Time filter

Source Type

Ma H.-M.,Shandong Cancer Hospital | Wang S.-F.,Shandong Cancer Hospital | Leng L.,Cancer Prevention and Treatment Center | Zhu F.,Cancer Prevention and Treatment Center | And 4 more authors.
Chinese Journal of Cancer Prevention and Treatment

OBJECTIVE: To analyze the results of breast cancer screening program in Feicheng, 2008-2011, find out the incidence of breast cancer, and explore the ideal early detection mode of screening for breast cancer. METHODS: Two schemes were used in the programme. The first one was that all subjects received clinical breast examination (CBE) and ultrasonography (US), and suspicious cases received mammography (MAM). Totally 3000 citizen women aged 45-64 underwent the second screening sessions (CBE, MAM, US used in combination). All cases will ultimately be diagnosed by pathology. χ2 test and screening test were used to analyze the results of the programme. RESULTS: From 2008 to 2011, the average detection rate of breast cancer in the first screening populations was 122.3/100000 (26/21256), and the rate of the reviewing population was 66.8/100000 (3/4493). There were statistical differences among the detection rates of different age groups between the citizen and rural women after standardization. The total standardized rate of the citizen women was 168.6/100000 while the rate in rural areas was 3.4/100000. Some rural women were reluctant to participate in breast cancer screening, and the early cancer detection rate was lower. The accuracy of clinical examination, ultrasonography and mammography used together was relatively higher than other ways. The first scheme was more economic and effective than the second one though there were no statistical differences between them. CONCLUSIONS: The screening suggests a higher detection rate of breast cancer in women in Feicheng. Screening and diagnosis for breast cancer should be strengthened and standardized in rural areas. The scheme that MAM was used in high-risk groups who were determined by CBE and US was effective and suitable for promotion in community application. Source

Zhao X.-Z.,Tianjin Medical University | Yang B.-H.,Cancer Prevention and Treatment Center | Yu G.-H.,Cancer Prevention and Treatment Center | Liu S.-Z.,Cancer Prevention and Treatment Center | Yuan Z.-Y.,Tianjin Medical University
Archives of Dermatological Research

There have been a few epidemiological studies reporting VDR polymorphisms including Fok1, Bsm1, Apa1 and Taq1 with skin cancer incidence and, therefore, risk. The results, however, are controversial, often due to smaller sample size. Concerning most of the studies were performed on Caucasian population, we conducted this comprehensive analysis to better understand roles of the polymorphisms in skin cancer development among Caucasian population. The results showed that Fok1 polymorphism was associated with an overall significantly increased risk of skin cancer (Ff vs. FF: OR = 1.20, 95 % CI = 1.01-1.44; ff vs. FF: OR = 1.41, 95 % CI = 1.08-1.84; Ff + ff vs. FF: OR = 1.26, 95 % CI = 1.04-1.53). Besides, we found that Taq1 polymorphism could contribute to non-melanoma skin cancer susceptibility (Tt vs. TT: OR = 1.88, 95 % CI = 1.29-2.74; tt vs. TT: OR = 2.00, 95 % CI = 1.22-3.28; Tt + tt vs. TT: OR = 1.92, 95 % CI = 1.35-2.73). We also found that the Apa1 polymorphism is associated with skin cancer development (Aa vs. AA: OR = 1.27, 95 % CI = 1.05-1.53; Aa + aa vs. AA: OR = 1.23, 95 % CI = 1.04-1.47) and NMSC subgroup (Aa vs. AA: OR = 1.72, 95 % CI = 1.51-2.57; Aa + aa vs. AA: OR = 1.50, 95 % CI = 1.03-2.17). No significant association was observed between the Bsm1 polymorphism and skin cancer risk. The current meta-analysis shows that Fok1, Taq1 and Apa1 may be the susceptibility biomarker for skin cancer in Caucasians. © 2014 Springer-Verlag. Source

Wang Z.-G.,Cancer Prevention and Treatment Center | Lin Z.-Q.,Cancer Prevention and Treatment Center | You Z.-J.,Cancer Prevention and Treatment Center | Zheng J.-L.,Cancer Prevention and Treatment Center | And 5 more authors.
Chinese Journal of Cancer Prevention and Treatment

OBJECTIVE: To summurise the resection experience of the second-hilar tumors. METHODS: The clinical data of 137 cases of the resection of the second-hilar tumors were retrospectively analyzed, and the related literature was reviewed. RESULTS: All operations of the whole group patients were successful. Thirty cases occured the postoperative complications and the complication rate was 21.9% (30/137), including 7 cases of postoperative surgical field bleeding, 4 cases of upper gastrointestinal bleeding, 3 cases of biliary fistula, 3 cases of subphrenic abscess, 8 cases of liver functional compensation insufficiency, and 5 cases of hepatic hydrothorax. In the perioperative period, one case died for the early postoperative bleeding, one case for the upper gastrointestinal bleeding, two cases for liver failure, one case for pulmonary embolism due to lung metastases, and one case for the widespread brain and spinal cord metastases and giving up treatment. The total perioperative mortality was 4.4%(6/137). CONCLUSION: The resection of second hilar tumors is safe. Source

Discover hidden collaborations