Littleton, CO, United States
Littleton, CO, United States

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Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase II | Award Amount: 838.28K | Year: 2012

DESCRIPTION (provided by applicant): This fast-track application requests support to develop and field test software for functional communication training for children with autism and related neurodevelopmental disorders. Aimed principally at behavior therapists, special educators, and speech/language professionals, the software will support implementation of augmentative/alternative communication (AAC) approaches that use pictures to aid functional communication. Picture-aided communication systems are nowwidely used in functional communication training, most notably in the widely used PECS (Picture Exchange Communication System). The proposed product will address three critical stages in such functional communication training: (1) establishing the first instances of reliable discrimination among pictures and corresponding objects, (2) accelerating expansion of the picture-discrimination repertoire, and (3) establishing and expanding pictures sequences to support progressively more capable picture-aided communication. The working title of the product is Picture-Aided Communication System Manager (PACSMan). The scientific foundation for PACSMan is extensive, deriving from dozens of publications in professional journals over the past three decades. The programwill manage the therapist-child interface within a PECS-like teaching environment. The software will (1) display sequences of stimulus items and their configurations to be presented, (2) allow the therapist to quickly and conveniently enter data corresponding to the child's behavior, (3) make automated on-the-fly queries of an individual-child database in order make decisions concerning the nature of the teaching sequences (i.e., when to add new items, when to accelerate teaching, when to remediate, etc.),and generally support an ongoing process of optimizing individualized instruction in picture-aided communication. This STTR project features a unique partnership between the UMMS Shriver Center, which established the evidence basis for the product, and Praxis, Inc., which contributes intellectual property whereby the product can be rapidly and cost-effectively developed. PUBLIC HEALTH RELEVANCE: The primary focus of this research is development of communication in children with little or no functional language due to autism or other neurodevelopmental disorder. The specific emphasis is on methods to support symbolic communication in such children. We hope that our research will lead to methods that will make positive outcomes of behavior therapy more robustand reliable.


Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 260.86K | Year: 2011

DESCRIPTION (provided by applicant): The proposed project is designed to fill an important yet unmet need by developing an online training program that has the potential for reaching all emergency managers, responders and students in the field of emergencypreparedness with a specific focus on individuals with disabilities. Pursuing this objective, the applicant organization, Praxis, Inc., and the Eunice Kennedy Shriver Center at the University of Massachusetts Medical School will work together to develop,implement and evaluate a comprehensive emergency preparedness educational and training curriculum, Emergency Operations Plans for Individuals with Disabilities (EOPD). The Phase 1 modules, titled Introduction to Emergency Plans for Individuals with Disabilities and Identification of People with Disabilities in the Community: Mapping Techniques and Technology, will be part of a comprehensive curriculum designed to train emergency preparedness staff to anticipate, plan for and address the likely needs of children and adults with disabilities before, during, and after emergencies. The curriculum will be an anytime, anywhere training program available to anyone with Internet access. The product will be a fully hosted, Web-based distance learning instructionalprogram in which lessons will build upon one another, assisting learners to acquire a foundation of knowledge upon which more complex skill sets can be built. Learners who participate will apply knowledge acquired through the course to simulated or real life situations and adverse events that could potentially occur with this population during emergencies. Self-assessments will be built into each module to help them accurately and systematically assess their skills and develop learning plans to improve whenneeded. Accomplishing the aims of this project will ultimately impact the needs of individuals with disabilities as they become better prepared to confront emergencies and/or disasters. PUBLIC HEALTH RELEVANCE: The proposed project and the resulting product will directly benefit individuals who provide emergency preparedness services to the public. By teaching emergency managers, responders and students about the unique challenges facing people with disabilities, they will be better informed, readyand able to serve the unique needs of this population. The project has three major objectives: (1) to design, develop, implement, and evaluate a new on-line training course titled Emergency Planning and Response for Individuals with Disabilities, (2) to develop a commercially viable software prototype, and (3) to evaluate the resulting program to determine the usability of the software and the effectiveness of the curriculum in disability relevant issues to emergency preparedness professionals.


Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 1.19M | Year: 2011

DESCRIPTION (provided by applicant): Individuals with intellectual and developmental disabilities (I/DD) have more untreated caries and a higher prevalence of gingivitis and other periodontal diseases than the general population (NIDCR, 2009). In order to address this health care disparity, more dentists are needed who understand and are trained to meet the needs of this population. Few in-depth training options are currently available for dentists in general practice. The purpose of this Phase I/II FastTrack STTR proposal is to develop and evaluate the effectiveness of an online training program in special needs dentistry for dentists in general practice. Continuing education units will be offered. The program, named Developmental Disabilities DentistryOnline, will be asynchronous (available anytime, anywhere) and, importantly, will exploit advances in media-supported instructional technology, to include virtual clinical simulations, interactive case studies, various Flash-based video and graphic learning objects, embedded self-assessments and note-taking options. Course modules will address risk management, preventive care, medical considerations associated with specific disabilities, restorative dentistry, behavioral support techniques, and a special section on autism spectrum disorders. Praxis, Inc., the host organization, will collaborate with faculty and staff at the Eunice Kennedy Shriver Center at University of Massachusetts Medical School (Shriver/UMASS Medical) and Tufts University School of Dental Medicine to develop and test the program through a host of systematic formative and summative evaluation methods. PUBLIC HEALTH RELEVANCE: The proposed project and the resulting product will directly benefit dentists who provide services and support to children and adults with intellectual and other developmental disabilities. The project has three major objectives: (1) to Design, develop, implement, and evaluate 6 new on-line training courses in oral health care for a special needs population, (2)to develop a commercially viable software prototype, and (3) to evaluate the resulting program to determine the usability of the software and the effectiveness of the curriculum.


Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase II | Award Amount: 1.30M | Year: 2011

DESCRIPTION (provided by applicant): The proposed project is designed to fill an extremely important yet unmet need by developing an alternative training mechanism that has the potential for reaching all personnel responsible for risk management and quality improvement in programs that provide services to persons with mental retardation/developmental disabilities (MRDD) and the public agency staff that oversee such programs. Pursuing this objective, the applicant organization, Praxis, Inc., and Eunice Kennedy Shriver Center at the University of Massachusetts Medical School will work together to develop, implement, and evaluate a comprehensive training curriculum to provide knowledge and practical skills in the first of a series of on-line courses for training staff in the use of analytic tools for Risk Management in Developmental Disabilities (RMDD). The training curriculum will be an anytime, anywhere training program available to anyone with Internet access. The program, RMDD, is intended to meet the essential needs of public and private agencies to assure the health, safety and welfare of a very vulnerable population that is at increased risk of harm and that is being served in over 145,000 residential settings across the nation, a basic assurance all public agencies must meet to receive federal HCBS and ICF/MR funding. Course work will teach contemporary, evidence-based methods and procedures in RMDD specifically adapted to the unique nature of services directed at individuals with developmental disabilities. The product, RMDD will be a fully hosted, Web-based distance learning instructional program in which lessons will build upon one another, assisting learners to acquire a foundation of knowledge upon which more complex skill sets can be built. Learners who participate in RMDD will apply knowledge acquired through their readings to simulated or real life situations and adverse events that commonly occur in service settings serving the MRDD population. Self-assessments will be built into each module to help them accurately and systematically assess their skills and develop learning plans to improve when needed. PUBLIC HEALTH RELEVANCE: The proposed project and the resulting product will directly benefit individuals who provide services and support to children and adults with intellectual and other developmental disabilities. The project has three major objectives: (1) to Design, develop, implement, and evaluate 6 new on-line training courses in risk management techniques and skills, (2) to develop a commercially viable software prototype, and (3) to evaluate the resulting program to determine the usability of the software and the effectiveness of the curriculum in teaching risk management skills.


Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase II | Award Amount: 905.26K | Year: 2013

