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Hamza, Jordan

Al-Ani A.H.,Bahrain Specialist Hospital | Al Kela T.,Prince Hamza Hospital
Journal of the Bahrain Medical Society | Year: 2013

Background: Diabetes mellitus is a common metabolic disorder in non-tropical countries. Hand complications are very infrequent in comparison with foot complications. Tropical diabetic hand syndrome has been documented in tropical countries and it is suggested that it may occur in non-tropical countries, but is seldom recorded. Objectives: To document the presence, the causes and the mode of presentation of diabetic hand syndrome in non-tropical countries. Methods: In the period 1st of February 2009 to the 5th of March 2010 five cases of diabetic hand syndrome were studied in Al Basher teaching hospital, Amman, Jordan. On admission a detailed history and physical examination were undertaken. This included fasting blood sugar estimation, deep wound swabs and plain x-rays of the affected limbs. Results: Three of the patients were males and two were females. Their ages ranged from 55 to 74 years, with a mean of 64.5 years. The left hand was affected in three patients; while the right was affected in the other two. The clinical history of diabetes ranged from 10 to 15 years, with a mean of 11.75 years. Three patients presented with an ulcer, one with an abscess and the other presented with gangrene. The ring finger was affected in two patients, the middle finger in one, the palm in one and the dorsum of the hand in one patient. More than one microorganism was isolated from all the swab cultures; however, Staphylococcus aureus was the most common organism. Conclusion: Although it is very infrequent in non-tropical countries, diabetic hand syndrome is a devastating cause of morbidity and mortality particularly in negligent, senescent patients with poorly controlled and long standing diabetes.

Tayyem R.F.,University of Jordan | Bawadi H.A.,Qatar University | Shehadah I.,King Hussein Cancer Center | Agraib L.M.,Hashemite University | And 5 more authors.
Clinical Nutrition | Year: 2016

Background & aims: Dietary pattern and lifestyle have been reported to be important risk factors in the development of colorectal cancer (CRC). However, the mechanism of action of dietary factors in CRC disease is unclear. The aim of this study is the examination of several dietary choices and their potential association with the risk of developing CRC. Methods: Dietary data was collected from 220 subjects who were previously diagnosed with CRC, and 281 control subjects (matched by age, gender, occupation and marital status). The data was collected between January 2010 and December 2012, using interview-based questionnaires. Multivariate logistic regression was used to estimate the relationship between dietary choices and risk of developing colorectal cancer. Results: Factor analysis revealed three major dietary patterns. The first pattern we identified as the "Healthy Pattern", the second was identified as "High Sugar/High Tea Pattern" and the third as "Western Pattern". In the Healthy Pattern group we found a 10.54% variation in food intake, while the intake variation was 11.64% in the Western Pattern. After adjusting for confounding factors, the Western Pattern food choice was found to be significantly associated with an increased risk of developing CRC (OR = 1.88; 95% CI = 1.12-3.16). The results for the Healthy and High-Sugar/High Tea Patterns showed a decrease, but the statistic was not significant for the risk of CRC development. Conclusion: The Western Pattern of dietary choice was directly associated with CRC. The association between the dietary food choice in the Healthy and High-Sugar/High Tea Patterns and colorectal cancer needs further study in our Jordanian population. © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Tayyem R.F.,Hashemite University | Ahmad I.M.,University of Nebraska Medical Center | Shehadah L.,King Hussein Cancer Center | Bani-Hani K.,Hashemite University | And 2 more authors.
Pakistan Journal of Nutrition | Year: 2015

A case-control study was conducted to evaluate some parameters of antioxidant and nutritional status in patients with colorectal cancer (CRC) and healthy controls. The present study was based on 25 patients with diagnosed CRC, ranging in age from 35 to 76 years with the mean age of 51.3±11.3 years. There were healthy volunteers (age-and sex-matched) serving as the control subjects. We measured reduced glutathione (GSH, a marker of antioxidant response) in erythrocytes along with the examination of plasma antioxidants (vitamin E, A and beta-carotene) and vitamin D. The results showed that the levels of vitamin D and GSH in the blood of the patients with CRC were significantly lower than the control. However, there was no significant difference in the level of vitamin A and beta-carotene in the blood of the patients with CRC as compared to control group. Interestingly, our results showed a significant increase in the blood level of Vitamin E in patients with CRC as compared to control. Our results indicate significant role of oxidative- induced injury in the CRC carcinogenesis. The decreased concentrations of vitamin D and GSH in CRC cases as compared to controls could be used as predictors for having CRC. However, no association between vitamin A and beta-carotene and CRC was detected. Higher plasma concentration of vitamin E was noticed in CRC cases comparing to controls. © Asian Network for Scientific Information, 2015.

Tayyem R.F.,Hashemite University | Bawadi H.A.,Qatar University | Shehadah I.N.,King Hussein Cancer Center | Abu-Mweis S.S.,Hashemite University | And 5 more authors.
Nutrients | Year: 2015

Objective: Diet and lifestyle have been reported to be important risk factors for the development of colorectal cancer (CRC). However, the association between total energy and nutrient intake and the risk of developing CRC has not been clearly explained. The aim of our study is to examine the relationship between total energy intake and other nutrients and the development of CRC in the Jordanian population. Research Methods and Procedures: Dietary data was collected from 169 subjects who were previously diagnosed with CRC, and 248 control subjects (matched by age, gender, occupation and marital status). These control subjects were healthy and disease free. Data was collected between January 2010 and December 2012, using interview-based questionnaires. Logistic regression was used to evaluate the association between quartiles of total energy, macro- and micronutrient intakes with the risk of developing CRC in our study population. Results: Total energy intake was associated with a higher risk of developing CRC (OR = 2.60 for the highest versus lowest quartile of intake; 95% CI: 1.21–5.56, p-trend = 0.03). Intakes of protein (OR = 3.62, 95% CI: 1.63–8.05, p-trend = 0.002), carbohydrates (OR = 1.41, 95% CI: 0.67–2.99, p-trend = 0.043), and percentage of energy from fat (OR = 2.10, 95% CI: 0.38–11.70, p-trend = 0.009) significantly increased the risk for the development of CRC. Saturated fat, dietary cholesterol and sodium intake showed a significant association with the risk of developing CRC (OR = 5.23, 95% CI: 2.33–11.76; OR = 2.48, 95% CI: 1.18–5.21; and OR = 3.42, 95% CI: 1.59–7.38, respectively), while vitamin E and caffeine intake were indicative of a protective effect against the development of CRC, OR = 0.002 (95% CI: 0.0003–0.011) and 0.023 (95%CI: 0.008–0.067), respectively. Conclusion: Our results suggest an increased risk for the development of CRC in subjects with high dietary intake of energy, protein, saturated fat, cholesterol, and sodium, and diets high in vitamin E and caffeine were suggestive of a protective effect against the risk of developing CRC. Impact: This is the first study in Jordan to suggest that it may be possible to reduce CRC risk by adjusting the intake of some macro-and micronutrients. © 2015 by the authors; licensee MDPI, Basel, Switzerland.

Tayyem R.F.,Hashemite University | Shehadeh I.N.,KHCC | AbuMweis S.S.,Hashemite University | Bawadi H.A.,Jordan University of Science and Technology | And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC). Materials and Methods: Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female). Results: Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04). Conclusions: The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.

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