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Krupatkin A.I.,Priorov Central Research Institute of Traumatology and Orthopedics
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Information aspects of tissue microcirculation were investigated in 64 patients with complex regional pain syndrome after sympathectomy using a wavelet-analysis of skin microvascular blood flow oscillations. The early reorganization of information in the trophotropic direction at the level of microvascular tissue systems, its predomination and conservation along the microvascular networks facilitate the optimal realization of adaptive reactions and, as a result, lead to the best treatment efficacy. In these cases, the complete elimination of disease and achievement of excellent treatment results are possible. The best treatment efficacy could not be reached without the above-mentioned information changes. On the contrary, the predomination and conservation of ergotropic information in the early stages after surgery predicted worse outcomes of sympathectomy. Tissue desympathisation is not required for the formation of trophotropic purposefulness of information in microvascular networks; it is enough to achieve a certain threshold to decrease the sympathetic activity. Source


Krupatkin A.I.,Priorov Central Research Institute of Traumatology and Orthopedics
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Objectives. To study the involvement of sensory peptidergic fibers in the posttraumatic regional pain syndrome (RPS). Material and methods. We examined 57 patients with distal radial bone fractures (27 with noncomplicated fractures and 30 with the development of posttraumatic RPS) using computed thermography and laser Doppler flowmetry (LDF) with wavelet-analysis of skin blood flow oscillations. Results. It has been shown that neurogenic inflammation, along with sensory peptidergic fibers activation, is an early component of posttraumatic RPS. Thermographic and LDF criteria for early diagnosis of posttraumatic RPS during the 1st month after the injury are singled out. Conclusion. The microvascular blood flow oscillatory structures, reflected sensory peptidergic activation and inflammatory sympatholysis are the most effective diagnostic signs (diagnostic effectiveness is 91.2%). Source


Krupatkin A.I.,Priorov Central Research Institute of Traumatology and Orthopedics
Human Physiology | Year: 2010

Laser Doppler flowmetry with wavelet analysis of oscillations of the blood flow in the glabrous skin of the second and fifth fingertips of 30 healthy individuals and 57 patients before and after median and ulnar nerve sutures (n = 29) and after hand sympathectomy (n = 28). Information processes in microvascular networks include both the stationary and oscillatory components. This study is the first to apply wavelet analysis of the blood flow oscillatory organization to studying the dynamics of information processes in microcirculatory networks. A methodological approach was proposed to estimate the total quantity of information, the value and semantic features of different information channels and the information regime (multichannel or resonance) in microcirculatory networks. The deficit of both general information and its content (particularly, of external information), a decrease in the accessibility to the information and the system of self-organization were typical during the denervation syndrome. The semantic information signs changes mainly after sympathectomy. The dynamics of the information process reflects the functional significance of microcirculation in the course of nerve regeneration and skin reinnervation. The increment in information quantity with trophic content occurred at the preimpulse stage of nerve regeneration; it corresponds to the quantitative development of skin microvascular networks for trophic support of reinnervation. The semantic information content was predominantly modulated at the impulse stage due to the increase in homeostatic control intensity. Information peculiarities in the transitional period (from the preimpulse to impulse stage) included a decrease in sporadic processes, an increase in determinism in the system control, the predomination of the trophic content assimilation with the increment in the myogenic activity proper, and the possibility of both multichannel and resonance regimes. The general biological law of the antientropic importance of information for decreasing stochastic processes and the system control support has been confirmed. © A.I. Krupatkin, 2010. Source


Krupatkin A.I.,Priorov Central Research Institute of Traumatology and Orthopedics
Human Physiology | Year: 2010

The key role of information processes for ensuring the optimal sanogenesis in humans was shown by the wavelet-analysis of skin microvascular blood flow oscillations in 64 patients with complex regional pain syndrome after sympathectomy. The early reorganization of information in the trophotropic direction at the level of microvascular tissue systems, and its predominance and preservation along the microvascular networks facilitate optimal adaptive reactions and, as a result, are conducive to maximum treatment efficiency. In these cases, the complete elimination of disease and the achievement of excellent treatment results are possible. The maximum treatment efficiency could not be reached without the above-mentioned informational changes. On the contrary, the predominance and preservation of ergotropic information in the early periods after surgery were unfavorable for the prediction of the clinical outcome of sympathectomy. Tissue sympathectomy is not required for the formation of the trophotropic type of information exchange in microvascular networks; it is enough to achieve a certain threshold of a sympathetic activity decrease. The results obtained may be useful for investigating the physiological mechanisms of informational treatment technologies (homeopathy etc.). © 2010 Pleiades Publishing, Ltd. Source


Krupatkin A.I.,Priorov Central Research Institute of Traumatology and Orthopedics
Human Physiology | Year: 2012

The first objective diagnosis of sympathetically maintained forms of pain employing laser Doppler flowmetry (LDF) and specifically targeted at detecting sensory-sympathetic coupling in the skin has been developed and tested in 49 patients with the posttraumatic complex regional pain syndrome. Sensory-sympathetic coupling was diagnosed as a combination of sympathetic vasomotor activity and the presence of sensory peptidergic blood flow oscillations in a frequency band of 0.047-0.069 Hz in the LDF wavelet spectrum. The results of the LDF diagnosis were compared with the clinical evaluation of sympathetically maintained pain carried out after desympathization surgery (thoracoscopic clipping above and below the Th3 ganglion of the sympathetic chain in 33 patients and perivascular sympathectomy at the level of the brachial vascular bundle in 16 patients). The sensitivity of preoperative LDF diagnosis was 90.2%; the specificity was 87.5%; the positive predictive value was 97.3%; the negative predictive value was 63.6%; and the diagnostic efficiency was 89.8%. © 2012 Pleiades Publishing, Ltd. Source

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