Princess Nourah Bint Abdul Rahman University

Riyadh, Saudi Arabia

Princess Nourah Bint Abdul Rahman University

Riyadh, Saudi Arabia
SEARCH FILTERS
Time filter
Source Type

Alturiqi A.S.,Princess Nourah Bint Abdul Rahman University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2016

A novel betaxolol ion-selective electrode is prepared, characterized, and used in biological fluids analysis. The electrode incorporates PVC membrane with betaxolol-tetraphenylborate (BT-TPB) ion pair complex with di-butyl phosphate (DBP) as a plasticizer. The calibration curve is linear in the range from 1.0×10−6 to 1.0×10−2 mol/L with a correlation coefficient of 0.997 and slope of 59.0 mV/decade, which is close to the Nernstian slope. Selectivity coefficients of BT related to a number of interfering cation, sugars and amino-acids were investigated. The influence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.20-8.30. The electrode was successfully used for potentiometric determination of betaxolol hydrochloride both in pure solutions and in biological fluids. © 2016, Global Research Online. All rights reserved.


Alturiqi A.S.,Princess Nourah Bint Abdul Rahman University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2016

The construction and electrochemical response characteristics of a poly vinyl chloride (PVC) membrane selective electrode for the determination of desvenlafaxine HCl (DVN) are described. The electrode incorporates PVC membrane with desvenlafaxine-silicomolybdate (DVN-SMA) ion pair complex with dioctylphthalate (DOP) as a plasticizer. The influence of the electrode composition, conditioning time of the electrode and pH of the test solution, on the electrode performance were investigated. The drug electrode showed Nernstian response in the concentration range from 1.0 × 10-5 M to 1.0 × 10-2 M with slope of 58.0 mV decade-1, and was found to be very precise and usable within the pH range 4 –8.5. The electrode showed good selectivity towards DVN with respect to some inorganic and organic compounds. The electrode was successfully used for potentiometric determination of DVN both in pure solutions, urine and in pharmaceutical preparations. © 2016, Global Research Online. All rights reserved.


Al-Bedair L.A.,Princess Nourah Bint Abdul Rahman University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2016

A coated-wire ion selective electrode based on ion-pair complex of venlafaxine (VEN) with phosphomolybdic acid (PMA) as electroactive material in the presence of dioctylphthalate (DOP) as the plasticizing solvent mediator was prepared. The electrode showed a fast, stable and Nernstian response over a wide venlafaxine concentration range (1.0×10-5 to 1.0×10-2 mol L-1) with a slope of 58.70 mV dec-1 of concentration. The influences of membrane composition, temperature, pH of the test solution, and foreign ions on the electrode performance were investigated. The electrode was suitable for use in aqueous solutions in a wide pH range of 4.0 to 8.0. The standard electrode potentials, E°, were determined at different temperatures and used to calculate the isothermal temperature coefficient (dE°/dT) of the electrode. The proposed sensor displayed useful analytical characteristics for the determination of VEN in pure solutions and in biological fluids such as plasma and urine samples using the standard additions method. © 2016, Global Research Online. All rights reserved.


Al-Qahtani S.D.,Princess Nourah Bint Abdul Rahman University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2016

Amineptine hydrochloride (AMP) coated wire graphite electrode based on amineptine-phosphotungstate (AMP-PT) as electroactive material in the presence of dibutyl phthalate DBP as the plasticizing solvent mediator has been described. The sensor exhibited a linear response with a good Nernstian slope over a relatively wide range of concentration. The sensor displays Nernstian response of 58.7 mV/decade over the concentration range of 1.0×10-5 to 1.0×10-2 M. The potentiometric measurements can be done in the pH range of 2.0 to 4.0. The measurement interferences in the presence of inorganic cations and organic substances were studied using matched potential method for selectivity coefficient determination. Application of this potentiometric sensor for the amineptine determination in pure form and urine was satisfactory results. © 2016, Global Research Online. All rights reserved.


Aljazzar S.O.,Princess Nourah Bint Abdul Rahman University
International Journal of Pharmaceutical Sciences Review and Research | Year: 2016

A potentiometric titration technique has been used to determine the stability constants for the various complexes of Cu(II) with drug fluoxetine hydrochloride (FLX) as primary ligand and glycine oligopeptides (L) as secondary ligands. The formation constants of the complexes formed in aqueous solutions and their concentration distributions as a function of pH were evaluated at 25°C and ionic strength 0.1 M NaClO4. The relative stabilities of the ternary and corresponding binary complexes were also studied. © 2016, Global Research Online. All rights reserved.


Al-Gebaly A.S.,Princess Nourah bint Abdul Rahman University
Pakistan Journal of Biological Sciences | Year: 2017

Background and Objective: Cadmium (Cd) is a non-essential metal whose dispersion in the environment has increased recently, Cd may enhance cell oxidative stress that leads to DNA damage and apoptotic cell death. The study aimed to evaluate the antioxidative capability of Burdock root ‘Arctium lappa’ on cadmium-induced oxidative stress and histopathology of the kidney of Wistar rats. Methodology: Cadmium was applied in a form of cadmium chloride to three groups (15 mg Cd kg-1) for five weeks with two groups pre-treated with ‘Arctium lappa’ administration, 100 and 200 mg kg-1 b.wt. Data were analyzed using one way analysis of variance (ANOVA) followed by Least Significant Difference (LSD) test to determine the difference among means using the JMP version 12. Results: Results revealed that cadmium induced a significant disorganization (p<0.05) of renal structure with collapsed tubular lamina and 76 µm tail length of the cells was observed, while histological sections of kidney pre-treated with 100 mg Arctium lappa kg-1 b.wt., showed a slightly less hypercellularity of glomerulus and reduction in the cell tail (59 µm). Furthermore, histological sections of kidney of rats pre-treated with 200 mg Arctium lappa kg-1 b.wt., showed high improvement of renal tubules and glomerulus with a prominent urinary space beside tail length of cells was recorded as 39 µm which was lower in comparison to other groups. Conclusion: Moreover, cadmium induced cellular destruction of the kidney was resumed with the pre-treatment of the secondary metabolites as an antioxidant compounds that produced from plant extracts. Arctium lappa leaf extract was efficient at both applied doses while 200 mg Arctium lappa kg-1 b.wt., had the most ameliorative effect. © 2017 Asma Suliman AL-Gebaly.


