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Alturiqi A.S.,Princess Nourah Bint Abdul Rahman University | Aljazzar S.O.,Princess Nourah Bint Abdul Rahman University | Ammar R.A.,Princess Nourah Bint Abdul Rahman University | Khalaf N.,King Saud University
Oriental Journal of Chemistry | Year: 2017

A coated-wire ion selective electrode based on ion-pair complex of citapolarm hydrobromide (CT) with sodium tetraphenyl borate as electroactive material in the presence of dioctylphthalate (DOP) as the plasticizing solvent mediator was prepared. The electrode displays Nernstian response of 56.83 mV/decade over the concentration range of 1.0×10-6 to 1.0×10-2 mol/L at 25°C. The influence of membrane composition, pH of the test solution and foreign ions on the electrode were investigated. The electrode was successfully applied to determination of the drug in pure form, urine and plasma by standard addition potentiometry. © 2017, Oriental Scientific Publishing Company. All rights reserved.


Al-Otaibi J.S.,Princess Nora Bint Abdulrahman University | Al-Otaibi J.S.,Princess Nourah Bint Abdul Rahman University | Teesdale Spittle P.,Victoria University of Wellington | El Gogary T.M.,Jazan University | El Gogary T.M.,Damietta University
Journal of Molecular Structure | Year: 2017

Anthraquinones form the basis of several anticancer drugs. Anthraquinones anticancer drugs carry out their cytotoxic activities through their interaction with DNA, and inhibition of topoisomerase II activity. Anthraquinones (AQ4 and AQ4H) were synthesized and studied along with 1,4-DAAQ by computational and experimental tools. The purpose of this study is to shade more light on mechanism of interaction between anthraquinone DNA affinic agents and different types of DNA. This study will lead to gain of information useful for drug design and development. Molecular structures were optimized using DFT B3LYP/6-31 + G(d). Depending on intramolecular hydrogen bonding interactions two conformers of AQ4 were detected and computed as 25.667 kcal/mol apart. Molecular reactivity of the anthraquinone compounds was explored using global and condensed descriptors (electrophilicity and Fukui functions). Molecular docking studies for the inhibition of CDK2 and DNA binding were carried out to explore the anti cancer potency of these drugs. NMR and UV-VIS electronic absorption spectra of anthraquinones/DNA were investigated at the physiological pH. The interaction of the three anthraquinones (AQ4, AQ4H and 1,4-DAAQ) were studied with three DNA (calf thymus DNA, (Poly[dA].Poly[dT]) and (Poly[dG].Poly[dC]). NMR study shows a qualitative pattern of drug/DNA interaction in terms of band shift and broadening. UV-VIS electronic absorption spectra were employed to measure the affinity constants of drug/DNA binding using Scatchard analysis. © 2016 Elsevier B.V.


Al Mugren K.S.,Princess Nourah Bint Abdul Rahman University | El Sayed Y.,King Khalid University | Shoukry H.,King Khalid University | El Taher A.,Qassim University
Digest Journal of Nanomaterials and Biostructures | Year: 2016

Phosphate glasses with compositions (70-x) P2O5- 30ZnO- xCuO (where x= 10, 15 and 20 in mol%) have been prepared by melt-quenching Procedure. Effect of CuO percentage on the density of prepared samples has been studied. It was found that density decreases from 2.923 to 2.653 gm.cm-3 when CuO increases from 10 to 20 mol%. The values of molar volume (Vm), oxygen packing density (O. P. d), oxygen molar volume (VO), optical energy gap (Eopt) and glass transition temperature (Tg) of prepared glasses ware estimated. Moreover the UV-Vis-NIR spectroscopic study has been done and the optical properties of the prepared glasses were estimated. The optical band gap energy (Eopt) has been calculated, it was observed that Eopt increases from 3.33 eV to 3.43 eV with increasing CuO content from 10 to 20 mol%. Herein the glass system 60 P2O5- 30ZnO- 10CuO has two cut off wavelengths firstly at 420 nm and secondly at 1665 nm while the glasses modified by 15 and 20 mol% of CuO have only one cutoff wavelength in NIR region. The prepared glasses have transmission broad band from 1665 to 2940 nm. The structure of this glasses investigated by using Raman spectra. The optical properties results indicated that the prepared glasses are promising for optical filter applications in visible, NIR and IR region. © 2016, Inst Materials Physics. All rights reserved.


