Precision NanoSystems Inc.
Precision NanoSystems Inc.
Garg S.,Precision NanoSystems Inc |
Heuck G.,Precision NanoSystems Inc |
Ip S.,Precision NanoSystems Inc |
Ramsay E.,Precision NanoSystems Inc
Journal of Drug Targeting | Year: 2016
Microfluidic devices are mircoscale fluidic circuits used to manipulate liquids at the nanoliter scale. The ability to control the mixing of fluids and the continuous nature of the process make it apt for solvent/antisolvent precipitation of drug-delivery nanoparticles. This review describes the use of numerous microfluidic designs for the formulation and production of lipid nanoparticles, liposomes and polymer nanoparticles to encapsulate and deliver small molecule or genetic payloads. The advantages of microfluidics are illustrated through examples from literature comparing conventional processes such as beaker and T-tube mixing to microfluidic approaches. Particular emphasis is placed on examples of microfluidic nanoparticle formulations that have been tested in vitro and in vivo. Fine control of process parameters afforded by microfluidics, allows unprecedented optimization of nanoparticle quality and encapsulation efficiency. Automation improves the reproducibility and optimization of formulations. Furthermore, the continuous nature of the microfluidic process is inherently scalable, allowing optimization at low volumes, which is advantageous with scarce or costly materials, as well as scale-up through process parallelization. Given these advantages, microfluidics is poised to become the new paradigm for nanomedicine formulation and production. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Leaver T.,Precision NanoSystems Inc.
Drug Development and Delivery | Year: 2017
Nanoparticles, and liposomes in particular, have been used for drug delivery in cancer and inflammatory disease therapies for several years, but traditional manufacturing methods are labor intensive, hard to reproduce, and difficult to scale up. Because the characteristics of nanoparticles are sensitive to manufacturing conditions, precise and reproducible control of the manufacturing process is necessary to ensure consistent particle characteristics at different scales of production. Precision NanoSystems Inc., based in Vancouver, Canada, has developed a proprietary technology - the NanoAssemblr™ platform - for the rapid development of nanoparticles and seamless scale-up for clinical studies and commercial production. This technology is transforming the development and manufacturing of a range of nanoparticle formulations from a hit-and-miss affair to a standardized process, accelerating novel nanomedicines from the bench to the clinic. © 2017 Drug Development & Delivery.
Walsh C.,University of British Columbia |
Ou K.,University of British Columbia |
Belliveau N.M.,Precision NanoSystems Inc. |
Leaver T.J.,Precision NanoSystems Inc. |
And 13 more authors.
Methods in Molecular Biology | Year: 2014
A simple, efficient, and scalable manufacturing technique is required for developing siRNA-lipid nanoparticles (siRNA-LNP) for therapeutic applications. In this chapter we describe a novel microfluidic-based manufacturing process for the rapid manufacture of siRNA-LNP, together with protocols for characterizing the size, polydispersity, RNA encapsulation efficiency, RNA concentration, and total lipid concentration of the resultant nanoparticles. © 2014 Springer Science+Business Media, New York.