Ammar R.A.,Princess Nourah bint Abdul Rahman University | Al-Qahtani S.D.,Princess Nourah bint Abdul Rahman University
Journal of Solution Chemistry | Year: 2017

The complex formation equilibria of [Pd(FLX)(H2O)2]2+, where FLX = the drug fluoxetine, with the bio-ligands (L), glycine, serine, cysteine, histidine, glycylglycine and glycylvaline, were studied and their formation constants were determined. Stoichiometries and stability constants of the complexes were determined at 25 °C and at constant 0.10 mol·dm−3 NaNO3 ionic strength. The concentration distribution of the complexes in solution was evaluated. Palladium(II) complexes were synthesized and characterized by the 1H NMR and electronic spectral studies. The structures consist of monomeric units in which the Pd(II) atoms exhibit square planar geometry. © 2017, Springer Science+Business Media New York.


Two simple, sensitive spectroscopic and atomic absorption spectrometric (AAS) methods have been suggested for the determination of doxazosinmesylate in pure form and tablet formulations. The methods are based on the formation of ion-pair associate between the drug and the inorganic complex, bismuth(III) tetraiodide. The reaction occurs in nitric acid medium forming orange-reda ion-pair associate which is instantaneously precipitated. The formed precipitate is filtered off and the residual unreacted metal complex in the filtrate is determined either spectrophotometrically at 453 nm or by AAS at 223.1 nm. Also, the precipitatemay be dissolved in acetone and quantified spectrophotometically at 470nm or decomposed by hydrochloric acid, and the bismuth content is determined by AAS at 223.1 nm. The two methods permit the determination of doxoazosinmesylate in the range of 5-80μg L-1. The proposed methods were successfully applied to determine doxazosinmesylate in its tablet formulations without any evidence for interference from pharmaceutical additives. The results were in good agreement with those obtained the reference method. The proposed methods, especially if automated, can be confidently applied for quality control and routine analysis of doxazosinmesylate.


Al-Megrin W.A.I.,Princess Nourah Bint Abdul Rahman University
Biosciences Biotechnology Research Asia | Year: 2016

To investigate the efficacy of pomegranate (Punica granatum) as an alternative and safe treatment against Hymenolipes nana through experimental study on the white laboratory mice. Twenty eight Swiss albino mice naturally infected with Hymenolipes nana. Animals were divided into four groups, one group as control and groups 2-4 were fed daily with dose 0.5 ml, 1.0 ml and 1.5 ml pomegranate peel extract (300 mg/kg) respectively, The egg counts per gram (EPG) one day before treatment and on day 1, 7, 14, and 21 after treatment. All animals were then sacrificed under on day 21. The content of intestines were examined for the presence of worms and counting. Results from current Study revealed that, pomegranate peel extract was lead to reduce the eggs output in fecalpellets of treated infected groups comparing with control group. In addition, the different doses 0.5 ml, 1.0 ml and 1.5 ml of a pomegranate peel extract demonstrated a directly proportional reduction in EPG count (31.5, 38.6 and 43.5) respectively. On the other hand, the number of worms at necropsy was decreased (15.6 ±2.6, 8.4 ±2.1 and 5.7±2.5) in treated infected groups (0.5 ml, 1.0 ml and 1.5 ml) respectively. The findings of this study indicate that Pomegranate peel extract has active role to treat infection of H. nana due to possesses potential anti-cestodal activity.


AL-Megrin W.A.I.,Princess Nourah Bint Abdul Rahman University
Pakistan Journal of Biological Sciences | Year: 2015

Cryptosporidium parasite has gained an attention as an emerging pathogen in the last few decades. It is a zoonotic and is transmitted via the fecal-oral route; this has been implicated as one of the more important opportunistic infections in patients with Acquired immune deficiency syndrome. The results showed the presence of Cryptosporidium oocyst in fecal of sheep (11.1 and 22.2%), goats (15.5 and 10.3%) and camels (18.4 and 22.4%) by using microscopic Ziehl-Neelsen and a serological Enzyme-linked immunosorbent assay, respectively. Since there is no a gold standard technique for detection of Cryptosporidium oocysts; this study aimed to compare the efficacy of microscopic tests in the detection of oocysts in feces with ELISA assay. Results showed that positive samples (22.4 and 22.2%) were detected by ELISA in camels and sheep respectively. Contrary, Ziehl-Neelsen exceeded ELISA in the detection of oocysts in goats samples (15.5 and 10.3%) in goats. Statistical analysis clarified a significant correlation between Ziehl-Neelsen and ELISA for the detection of Cryptosporidium oocysts. © 2015 Asian Network for Scientific Information.

Loading Princess Nourah Bint Abdul Rahman University collaborators
Loading Princess Nourah Bint Abdul Rahman University collaborators