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Kumar K.,NIMS University | Kumar K.,Global Institute of Pharmaceutical Education and Research | Rai A.K.,Pranveer Singh Institute of Technology
Tropical Journal of Pharmaceutical Research | Year: 2012

Purpose: To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence time and increased drug bioavailability. Methods: Floating microsphere were prepared by emulsion solvent diffusion method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1. The floating microspheres were evaluated for flow properties, particle size, incorporation efficiency, as well as in-vitro floatability and drug release. The shape and surface morphology of the microspheres were characterised by optical and scanning electron microscopy. Result: The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 251 - 387 μm, 74.6 - 90.6 %, and 72.6 - 83.5 %, and 45.5 - 82.0 %, respectively. Maximum drug release after 20 h was 47.1, 55.7, 69.4 and 81.3 % for formulations F1, F2, F3 and F4, respectively. Scanning electron micrographs indicate pores both on the surface and interior of the microspheres. Conclusion: The developed curcumin microsphere system is a promising floating drug delivery system for oral sustained administration of curcumin. © Pharmacotherapy Group. Source

Awasthi A.K.,Pranveer Singh Institute of Technology
International Journal of Information and Computer Security | Year: 2010

In 1996, Mambo et al. introduced the proxy signature scheme for digital applications to delegate the signing capability to a proxy signer. Various constructions were made to devise a strong nondesignated proxy signature scheme. In 2002, Shum and Wei proposed an extended scheme to hide the identity of the proxy signer. A Trusted Authority (TA) can reveal the proxy signer's identity if required. In this paper we show some possible attacks on this scheme. Copyright © 2010 Inderscience Enterprises Ltd. Source

Jaiswal S.,Advance Institute of Biotech and Paramedical science | Mishra A.P.,Advance Institute of Biotech and Paramedical science | Srivastava A.,Pranveer Singh Institute of Technology
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Benzoheterocycles such as benzothiazoles can serve as unique and versatile scaffolds for experimental drug design. Among the all benzohaterocycles, benzothiazole has considerable place in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. The small and simple benzothiazole nucleus possesses numerous pharmacological activities like- antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. Since, a wide range of different reactions are available for synthesizing 2-substituted benzothiazole nucleus and its derivatives by using different type of catalysts but a real need exists for new procedures that support many kinds of structural diversity and various substitution. The present review focuses on the different kind of reactions involved in synthesis as well as cyclisation of benzothiazole nucleus and its derivatives. Source

Tiwari G.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2010

This study reports on the development of novel biodegradable microspheres prepared by oil-in-water-oil (O/W/O) double emulsion technique using the blends of poly (D, L-lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) in different ratios for the controlled delivery of metronidazole (MTZ). Metronidazole encapsulation of up to 40% was achieved within the polymeric microspheres. Blend placebo microspheres, drug-loaded microspheres were analyzed by Fourier transform infrared spectroscopy (FT-IR), which indicated no interaction between drug and polymers. Differential scanning calorimetry (DSC) on drug-loaded microspheres confirmed the polymorphism of MTZ and indicated a molecular level dispersion of MTZ in the microspheres. Scanning electron microscopy (SEM) confirmed the spherical nature and smooth surfaces of the microspheres produced. Mean particle size of the microspheres as measured by dynamic laser light scattering method ranged between 100 and 200 μm. In vitro release studies performed in 7.4 pH media indicated the release of MTZ from 7 to 11 days, depending upon the blend ratio of the matrix. Up to 11 days, MTZ concentrations in the gingival crevicular fluid were higher than the minimum inhibitory concentration of MTZ against most of the periodontal pathogens. Statistical analyses of the release data were performed using the analysis of variance (ANOVA) method. Source

Tiwari G.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2010

A novel drug delivery system for the treatment of periodontitis was developed for site-specific delivery of metronidazole (MTZ) which has excellent activity against anaerobic microorganisms. The calibration curve for MTZ was developed in pH 6.6 phosphate buffer at 287.6 nm in the range of 2 to 14 μg/ml. MTZ films were prepared by solvent casting technique using ethyl cellulose and other copolymers in chloroform: dichloromethane (1:1) solvent with dibutyl phthalate and PEG 400 as plasticizers. FT-IR and UV spectroscopic methods revealed no interaction between MTZ and polymers. The films were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, tensile strength, surface pH, and in vitro antibacterial activity. In vitro release from films was fit to different equations and kinetic models to reveal release kinetics. Kinetic models were studied for zero order, first-order equations, and Hixson-Crowell and Higuchi models. Formulation F2 released 99.74% of drug at the end of tenth day and was considered as best formulation. A short-term stability study shows that drug content decreased in various films and was ranging from 0.8% to 3.02%. Source

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