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Kazemijaliseh H.,Reproductive Endocrinology Research Center | Ramezani Tehrani F.,Reproductive Endocrinology Research Center | Behboudi-Gandevani S.,Reproductive Endocrinology Research Center | Khalili D.,Prevention of Metabolic Disorders Research Center | And 2 more authors.
Iranian Journal of Endocrinology and Metabolism | Year: 2015

Introduction: Normal menstruation is one of important indicators of the general health of reproductive-aged women. We aimed to investigate the prevalence of menstrual disorders and its related factors. Materials and Method: This cross-sectional study was conducted among women participants of the Tehran Lipid and Glucose Study, a population-based study aimed identify the prevalence of noncommunicable diseases from March 2013 to 2014. A total of 1393 women, aged 15-49 yr were included and all pregnant, breastfeeding and menopausal women were excluded. Socio-demographic characteristics and menstruation patterns were assessed by a standardized ad-hoc questionnaire. Menstruation was categorized based on last FIGO definitions. Data analyzed using SPSS version 11.0 (SPSS-Inc., Chicago-IL), 0.05 was set as significant level. Results: Mean age of participants was 37.7 (11) y. The results showed that 64.1% of subjects had normal menstruation and 35.8% experienced different forms of menstrual disorders. Heavy menstrual bleeding was one of the most prevalent disorders (17.2%). Prevalence of menstrual disorders was statistically higher in women <20 yr (47.7%) and >40yr (45.5%) than women between the 20-40 yr age range (P=0.001). Irregular menstrual bleeding in >20 yr, heavy menstrual bleeding in 20-40 yr and > 40yr were the most common menstrual disorders. The results remain unchanged for age and BMI after adjustment for potential confounders (OR: 1.08, CI 95%: 1.07-3.97; P<0.03), (OR: 1.05, CI 95%: 1.02-5.04; P<0.04), respectively. Conclusion: Our findings showed that menstrual disorders are prevalent as one-third of reproductive aged women suffer from one or more menstrual disorders. Understanding the prevalence of menstrual disorders could help health care providers to identify some serious diseases, and prioritize strategies to promote these women’s quality of life. © 2015, Endocrine Research Center. All rights reserved. Source


Derakhshan A.,Prevention of Metabolic Disorders Research Center | Tohidi M.,Prevention of Metabolic Disorders Research Center | Arshi B.,Prevention of Metabolic Disorders Research Center | Khalili D.,Prevention of Metabolic Disorders Research Center | And 2 more authors.
Diabetic Medicine | Year: 2015

Aims: To examine the association of fasting insulin, insulin resistance and reduced β-cell function with incident Type 2 diabetes and pre-diabetes (isolated impaired fasting glucose/isolated impaired glucose tolerance and combined impaired fasting glucose/impaired glucose tolerance). Methods: An Iranian population comprising 1532 men and 2221 women, aged ≥ 20 years, with normal fasting glucose and normal glucose tolerance at baseline, were enrolled in the study. Multivariable Cox proportional hazard models were used to calculate the hazard ratios and 95% CIs of fasting insulin, updated homeostasis model assessments of insulin resistance and β-cell function for incident Type 2 diabetes, isolated impaired fasting glucose, isolated impaired glucose tolerance and combined impaired fasting glucose/impaired glucose tolerance. Results: During a median follow-up of 9.2 years, the annual incidence rates (95% CI) of diabetes were 3.73 (2.74-4.94) and 4.06 (3.21-5.06) per 1000 person-years in men and women, respectively. In both men and women, fasting insulin and homeostasis model assessment of insulin resistance (≥ 75th percentile) were significantly associated with incident diabetes and combined impaired fasting glucose/impaired glucose tolerance; however, reduced β-cell function as measured by homeostasis model assessment of β-cell function (< 25th percentile) was associated with incident isolated impaired fasting glucose solely in men [hazard ratio 1.35 (95% CI 1.02-1.78)] in multivariable analysis including waist-hip ratio). Hyperinsulinaemia, insulin resistance and β-cell dysfunction were not related to the incidence of isolated impaired glucose tolerance in either gender. Conclusions: Fasting hyperinsulinaemia and insulin resistance were strong risk factors for progression to diabetes and combined impaired fasting glucose/impaired glucose tolerance in a population with normal fasting glucose/normal glucose tolerance. In addition, impaired β-cell function at baseline was related to the development of isolated impaired fasting glucose only in men and, in both men and women, neither insulin resistance nor β-cell dysfunction were associated with incident isolated impaired glucose tolerance. © 2014 The Authors. Source


Bozorgmanesh M.,Prevention of Metabolic Disorders Research Center | Hadaegh F.,Prevention of Metabolic Disorders Research Center | Zabetian A.,Prevention of Metabolic Disorders Research Center | Azizi F.,Shahid Beheshti University of Medical Sciences
Diabetic Medicine | Year: 2011