DESCRIPTION (provided by applicant): Individuals with intellectual and developmental disabilities (I/DD) have more untreated caries and a higher prevalence of gingivitis and other periodontal diseases than the general population (NIDCR, 2009). In order to address this health care disparity, more dentists are needed who understand and are trained to meet the needs of this population. Few in-depth training options are currently available for dentists in general practice. The purpose of this Phase I/II FastTrack STTR proposal is to develop and evaluate the effectiveness of an online training program in special needs dentistry for dentists in general practice. Continuing education units will be offered. The program, named Developmental Disabilities DentistryOnline, will be asynchronous (available anytime, anywhere) and, importantly, will exploit advances in media-supported instructional technology, to include virtual clinical simulations, interactive case studies, various Flash-based video and graphic learning objects, embedded self-assessments and note-taking options. Course modules will address risk management, preventive care, medical considerations associated with specific disabilities, restorative dentistry, behavioral support techniques, and a special section on autism spectrum disorders. Praxis, Inc., the host organization, will collaborate with faculty and staff at the Eunice Kennedy Shriver Center at University of Massachusetts Medical School (Shriver/UMASS Medical) and Tufts University School of Dental Medicine to develop and test the program through a host of systematic formative and summative evaluation methods. PUBLIC HEALTH RELEVANCE The proposed project and the resulting product will directly benefit dentists who provide services and support to children and adults with intellectual and other developmental disabilities. The project has three major objectives: (1) to Design, develop, implement, and evaluate 6 new on-line training courses in oral health care for a special needs population, (2)to develop a commercially viable software prototype, and (3) to evaluate the resulting program to determine the usability of the software and the effectiveness of the curriculum.


Patent
Praxis Inc. | Date: 2016-06-21

High strength implantable devices having complex surfaces are injection molded from powder metal wherein the surface is defined by a monolithic insert made by additive manufacturing. The insert defines the surface texture of the device and may also include a portion to form an ingrowth texture and a portion to form a substrate interface texture. The tensile bond strength of the texture is 20 Mega Pascal or greater.


Patent
Praxis Inc. | Date: 2013-06-28

In one embodiment, the present invention is a porous article including a porous portion with an average ratio between about 2:1 and about 5:1 of major pore size to minor pore size, having a substantially uniform pore distribution and a porosity of at least 70 percent, the porous article for use as a biological implant. The biological implant can be, for example, an acetabular cup.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2013

DESCRIPTION (provided by applicant): We request Phase 1 SBIR funding to develop Set2Read-AK (Alphabet Knowledge), the first component of a larger effort to develop evidence-based, broadly distributable solutions to a widely acknowledged challenge - establishing reading readiness in children with intellectual and developmental disabilities (IDD) and others who have atypical difficulty in learning such skills. The product will address a meaningful subset of readiness skills identified by state-of-the-scienceevaluation groups such as the National Early Literacy Panel as predictive of subsequent success in learning to read, specifically discrimination of letters that constitute the written alphabet in its many forms and relations of those letters with their corresponding spoken counterparts in English. Set2Read-AK will be the first product to feature comprehensive implementation of next-generation evidence- based techniques for directing attending to the distinguishing features of letters and letter names. As such, it will provide a model for other programs and products that may use this instructional technology for directing attending. Set2Read-AK will be implemented on the current generation of highly capable portable tablet devices (with their well-establishedproduct delivery systems via the app stores). Aspects of the program may be adapted also for implementation on handheld devices such as the iPhone. While the product is intended mainly to meet the needs of students with IDD, it may be useful also to helptypically developing children learn more quickly than they might do so without it - thus potentially expanding the market for the product. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The main focus of this research is development of reading readiness skills in children with intellectual disabilities (IDs). We plan to develop a curriculum that will implement procedures based on relevant evidence from behavioral and educational science research. The curriculum will be implemented initially onhandheld tablets (e.g., iPad, Android, etc.). When made broadly available, we believe that the product will greatly improve reading readiness learning outcomes for many children with IDs.


Patent
Praxis Inc. | Date: 2014-01-08

High strength implantable devices having complex surfaces are injection molded from powder metal wherein the surface is defined by a monolithic insert made by additive manufacturing. The insert defines the surface texture of the device and may also include a portion to form an ingrowth texture and a portion to form a substrate interface texture. The tensile bond strength of the texture is 20 Mega Pascal or greater.


Patent
Praxis Inc. | Date: 2015-07-27

In one embodiment, the present invention may be a method of making a porous biocompatible metal article by combining a metal powder with a homogenizing aid to form metal granules, including blending the metal granules and an extractable particulate to form a composite, forming the composite into a green article, removing the extractable particulate from the green article to form a metal matrix and pore structure, and sintering the metal matrix and pore structure. Furthermore the present invention may include a second homogenizing aid combined with the extractable particulate. The present invention also includes shaping the metal matrix and pore structure with or without the use of a binder.

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