elite - 1 (10% dimethyl poly siloxane, 30 × 0.25 mm ID × 1 EM df), the compounds are separated using with Helium as carrier gas at a constant flow 1ml/min. sample extract (2 μL) injected into the instrument was detected by Turbo gold mass detector (Perkin Elmer) with the aid of the Turbo mass 5.1 software. Results: The GC MS analysis provided peaks of eleven different phytochemical compounds namely hexadecanoic acid (14.65%), 2,6,10-trimethyl,14-ethylene-14-pentadecne (9.84%), Bicyclo[4.1.0]heptane, 7-butyl-(2.38%), Decanoic acid, 8-methyl-, methyl ester (3.86%), 1-undecanol (7.82%), 1-hexyl-1-nitrocyclohexane (2.09%), 1,14-tetradecanediol (6.78%), Octadecanoic acid, 2-hydroxy-1,3-propanediyl ester (19.18%) and 2-hydroxy-3-[(9E)-9-octadecenoyloxy] propyl(9E)-9-octadecenoate (8.79%). Conclusions: The bioactive compounds in the methanolic extract of Eupatorium triplinerve have been screened using this analysis. Isolation of individual components would however, help to find new drugs. © 2012 Asian Pacific Tropical Biomedical Magazine.

Talluri S.,South Dakota School of Mines and Technology | Raj S.M.,South Dakota School of Mines and Technology | Raj S.M.,PRIST University | Christopher L.P.,South Dakota School of Mines and Technology
Bioresource Technology | Year: 2013

The abilities of the extreme thermophilic bacterium Caldicellulosiruptor saccharolyticus DSM 8903 to ferment switchgrass (SWG), microcrystalline cellulose (MCC) and glucose to hydrogen (H2) in one-step were examined. Hydrogen production from glucose reached the theoretical maximum for dark fermentation of 4mol H2/mol glucose. The H2 yield on MCC and SWG after 6days of fermentation was 23.2mmol H2/L or 9.4mmol H2/g MCC and 14.3mmol H2/L or 11.2mmol H2/g SWG, respectively. The rate of H2 formation however was higher on MCC (0.7mmol/Lh) than SWG (0.1mmol/Lh). C. saccharolyticus DSM 8903 was able to produce H2 directly from mechanically-comminuted SWG without any physicochemical or biological pretreatment. Combining four processing steps (pretreatment, enzyme production, saccharification and fermentation) into a single biorefinery operation makes C. saccharolyticus DSM 8903 a promising candidate for consolidated bioprocessing (CBP) of lignocellulosic biomass. © 2013 Elsevier Ltd.

RajaRajan A.,PRIST University
ICECT 2011 - 2011 3rd International Conference on Electronics Computer Technology | Year: 2011

This paper is regarding an XML based language to perform artificial neural network application (ANN). Here we see how Neural XML (NXML) can be used for an 'intelligent' task that is for identifying images based on various criteria with an example of interesting 'pseudo' brain disorder detection. This is the model in which artificial neural networks are based. Thus far, artificial neural networks haven't even come close to modeling the complexity of the brain, but they have shown to be good at problems which are easy for a human but difficult for a traditional computer, such as image recognition and predictions based on past knowledge. The algorithm which we use here is BPN. Back-propagation is well suited to pattern recognition problems. In this study we considered a perceptron based feed forward neural network for the detection of brain disorder. © 2011 IEEE.

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