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Jaiswal S.,Advance Institute of Biotech and Paramedical science | Mishra A.P.,Advance Institute of Biotech and Paramedical science | Srivastava A.,Pranveer Singh Institute of Technology
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Benzoheterocycles such as benzothiazoles can serve as unique and versatile scaffolds for experimental drug design. Among the all benzohaterocycles, benzothiazole has considerable place in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. The small and simple benzothiazole nucleus possesses numerous pharmacological activities like- antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. Since, a wide range of different reactions are available for synthesizing 2-substituted benzothiazole nucleus and its derivatives by using different type of catalysts but a real need exists for new procedures that support many kinds of structural diversity and various substitution. The present review focuses on the different kind of reactions involved in synthesis as well as cyclisation of benzothiazole nucleus and its derivatives.

Kumar K.,NIMS University | Kumar K.,Global Institute of Pharmaceutical Education and Research | Rai A.K.,Pranveer Singh Institute of Technology
Tropical Journal of Pharmaceutical Research | Year: 2012

Purpose: To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence time and increased drug bioavailability. Methods: Floating microsphere were prepared by emulsion solvent diffusion method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1. The floating microspheres were evaluated for flow properties, particle size, incorporation efficiency, as well as in-vitro floatability and drug release. The shape and surface morphology of the microspheres were characterised by optical and scanning electron microscopy. Result: The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 251 - 387 μm, 74.6 - 90.6 %, and 72.6 - 83.5 %, and 45.5 - 82.0 %, respectively. Maximum drug release after 20 h was 47.1, 55.7, 69.4 and 81.3 % for formulations F1, F2, F3 and F4, respectively. Scanning electron micrographs indicate pores both on the surface and interior of the microspheres. Conclusion: The developed curcumin microsphere system is a promising floating drug delivery system for oral sustained administration of curcumin. © Pharmacotherapy Group.

Kumar K.,NIMS University | Rai A.K.,Pranveer Singh Institute of Technology
Tropical Journal of Pharmaceutical Research | Year: 2011

Purpose: To develop a proniosomal carrier system of curcumin for transdermal delivery. Methods: Proniosomes of curcumin were prepared by encapsulation of the drug in a mixture of Span 80, cholesterol and diethyl ether by ether injection method, and then investigated as a transdermal drug delivery system (TDDS). The formulated systems were characterized for size, drug entrapment, angle of repose, hydration rate and vesicular stability under various storage conditions. In vitro release studies were performed using albino rat skin. Results: The method used for preparing proniosome resulted in an encapsulation yield of 82.3 - 86.8%. Scanning electron microscopy analysis showed that the surface of the particles was smooth. Stability data following storage under different conditions showed that the drug content of the proniosomes varied from 99.5% under refrigerated condition to 99.2 and 93% at room and elevated temperatures, respectively. One of the formulations (PG1) showed prolonged in vitro drug release of 61.8% over a period of 24 h. Conclusion: It is evident from this study that proniosomes are very stable and promising prolonged delivery system for curcumin. © Pharmacotherapy Group.

Kushwaha S.K.S.,Pranveer Singh Institute of Technology | Rai A.K.,Pranveer Singh Institute of Technology | Singh S.,Saroj Institute of Technology and Management
Tropical Journal of Pharmaceutical Research | Year: 2014

Purpose: To formulate and evaluate temperature -sensitive, controlled-release camptothecin hydrogel for anticancer drug delivery. Method:Temperature-sensitive hydrogel based on chitosan/β-glycerophosphate (β-GP)/β-cyclodextrin (β-CD) was prepared by crosslinking method. The formulations were characterized by Fourier transform infrared spectroscopy (FTIR), x -ray diffraction (XRD), gelation time, and viscometry, as well as for controlled release. The formulation, containing camptothecin, was studied by MTT assay on tumor cellMCF-7. The effectiveness of treatment was measured in terms of controlled tumor growth inhibition (TGI). Results:The hydrogel formulation showed good properties in terms of pH, gelation, viscosity and invitro release. The gelation temperature and viscosity of the formulation was optimum. Camptothecin (CPT) released from the hydrogel (TF8) over 8 h in pH 7.4 buffer ranged from 38.97 -92.5%, and varied according to the composition of the hydrogels. Release of camptothecin was lowest from preparations without cyclodextrins. Tumor growth inhibition activity of CPT in MCF-7 cell was highest for the formulation containing 1% chitosan, 8% β-GP and 1% β-CD while no inhibition was observed for the blank temperature sensitive hydrogel formulation. Conclusion: These formulations are a promising and more effective delivery system that can be developed to serve as an alternative to the conventional system for anticancer drug delivery. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.