Al-Saeedi S.I.,Princess Nourah Bint Abdul Rahman University | Ammar R.A.,Princess Nourah Bint Abdul Rahman University | Alaghaz A.-N.M.A.,Jazan University
Oriental Journal of Chemistry | Year: 2016

Equilibrium studies have been carried out on complex formation of Co(II), with Girard T (GT) and L = amino acids in aqueous solution, at 25°C and ionic strength of I = 0.1M (NaNO3). The ternary complexes of Co(II) are formed by stepwise mechanism. The concentration distribution of the complexes is evaluated. © 2016, Oriental Scientific Publishing Company. All rights reserved.


Al-Saeedi S.I.,Princess Nourah Bint Abdul Rahman University | Alaghaz A.-N.M.A.,Princess Nourah Bint Abdul Rahman University | Alaghaz A.-N.M.A.,Jazan University | Ammar R.A.,Princess Nourah Bint Abdul Rahman University
Journal of Molecular Structure | Year: 2016

Complexes of cobalt(II), nickel(II), copper(II) and zinc(II) of general composition [M(L)2] have been. The elemental analyses, molar conductance, spectral, magnetic moment and thermal measurements studies of the compounds led to the conclusion that the ligand acts as a tridentate manner (OON). The molar conductance of the metal complexes in fresh solution of DMSO lies in the range of 8.10-10.18 Ω-1 cm2 mol-1 indicating their non-electrolytic behavior. On the basis of analytical and spectroscopic techniques, octahedral geometry of the complexes was proposed. The ligand field parameters were calculated for Co(II), Ni(II) and Cu(II) complexes and their values were found in the range reported for a octahedral structure. The data show that the complexes have composition of ML2 type. The activation of thermodynamic parameters are calculated using different equations. The octahedral geometry of the complexes is confirmed using DFT method from DMOL3 calculations and ligand field parameters. The cyclic voltammograms of the Cu(II)/Co(II)/Ni(II) complexes investigated in DMSO solution exhibit metal centered electroactivity in the potential range -1.5 to +1.5 V. The electrochemical data obtained for Cu(II) complexes explains the change of structural arrangement of the ligand around Cu(II) ions. © 2016 Elsevier B.V. All rights reserved.


PubMed | Institute of Clinical Pharmacodynamics, University of Florida, Princess Nourah Bint Abdul Rahman University and ICU Clinical Pharmacy Services
Type: Journal Article | Journal: Clinical pharmacology in drug development | Year: 2016

The aim of this study was to evaluate whether genetic polymorphisms in CYP3A5 and ABCB1 are responsible for the interindividual variability observed in quetiapine pharmacokinetics. Pharmacokinetic data from a randomized crossover study evaluating 2 quetiapine 25mg immediate-release tablets after single oral dose were used to develop a population pharmacokinetic model. The single nucleotide polymorphisms (SNPs) evaluated for the genotype effects of quetiapine pharmacokinetics were CYP3A5 A6986G and ABCB1 C3435T, along with other demographic variables and formulations. A one-compartment distribution model with linear elimination plus four transit compartments for the delayed absorption adequately described quetiapine disposition. CYP3A5 *1/*1 individuals (n=3) had 29% increased clearance compared to *1/*3 and *3/*3 individuals. The impact of an increased clearance was evaluated by simulations. By computing the probability of target attainment (PTA) of steady-state therapeutic goal at 1-hour and 12-hour time points after 50-400mg twice-daily regimens, the results indicated that CYP3A5 genotype has minimal impact on the PTA of the 1-hour concentrations but a significant impact on the 12-hour concentrations. The interpretation based on the simulations does not call for a genotype-based dosing scheme and is consistent with consensus guidelines for quetiapine that therapeutic drug monitoring is considered useful. Clinical Pharmacology in Drug Development.


Khan M.,King Saud University | Al-Saleem M.S.M.,Princess Nourah Bint Abdul Rahman University | Alkhathlan H.Z.,King Saud University
Journal of Saudi Chemical Society | Year: 2016

