Pranveer Singh Institute of Technology

Kānpur, India

Pranveer Singh Institute of Technology

Kānpur, India
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Saxenaa P.,Pranveer Singh Institute of Technology | Kushwaha S.K.S.,Pranveer Singh Institute of Technology
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective- The prolonged retention of drug formulation in the eye is of utmost importance for topical ophthalmic drug delivery. The objective of the present investigation is to develop mucoadhesive Temperature Sensitive Ophthalmic Gels of Levofloxacin hemihydrate, a Fluoroquinolone antibiotic drug with enhanced solubility and prolonged retention time in order to improve the bioavailability of drug. Methods- The gelation upon contact with conjuctival membrane was conferred via the use of the Thermogelling Poloxamer 407 whereas mucoadhesion and drug release enhancement were modulated via the use of mucoadhesive and polyethylene glycol (PEG) polymers respectively. β-Cyclodextrin in 0.2% concentration was used to increase the solubility of Levofloxacin. Results- The results revealed that the different Mucoadhesives augmented the retention time but extensively increased the viscosity of formulations due to which the formulations were too viscous to be instilled and may cause blurring of vision after instillation. The inclusion of PEG counteracted the effect of the mucoadhesive polymers whereby it decreased the viscosity to desired level and increased the in vitro drug release. The formulations with favorable sol-gel transition temperatures (35-37°C), Viscosity and high in vitro drug release were also therapeutically efficacious, sterile, stable, non irritant and rheologically stable upon storage. Formulations provided sustained release of the drug over a period of 6 h. Conclusion- The study points to the potential of Temperature Sensitive Ophthalmic Gels in terms of ease of administration, accuracy of dosing, prolonged retention and improved drug bioavailability.

Kumar K.,NIMS University | Kumar K.,Global Institute of Pharmaceutical Education and Research | Rai A.K.,Pranveer Singh Institute of Technology
Pharmazie | Year: 2012

Curcumin, the active ingredient of the spice turmeric, has a long history as an herbal remedy for a variety of diseases. Transdermal drug delivery has been recognized as an alternative route to oral delivery. Proniosomes offer a versatile vesicle delivery concept with the potential for drug delivery via the transdermal route. In this study, different proniosomal gel bases were prepared by the ether injection method, using Span 60 and Span 80, Tween 20, cholesterol, and formulation PA2. They were characterized by scanning electron microscopy, revealing vesicular structures, and assessed for stability and effect on in vitro skin permeation using rat skin. Anti-inflammatory and anti-arthritic effects of formulation PA2 and PB1 were compared with a standard market product containing indomethacin. The effect of formulation PA2 and PB1 was evaluated for acute inflammation in carrageenan induced rat paw edema and for chronic inflammation in complete Freud's adjuvant (CFA) induced arthritis in rats. Further histopathological and radiographic evaluation was performed. The investigated curcumin loaded proniosomal formula proved to be non-irritant, non-toxic, but had lower anti-inflammatory and anti-arthritic effects than the marketed indomethacin products.

Maheshwari N.,Pranveer Singh Institute of Technology
International Journal of Drug Development and Research | Year: 2013

This work is concerned with application of simple, economical, precise, accurate and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Valsartan potassium (VP) and Amlodipine besylate (AB) on RP C-18 Column (Inertsil ODS-2, 150 × 4.6 mm) using Methanol: Water (62:38), pH adjusted to 3.0 with O-phosphoric acid as mobile phase at a flow rate of 1.4 ml/min and the detection wavelength was 230 nm. The retention time for VP and AB was found to be 6.0 and 3.5 min, respectively. Proposed method was validated for precision, accuracy, linearity range, robustness and ruggedness. © 2013 Nitesh Maheshwari et al, publisher and licensee IYPF.

Kumar R.,Pranveer Singh Institute of Technology | Yar M.S.,Jamia Hamdard University | Chaturvedi S.,Jamia Hamdard University | Srivastava A.,Jamia Hamdard University
International Journal of PharmTech Research | Year: 2013

In the previous years the synthesis of high nitrogen containing heterocyclic systems has been attracted to many pharmaceutical and agrochemical industries. The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics are found in abundance in most of the medicinal compounds. The triazoles are said to be the isosters of imidazoles in which the carbon atom of imidazole is isosterically replaced by nitrogen. Triazole & its derivatives have a wide range of application. They are predominantly among the type of compounds used such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antihypertensive, antimalarial, antianxiety, antidepressant, and antihistaminic, antitubercular agents etc. The derivatization of Triazole ring is based on the phenomenon of bioisosterism in which replacement of oxygen of oxadiazole nucleus with nitrogen triazole analogue.