Awasthi A.K.,Pranveer Singh Institute of Technology
International Journal of Information and Computer Security | Year: 2010

In 1996, Mambo et al. introduced the proxy signature scheme for digital applications to delegate the signing capability to a proxy signer. Various constructions were made to devise a strong nondesignated proxy signature scheme. In 2002, Shum and Wei proposed an extended scheme to hide the identity of the proxy signer. A Trusted Authority (TA) can reveal the proxy signer's identity if required. In this paper we show some possible attacks on this scheme. Copyright © 2010 Inderscience Enterprises Ltd.

Kushwaha S.K.S.,Pranveer Singh Institute of Technology | Keshari R.K.,Pranveer Singh Institute of Technology | Rai A.K.,Pranveer Singh Institute of Technology
Journal of Applied Pharmaceutical Science | Year: 2011

Transmucosal nasal delivery is a promising drug delivery option where common drug administrations, such as intravenous, intramuscular, or oral are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than the oral route. This has been attributed to rich vasculature and a highly permeable structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain. Intranasal microemulsions, gels and microspheres have gained increased interest in recent years as a delivery system for protein and peptides through the nasal route. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal drug absorption mechanisms, various nasal drug delivery systems, and their applications in drug delivery.

Shahi A.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2014

Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. CNTs can be functionalized (i.e., surface engineered) with certain functional groups in order to manipulate their physical or biological properties. Carbon nanotubes (CNTs) are allotropes of carbon with a cylindrical nanostructure. CNTs made from a single graphene sheet results in a singlewalled nanotubes (SWNT) while several graphene sheets make up multiwalled carbon nanotubes (MWNTs). This paper will discuss the therapeutic applications of CNTs with a major focus on their applications for the treatment of cancer.

Tiwari G.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2010

This study reports on the development of novel biodegradable microspheres prepared by oil-in-water-oil (O/W/O) double emulsion technique using the blends of poly (D, L-lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) in different ratios for the controlled delivery of metronidazole (MTZ). Metronidazole encapsulation of up to 40% was achieved within the polymeric microspheres. Blend placebo microspheres, drug-loaded microspheres were analyzed by Fourier transform infrared spectroscopy (FT-IR), which indicated no interaction between drug and polymers. Differential scanning calorimetry (DSC) on drug-loaded microspheres confirmed the polymorphism of MTZ and indicated a molecular level dispersion of MTZ in the microspheres. Scanning electron microscopy (SEM) confirmed the spherical nature and smooth surfaces of the microspheres produced. Mean particle size of the microspheres as measured by dynamic laser light scattering method ranged between 100 and 200 μm. In vitro release studies performed in 7.4 pH media indicated the release of MTZ from 7 to 11 days, depending upon the blend ratio of the matrix. Up to 11 days, MTZ concentrations in the gingival crevicular fluid were higher than the minimum inhibitory concentration of MTZ against most of the periodontal pathogens. Statistical analyses of the release data were performed using the analysis of variance (ANOVA) method.

Tiwari G.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2010

A novel drug delivery system for the treatment of periodontitis was developed for site-specific delivery of metronidazole (MTZ) which has excellent activity against anaerobic microorganisms. The calibration curve for MTZ was developed in pH 6.6 phosphate buffer at 287.6 nm in the range of 2 to 14 μg/ml. MTZ films were prepared by solvent casting technique using ethyl cellulose and other copolymers in chloroform: dichloromethane (1:1) solvent with dibutyl phthalate and PEG 400 as plasticizers. FT-IR and UV spectroscopic methods revealed no interaction between MTZ and polymers. The films were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, tensile strength, surface pH, and in vitro antibacterial activity. In vitro release from films was fit to different equations and kinetic models to reveal release kinetics. Kinetic models were studied for zero order, first-order equations, and Hixson-Crowell and Higuchi models. Formulation F2 released 99.74% of drug at the end of tenth day and was considered as best formulation. A short-term stability study shows that drug content decreased in various films and was ranging from 0.8% to 3.02%.

Kushwaha N.,Pranveer Singh Institute of Technology | Kushwaha S.K.S.,Pranveer Singh Institute of Technology | Rai A.K.,Pranveer Singh Institute of Technology
International Journal of ChemTech Research | Year: 2012

Thiadiazole and its derivatives are important organic reaction intermediates and they have been widely used as anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, antiviral, diuretic and muscles relaxant activity. Generally, synthesis of the thiadiazole derivations needs high temperature (≥ 100°C) or low temperature (< 0°C) or high pressure (at least higher than 1 atmospheric pressure), and the yields of those reactions are low. Otherwise, they could be synthesized by reacting thiocarbonyl dichloride with dithizone. A series of thiadiazole have been synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data.

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