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Munakata M.,Preventive Medical Center
Nihon rinsho. Japanese journal of clinical medicine | Year: 2014

Work exerts considerable influence on human health. Recent meta-analysis has shown that work stress such as long working hours increases the risk of cardiovascular events. Long working hours has been reported to increase the risk of obesity, hypertension and diabetes although there are some conflicting data. Reduced physical activity, late dinner and shortening of sleep hours associated with long working hours could exacerbate lifestyle-related diseases. Neuroendocrine activation due to psychosocial stress may also be related to. In Japan, law concerning stabilization of employment of older persons has been enacted in 2013, indicating that number of old workers increase after this. It is important to establish healthy work environment for people to work until 65 yrs old without suffering from cardiovascular events. Source

Husson N.,University of Lorraine | Watfa G.,University of Lorraine | Watfa G.,French Institute of Health and Medical Research | Laurain M.-C.,University of Lorraine | And 5 more authors.
Journal of Nutrition, Health and Aging | Year: 2014

Background: Polypharmacy is an important concern for patient safety and has been associated with increased adverse drug reactions, hospitalization and mortality in the elderly. Objective: In light of the above, the present study aimed to assess the major characteristics associated with polypharmacy (≥ 4 drugs) in a larger population of apparently healthy older subjects over 60 years. Study-Design: Cross-sectional study. Setting: The preventive medical center (CMP) in Nancy. Participants: 2,545 volunteers (1,175 women, 1,370 men) aged 60 years and older (66 ± 4.8 years) were included from the Senior health examination study. Measurements: All subjects underwent clinical, biological examinations. Sociodemographic data, practice of regular physical activity and drug intake data were collected. A self-administered questionnaire of health status, psychological status and questions regarding falls were collected. Results: The prevalence of polypharmacy in this study was 29.9%. The number of drugs in polymedicated people was 5.67 ± 1.82 versus 1.32 ± 1.11 in non polymedicated people; p≤0.01. Multivariate analyses identified 6 independent variables associated with polypharmacy: age over 65 years (OR = 1.58 95% CI: [1.05-2.38]; p = 0.03), poor self-perceived health status (2.79 [1.80-4.31]; p ≤ 0,01), history of falls (1.66 [1.02-2.71]; p = 0.04), lack of a physical activity (1.50 [1.001-2.26]; p = 0.049), metabolic syndrome (3.17 [1.95-5.15]; p ≤ 0,01), low or medium education level (2.20 [1.24-4.30]; p = 0.02). Conclusion: Among community-dwelling people aged 60 years and over, in addition to the presence of several diseases and advanced age, the psychological and socio-educative factors may influence drug intake and polypharmacy in the elderly. Physicians should be take into account these considerations before issuing any prescriptions and review all medications used at every visit to avoid unnecessary addictions or dangerous drugdrug interactions. © 2014 Serdi and Springer-Verlag France. Source

Xin L.,Tongji University | Liu X.B.,Tongji University | Zheng L.,Tongji University | Zhang L.J.,Tongji University | And 9 more authors.
Chinese Medical Journal | Year: 2014

Background The prevalence of metabolic syndrome (MetS) increased recently and there was still not a screening index to predict MetS. The aim of this study was to estimate whether brachial-ankle pulse wave velocity (baPWV), a novel marker for systemic arterial stiffness, could predict MetS in Chinese community population.Methods A total of 2 191 participants were recruited and underwent medical examination including 1 455 men and 756 women from June 2011 to January 2012. MetS was diagnosed according to the criteria of the International Diabetes Federation (IDF). Multiple Logistic regressions were conducted to explore the risk factors of MetS. Receiver operating characteristic (ROC) curve was performed to estimate the ideal diagnostic cutoff point of baPWV to predict MetS.Results The mean age was (45.35±8.27) years old. In multiple Logistic regression analysis, the gender, baPWV and smoking status were risk factors to MetS after adjusting age, gender, baPWV, walk time and sleeping time. The prevalence of MetS was 17.48% in 30-year age population in Shanghai. There were significant differences (χ2=96.46, P <0.05) between male and female participants on MetS prevalence. According to the ROC analyses, the ideal cutoff point of baPWV was 1 358.50 cm/s (AUC=60.20%) to predict MetS among male group and 1 350.00 cm/s (AUC=70.90%) among female group.Conclusion BaPWV may be considered as a screening marker to predict MetS in community Chinese population and the diagnostic value of 1 350.00 cm/s was more significant for the female group. © 2014 Chinese Medical Association - Taipei. All rights reserved. Source

Tayama J.,Nagasaki University | Li J.,Tongji University | Munakata M.,Preventive Medical Center
Stress and Health | Year: 2016

We investigated the relationship between number of weekly working hours and the prevalence of diabetes in the urban Chinese population. Data regarding anthropometric measurements, fasting blood glucose level and number of hours worked per week were collected from 2228 workers in Shanghai, China (Mage = 44 years; 64% men). Participants were divided into three groups according to the number of hours worked per week (<45, 45-54 and ≥55), and multiple logistic regression analysis was conducted with diabetes as the dependent variable. Subjects with a HbA1c of 6.5% or above or those prescribed anti-diabetic medications were defined as having diabetes. The multivariate adjusted odds ratio for having diabetes was found to be significantly higher for those who worked ≥55 h per week compared with those who worked <45 h per week, but only for men. This finding indicates that working long hours could be a risk factor for diabetes in Chinese male workers. Copyright © 2014 John Wiley & Sons, Ltd. Source

Munakata M.,Preventive Medical Center | Honma H.,Preventive Medical Center | Akasi M.,Preventive Medical Center | Araki T.,Preventive Medical Center | And 5 more authors.
Hypertension Research | Year: 2011

The aim of this study was to examine whether additional repeated counselling further improves the health effects of limited, highly individualized lifestyle guidance in metabolic syndrome. One hundred and nine previously untreated metabolic syndrome patients received highly standardized and individualized lifestyle guidance for weight loss. A tentative goal of 5% weight reduction over the course of 2 months was set. Patients were then randomly assigned to either the multiple guidance group who received further counselling every 2 months (n52) or the single guidance group who received no further guidance until the final assessment 6 months later (n57). Baseline data between the multiple guidance and single guidance groups were similar. Body weight and waist circumference were significantly reduced, and liver function, lipid profiles and glucose metabolism were significantly improved in both groups. After adjustment for baseline data, the multiple guidance group showed considerably higher reduction in waist circumference and fasting blood sugar concentration than the single guidance group. These data suggest that additional counselling further improved the antidiabetic effects of limited individualized lifestyle guidance in metabolic syndrome. © 2011 The Japanese Society of Hypertension All rights reserved. Source

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