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Joshi M.,Pravara Institute of Medical Sciences | Patil R.,K M Shah Dental College
Journal of Cancer Research and Therapeutics | Year: 2010

Background: Tumor markers are a major part of the secondary prevention and thus the detection of malignancies. Neoplasms often have an increased concentration of sialic acid on the tumor cell surface and are shed or secreted by some of these cells which increase the concentration in blood. Materials and Methods: The study was conducted on 90 subjects equally divided into three groups viz, healthy individuals, oral cancer and precancer. The estimation of serum total sialic acid level was done according to Plucinsky et al by resorcinol reagent method. The statistical analysis was carried out by using SPSS 10.0 software. Results: The mean serum total sialic acid (TSA) level in oral precancer and oral cancer group was statistically significant (P<0.05). In oral cancer group when stage I and stage II were compared with stage III and stage IV, it was statistically significant (P<0.05). Histopathologically, oral cancer and precancer did not show statistically significant values (P>0.05). The present study also suggested that no correlation exists between habit of tobacco chewing/betel nut chewing/smoking or alcohol consumption with that of serum total sialic acid levels. Conclusion: Serum total sialic acid levels can be used as an adjunctive diagnostic marker in head and neck cancer. Source

Astagi P.B.,Pravara Institute of Medical Sciences
Pravara Medical Review | Year: 2014

The presence of displaceable denture bearing tissue often presents difficulty in making complete dentures. Unless managed properly such flabby tissues affect retention and stability of complete dentures. In particular, problems arise during impression making when forces distort the mobile denture bearing area. Various impression techniques have been proposed to solve this problem. This article presents a case report of management of flabby tissues over anterior maxillary ridge by Watson's Window technique. Source

Srivastava K.,Armed Forces Medical College | Chaudhury S.,Pravara Institute of Medical Sciences
The Scientific World Journal | Year: 2014

Psychological aspects of adjustment to amputation are varied and not addressed in the present treatment regime. There is no research evidence available of psychological intervention and outcome in Indian scenario. One hundred and seventy-three consecutive patients with limb amputations were randomly assigned to psychotherapeutic intervention module (PIM, study group) (n = 90) and treatment as usual group (TAU, control group) (n = 83). Patients with psychotic disorder were excluded from the study. Carroll Rating Scale for Depression (CRSD), State-Trait Anxiety Inventory (STAI), Amputees Body Image Scale (ABIS), and Impact of Event Scale (IES) along with specially designed information schedule were administered individually. Structured psychotherapeutic module was developed for the intervention. Patients in PIM group were given six therapy sessions, addressing the specific areas of concern. All patients were evaluated on the same tools after two months of therapy. Analysis showed that after treatment a significant reduction in scores was noted on CRSD, STAI, ABIS, and IES in the PIM group. On the TAU group a significant reduction was seen only in the ABIS. The psychological intervention module proposed by authors was efficacious in alleviating the psychological distress, depression, and anxiety and thus was vastly superior to the conventional method of management of amputees. © 2014 Kalpana Srivastava and Suprakash Chaudhury. Source

Singh B.,Pravara Institute of Medical Sciences
Pravara Medical Review | Year: 2013

A four-year retrospective study was carried out in which all patients of acute poisoning admitted to Pravara Rural Hospital, Loni during the period: January 01, 2002 to December 31, 2005 were included. A total 1856 patients were admitted to Intensive Care Unit (ICU) of which 385 (20.7%) patients were due to acute poisoning, of these, 312 (81.0%), were due to agro & horticultural poisons. In 13.8 % of the cases identity of the poison could not he ascertained. Organophosphates were the most commonly misused poison irrespective of age, sex and seasons. Both hospitalizations and deaths occurred more frequently in males and incidence was highest in the age group of 21 to 35 years. The study highlights the problem of poisoning in the region. Since the majority of cases of poisoning are from low socioeconomic status, poisonings from agricultural and horticultural chemicals are an important public health problem. Preventive efforts need to incorporate the fact that many serious cases, such as organophosphate poisonings are suicidal in nature. Source

Kachewar S.,Pravara Institute of Medical Sciences | Sankaye S.,Pravara Institute of Medical Sciences
Mens Sana Monographs | Year: 2013

Science is strengthened not by research alone, but by publication of original research articles in international scientific journals that gets read by a global scientific community. Research publication is the ′heart′ of a journal and the ′soul′ of science - the outcome of collective efforts of authors, editors and reviewers. The publication process involves author-editor interaction for which both of them get credit once the article gets published - the author directly, the editor indirectly. However, the remote reviewer who also plays a key role in the process remains anonymous and largely unrecognised. Many potential reviewers therefore, stay away from this ′highly honorary′ task. Appropriate peer review controls quality of an article and thereby ensures quality and integrity of the journal. Recognising and rewarding the role of the reviewer is therefore vital. In this article, we propose a novel idea of Reviewer Index (RI), Reviewer Index Directory (RID) and Global Reviewer Index Directory (GRID), which will strengthen science by focussing on the reviewer, as well as the author. By adopting this innovative Reviewer Centric Approach, a new breed of well-trained reviewers of high quality and sufficient quantity will be available for eternity. Moreover, RI, RID and GRID would also enable grading and ethical rewarding of reviewers.© MSM 2013. Source

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