The chemical composition of the essential oils of Plectranthus cylindraceus and Plectranthus arabicus grown in Saudi Arabia were analyzed using gas chromatography techniques (GC-MS, GC-FID, Co-GC, LRI determination, and database and literature searches) using two different stationary phase columns (polar and nonpolar). The analysis led to the characterization of a total of 157 different compounds from both oils. In the oil derived from P. cylindraceus, 79 compounds were identified, whereas 132 compounds were identified in the oil derived from P. arabicus; these compounds account for 95.2% and 98.4% of the total oil compositions, respectively. The major constituents of P. cylindraceus oil were patchouli alcohol (55.5. ±. 0.01%), 1,8-cineole (6.0. ±. 0.01%) and valerianol (3.8. ±. 0.18%), whereas, the main compounds of the P. arabicus oil were 1,8-cineole (50.5. ±. 1.37%), β-pinene (7.0. ±. 0.08%), camphor (6.3. ±. 0.19%) and β-myrcene (4.1. ±. 0.10%). To the best of our knowledge, patchouli alcohol found in high concentration in the P. cylindraceus oil has never been reported from the genus Plectranthus. Moreover, this is the first phytochemical study of P. arabicus. © 2016 King Saud University.


Two simple, sensitive spectroscopic and atomic absorption spectrometric (AAS) methods have been suggested for the determination of doxazosinmesylate in pure form and tablet formulations. The methods are based on the formation of ion-pair associate between the drug and the inorganic complex, bismuth(III) tetraiodide. The reaction occurs in nitric acid medium forming orange-reda ion-pair associate which is instantaneously precipitated. The formed precipitate is filtered off and the residual unreacted metal complex in the filtrate is determined either spectrophotometrically at 453 nm or by AAS at 223.1 nm. Also, the precipitatemay be dissolved in acetone and quantified spectrophotometically at 470nm or decomposed by hydrochloric acid, and the bismuth content is determined by AAS at 223.1 nm. The two methods permit the determination of doxoazosinmesylate in the range of 5-80μg L-1. The proposed methods were successfully applied to determine doxazosinmesylate in its tablet formulations without any evidence for interference from pharmaceutical additives. The results were in good agreement with those obtained the reference method. The proposed methods, especially if automated, can be confidently applied for quality control and routine analysis of doxazosinmesylate.


Al-Megrin W.A.I.,Princess Nourah Bint Abdul Rahman University
Biosciences Biotechnology Research Asia | Year: 2016

To investigate the efficacy of pomegranate (Punica granatum) as an alternative and safe treatment against Hymenolipes nana through experimental study on the white laboratory mice. Twenty eight Swiss albino mice naturally infected with Hymenolipes nana. Animals were divided into four groups, one group as control and groups 2-4 were fed daily with dose 0.5 ml, 1.0 ml and 1.5 ml pomegranate peel extract (300 mg/kg) respectively, The egg counts per gram (EPG) one day before treatment and on day 1, 7, 14, and 21 after treatment. All animals were then sacrificed under on day 21. The content of intestines were examined for the presence of worms and counting. Results from current Study revealed that, pomegranate peel extract was lead to reduce the eggs output in fecalpellets of treated infected groups comparing with control group. In addition, the different doses 0.5 ml, 1.0 ml and 1.5 ml of a pomegranate peel extract demonstrated a directly proportional reduction in EPG count (31.5, 38.6 and 43.5) respectively. On the other hand, the number of worms at necropsy was decreased (15.6 ±2.6, 8.4 ±2.1 and 5.7±2.5) in treated infected groups (0.5 ml, 1.0 ml and 1.5 ml) respectively. The findings of this study indicate that Pomegranate peel extract has active role to treat infection of H. nana due to possesses potential anti-cestodal activity.


AL-Megrin W.A.I.,Princess Nourah Bint Abdul Rahman University
Pakistan Journal of Biological Sciences | Year: 2015

Cryptosporidium parasite has gained an attention as an emerging pathogen in the last few decades. It is a zoonotic and is transmitted via the fecal-oral route; this has been implicated as one of the more important opportunistic infections in patients with Acquired immune deficiency syndrome. The results showed the presence of Cryptosporidium oocyst in fecal of sheep (11.1 and 22.2%), goats (15.5 and 10.3%) and camels (18.4 and 22.4%) by using microscopic Ziehl-Neelsen and a serological Enzyme-linked immunosorbent assay, respectively. Since there is no a gold standard technique for detection of Cryptosporidium oocysts; this study aimed to compare the efficacy of microscopic tests in the detection of oocysts in feces with ELISA assay. Results showed that positive samples (22.4 and 22.2%) were detected by ELISA in camels and sheep respectively. Contrary, Ziehl-Neelsen exceeded ELISA in the detection of oocysts in goats samples (15.5 and 10.3%) in goats. Statistical analysis clarified a significant correlation between Ziehl-Neelsen and ELISA for the detection of Cryptosporidium oocysts. © 2015 Asian Network for Scientific Information.

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