Aim: To investigate the effects of height and hip circumference, individually and in combination with waist circumference, on incident diabetes. Methods A total of 1589 men and 2132 women, free of diabetes at baseline aged ≥20years participated in a 6-year follow-up examination. The standard 2-h post-challenge plasma glucose test was performed at baseline and during follow-up. The Cox model was used to regress the hazard of diabetes on height and hip circumference individually and in combination with waist circumference. Results Median follow-up was 6 years, with a total of 9433 and 12607 person-years follow-up among men and women, respectively. The incidence rate of diabetes (95%CIs) was 9.0 (7.6-11.5) and 11.0 (9.6--13.4) per 1000persons per year in men and women, respectively. Among men, after multiple adjustments, the anthropometric measures were no longer associated with incident diabetes. Among women, the age-adjusted hazard ratio (95%CIs) of diabetes was 0.80 (0.61-1.04) for height, 1.39 (1.21-1.60) for hip circumference and 1.86 (1.59-2.17) for waist circumference. After further adjustment for waist circumference, the hazard ratios were 0.69 (0.53-0.90) for height and 0.76 (0.61-0.96) for hip circumference. These inverse associations resisted multiple adjustments. The hazard ratio for waist circumference increased by 7 and 54% when height and hip circumference were included in the models. Conclusion We observed that height and hip circumference were inversely associated with incident diabetes among women and that these associations could be explored by considering the effect of waist circumference. The risk of diabetes attributable to waist circumference might be underestimated were the effects of height and hip circumference not considered. © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK. Source


Ehteshami-Afshar S.,Prevention of Metabolic Disorders Research Center | Momenan A.,Prevention of Metabolic Disorders Research Center | Hajshekholeslami F.,Prevention of Metabolic Disorders Research Center | Azizi F.,Shahid Beheshti University | Hadaegh F.,Prevention of Metabolic Disorders Research Center
Annals of Human Biology | Year: 2014

Aim: To examine the association of different smoking groups with cardiovascular disease (CVD), coronary heart diseases (CHD) and CVD attributed death and death due to all causes in a male Tehranian population. Methods: From a population-based study 3059 male individuals, aged 30 years, free of CVD at baseline were evaluated for a median of 9.3 years. The adjusted hazard ratios (HRs) for incident CVD/CHD, total and CVD mortality regarding their smoking status were calculated using Cox proportional regression analysis, considering never smoking as reference. Results: A total of 158 deaths, in which 78 were CVD attributable, occurred. Considering CVD and CHD events, this study identified 299 and 257 events, respectively. Being a past smoker significantly increased the risk of CVD events (HR=2.42, CI=1.28-0.56), however, it has no effect on CHD events, total and CVD mortality. Being a current smoker (more than 10 cigarettes a day) dramatically increased the risk of CVD/CHD events and total/CVD mortality. However, smoking less than 10 cigarettes per day only increased the risk of CVD (HR=2.12, CI=1.14-3.95) and its mortality (HR=4.57, CI=1.32-15.79). Conclusion: The findings indicate that smoking increases the risk of incident CVD/CHD, total and CVD mortality, particularly CVD mortality. These outcomes were attributable to the daily amount of cigarettes smoked. Past smokers still had higher risk for CVD events, which cessation may not reduce. © 2014 Informa UK Ltd. Source


Momenan A.,Prevention of Metabolic Disorders Research Center | Delshad M.,Shahid Beheshti University of Medical Sciences | Mirmiran P.,Shahid Beheshti University of Medical Sciences | Ghanbarian A.,Prevention of Metabolic Disorders Research Center | And 2 more authors.
Iranian Journal of Endocrinology and Metabolism | Year: 2012

Introduction: Physical activities represent an independent risk factor for a number of chronic diseases. The aim of this study was to assess physical inactivity in a sample of Tehranian adults. Materials and Methods: We selected 7285 TLGS participants (≥ 20 years), who had completed physical activity questionnaires between 2002-2004. Leisure time physical activity level was assessed using the modifiable Activity Questionnaire (MAQ), with each activity being weighted by its relative intensity, referred to as a Metabolic Equivalent (MET). Subjects were asked to report the activities they had participated in during past 12 months and to estimate the frequency and duration for each leisure time activity indentified and were categorized into the active and inactive groups. Results: The overall prevalence of inactivity was 69.8% and only 30.2% (95%CI=27.2-33.1%) of males and 30.3% (95%CI=27.7-32.8%) of females were considered active. In males, the prevalence of inactivity increased with age and the highest rate of physical inactivity was observed in the 40-49 year group. There was a statistically significant decrease in leisure time physical activity level (LTPA) with increasing body mass index, and smoking and hours of work. A positive association was observed between LTPA and high educational levels in males. Moreover, a statistically significant difference was found between the physical activity and occupations between men and women (p<0.05). Conclusions: Findings of the present study showed that a high prevalence of physical inactivity among Tehranian adults, raising concerns about public health, and necessitating health policies encouraging the population to be more active. Source

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