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Derby, United Kingdom

Murdoch A.P.,Queens University | Michou J.N.,Pride Veterinary Center
Veterinary Journal | Year: 2016

A prospective, randomised, blinded, case-controlled clinical study was designed using client-owned dogs undergoing unilateral pelvic limb orthopaedic surgery, to determine the effect on induced motor activity by electrical stimulation of the sciatic nerve distal to the site of local anaesthetic administration. Dogs were administered 0.5% bupivacaine either extradurally or via a femoral and transgluteal sciatic electrolocation-guided nerve block prior to pelvic limb surgery. Motor response to electrical stimulation of branches of the sciatic nerve was tested and the minimum current required to induce muscle twitch was recorded prior to bupivacaine administration. Provided sensory blockade had been deemed successful intraoperatively, testing was repeated postoperatively, with each dog acting as its own control. Paired t-tests were performed to compare pre- and postoperative minimum currents.Eleven dogs administered extradural and 11 dogs administered femoral and sciatic perineural bupivacaine were eligible for post-operative testing. All dogs displayed normal motor response to electrical stimulation of the sciatic nerve at both sites tested before and after bupivacaine administration. There was no significant difference in the minimum current required to induce muscle twitch between pre- and post-operative testing (P = 0.31 sciatic site, P = 0.36 peroneal site), nor between the two groups using different loco-regional anaesthetic techniques (minimum P = 0.13). This study shows that stimulation of the sciatic nerve distal to the site of bupivacaine administration induces motor activity, despite adequate sensory blockade. This is relevant in surgical cases where mechanical stimulation of the sciatic nerve might be expected and needs to be recognised to avoid postoperative neurapraxia. © 2015 Elsevier Ltd. Source


De Lima Dantas B.,University of Glasgow | De Lima Dantas B.,Pride Veterinary Center | Durand A.,University of Glasgow | Parkin T.,University of Glasgow | Broome C.,University of Glasgow
Veterinary and Comparative Orthopaedics and Traumatology | Year: 2016

Objectives: 1) To describe a radiographic method for determination of joint orientation lines and anatomical joint angles in orthogonal planes of feline radii; 2) to establish a range of normal radial joint orientation angles and anatomical axes in a feline population; and 3) to assess the repeatability and reliability of this methodology. Methods: The radial anatomical axis, elbow and carpal joint reference lines, and the intersecting angles of each: anatomical medial proximal (aMPRA) and lateral distal radial angles (aLDRA), anatomical caudal proximal (aCdPRA) and distal radial angles (aCdDRA), and sagittal procurvatum (SP) were determined on the orthogonal radiographs of 14 feline limbs. Intra- and inter-observer agreement was determined based on repeated independent readings by two observers using Bland-Altman plots. Results: The mean ± standard deviation (SD) and 95% confidence interval (CI) for the feline radii were: aMPRA 70.97 ± 3.38° (70.07 – 71.88°), aLDRA 91.72 ± 3.26° (90.84 – 92.59°), aCdPRA 100.5 ± 3.14° (99.62 – 101.3º), aCdDRA 79.95 ± 3.77° (78.94 – 80.96°) and SP 11.07 ± 1.87° (10.57 – 11.58°). The highest mean bias found for both observers was -1.6 to -1.8° for the angle aCdDRA. Sagittal procurvatum had the lowest mean bias for intra- and interobserver. Clinical significance: The results obtained showed that the methodology used in our study was repeatable and reliable. The values established for the normal radial anatomical angles are relevant for future use as a reference for surgical treatment of angular deformities, malunions, non-unions, comminuted fractures, and future orthopaedic research. © Schattauer 2016. Source


Gutierrez-Quintana R.,University of Glasgow | Cuesta-Garcia N.,University of Glasgow | Wessmann A.,Pride Veterinary Center | Johnston P.,University of Glasgow | Penderis J.,University of Glasgow
Journal of Feline Medicine and Surgery | Year: 2015

Polyneuropathies can have a variety of clinical presentations and tend to be rare in cats. In this report we describe a 6-year-old domestic shorthair cat with an acute and rapidly progressive onset of lower motor neuron and sensory signs affecting the spinal and cranial nerves. Histopathological examination revealed moderate-to-severe multifocal inflammatory infiltrates at the ventral and dorsal nerve roots, and dorsal spinal ganglia at the level of the L4 and cauda equina. The type and severity of inflammation varied between nerve roots, being composed of mainly neutrophils in some and mainly lymphocytes and macrophages in others. Immunohistochemistry showed a combination of neutrophils, macrophages and lymphocytes infiltrating the nerve roots and ganglia. The majority of the lymphocytes were T lymphocytes; only a few B lymphocytes were seen. Neurons within the affected ganglia showed central chromatolysis and necrosis. Wallerian-like degeneration and demyelination were observed in the nerve roots. A sensory and motor polyganglioradiculoneuritis was diagnosed. An autoimmune process similar to the acute motor and sensory neuropathy subtype of Guillain–Barré syndrome in humans or an infection by an unidentified agent were considered most likely. © ISFM and AAFP 2014. Source


Gutierrez-Quintana R.,University of Glasgow | Hammond G.,University of Glasgow | Wessmann A.,Pride Veterinary Center
Journal of Feline Medicine and Surgery | Year: 2014

Cystic lesions affecting the vertebral canal or spinal cord have rarely been reported in cats. A 3-year-old female neutered domestic longhair cat presented for evaluation of a 2-year-history of episodes of ataxia and paresis affecting all limbs. Neurological examination was consistent with a lesion in the C1-C5 spinal cord segments. Magnetic resonance imaging (MRI) showed a fluid-filled lesion at the occipito-atlanto-axial region causing dynamic spinal cord compression on flexion of the neck. The imaging characteristics were compatible with a juxta-articular cyst. To our knowledge, this is the first report of a fluid-filled lesion causing dynamic cervical spinal cord compression in a cat and highlights the importance of performing flexion-extension MRI views in diagnosing cases with dynamic spinal cord compression. © ISFM and AAFP 2013. Source


de Lima Dantas B.,University of Glasgow | de Lima Dantas B.,Pride Veterinary Center | Sul R.,University of Glasgow | Parkin T.,University of Glasgow | And 2 more authors.
Veterinary and Comparative Orthopaedics and Traumatology | Year: 2016

Objective: To retrospectively review and describe the incidence of complications associated with tibial tuberosity advancement (TTA) surgical procedures in a group of Boxer dogs (n = 36 stifles) and compare the data with a non-Boxer control population (n = 271 stifles). Methods: Retrospective analysis of medical records to identify all dogs that underwent TTA surgery due to cranial cruciate ligament disease. These records were categorized into two groups: Boxer dogs and non-Boxer dogs (controls-all other breeds). Results: Of the 307 stifles included, 69 complications were reported in 58 joints. The complication rate differed significantly for Boxer dogs (16/36 stifles) and non-Boxer dogs (42/271 stifles), corresponding to an odds ratio of 5.8 (confidence interval: 1.96-17.02; p-value <0.001). Boxer dogs were more likely to undergo revision surgery and to develop multiple complications. The incidence of tibial tuberosity fractures requiring surgical repair (2/36 versus 1/271) and incisional infections requiring antibiotic treatment (three in each group) was significantly higher in the Boxer group. Clinical significance: Boxer dogs had more major and multiple complications after TTA surgery than the control non-Boxer group; these complications included higher rates of revision surgery, tibial tuberosity fractures requiring stabilization, and infection related complications. The pertinence and value of breed-specific recommendations for cranial cruciate ligament disease appears to be a subject worthy of further investigation. © Schattauer 2016. Source

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