Kumar K.,NIMS University | Rai A.K.,Pranveer Singh Institute of Technology
Tropical Journal of Pharmaceutical Research | Year: 2011

Purpose: To develop a proniosomal carrier system of curcumin for transdermal delivery. Methods: Proniosomes of curcumin were prepared by encapsulation of the drug in a mixture of Span 80, cholesterol and diethyl ether by ether injection method, and then investigated as a transdermal drug delivery system (TDDS). The formulated systems were characterized for size, drug entrapment, angle of repose, hydration rate and vesicular stability under various storage conditions. In vitro release studies were performed using albino rat skin. Results: The method used for preparing proniosome resulted in an encapsulation yield of 82.3 - 86.8%. Scanning electron microscopy analysis showed that the surface of the particles was smooth. Stability data following storage under different conditions showed that the drug content of the proniosomes varied from 99.5% under refrigerated condition to 99.2 and 93% at room and elevated temperatures, respectively. One of the formulations (PG1) showed prolonged in vitro drug release of 61.8% over a period of 24 h. Conclusion: It is evident from this study that proniosomes are very stable and promising prolonged delivery system for curcumin. © Pharmacotherapy Group.

Kushwaha S.K.S.,Pranveer Singh Institute of Technology | Keshari R.K.,Pranveer Singh Institute of Technology | Rai A.K.,Pranveer Singh Institute of Technology
Journal of Applied Pharmaceutical Science | Year: 2011

Transmucosal nasal delivery is a promising drug delivery option where common drug administrations, such as intravenous, intramuscular, or oral are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than the oral route. This has been attributed to rich vasculature and a highly permeable structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain. Intranasal microemulsions, gels and microspheres have gained increased interest in recent years as a delivery system for protein and peptides through the nasal route. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal drug absorption mechanisms, various nasal drug delivery systems, and their applications in drug delivery.

Shahi A.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2014

Carbon nanotubes (CNTs) have been introduced recently as a novel carrier system for both small and large therapeutic molecules. CNTs can be functionalized (i.e., surface engineered) with certain functional groups in order to manipulate their physical or biological properties. Carbon nanotubes (CNTs) are allotropes of carbon with a cylindrical nanostructure. CNTs made from a single graphene sheet results in a singlewalled nanotubes (SWNT) while several graphene sheets make up multiwalled carbon nanotubes (MWNTs). This paper will discuss the therapeutic applications of CNTs with a major focus on their applications for the treatment of cancer.

Tiwari G.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2010

This study reports on the development of novel biodegradable microspheres prepared by oil-in-water-oil (O/W/O) double emulsion technique using the blends of poly (D, L-lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) in different ratios for the controlled delivery of metronidazole (MTZ). Metronidazole encapsulation of up to 40% was achieved within the polymeric microspheres. Blend placebo microspheres, drug-loaded microspheres were analyzed by Fourier transform infrared spectroscopy (FT-IR), which indicated no interaction between drug and polymers. Differential scanning calorimetry (DSC) on drug-loaded microspheres confirmed the polymorphism of MTZ and indicated a molecular level dispersion of MTZ in the microspheres. Scanning electron microscopy (SEM) confirmed the spherical nature and smooth surfaces of the microspheres produced. Mean particle size of the microspheres as measured by dynamic laser light scattering method ranged between 100 and 200 μm. In vitro release studies performed in 7.4 pH media indicated the release of MTZ from 7 to 11 days, depending upon the blend ratio of the matrix. Up to 11 days, MTZ concentrations in the gingival crevicular fluid were higher than the minimum inhibitory concentration of MTZ against most of the periodontal pathogens. Statistical analyses of the release data were performed using the analysis of variance (ANOVA) method.

Tiwari G.,Pranveer Singh Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2010

A novel drug delivery system for the treatment of periodontitis was developed for site-specific delivery of metronidazole (MTZ) which has excellent activity against anaerobic microorganisms. The calibration curve for MTZ was developed in pH 6.6 phosphate buffer at 287.6 nm in the range of 2 to 14 μg/ml. MTZ films were prepared by solvent casting technique using ethyl cellulose and other copolymers in chloroform: dichloromethane (1:1) solvent with dibutyl phthalate and PEG 400 as plasticizers. FT-IR and UV spectroscopic methods revealed no interaction between MTZ and polymers. The films were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, tensile strength, surface pH, and in vitro antibacterial activity. In vitro release from films was fit to different equations and kinetic models to reveal release kinetics. Kinetic models were studied for zero order, first-order equations, and Hixson-Crowell and Higuchi models. Formulation F2 released 99.74% of drug at the end of tenth day and was considered as best formulation. A short-term stability study shows that drug content decreased in various films and was ranging from 0.8% to 3.02%.

Kushwaha N.,Pranveer Singh Institute of Technology | Kushwaha S.K.S.,Pranveer Singh Institute of Technology | Rai A.K.,Pranveer Singh Institute of Technology
International Journal of ChemTech Research | Year: 2012

Thiadiazole and its derivatives are important organic reaction intermediates and they have been widely used as anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, antiviral, diuretic and muscles relaxant activity. Generally, synthesis of the thiadiazole derivations needs high temperature (≥ 100°C) or low temperature (< 0°C) or high pressure (at least higher than 1 atmospheric pressure), and the yields of those reactions are low. Otherwise, they could be synthesized by reacting thiocarbonyl dichloride with dithizone. A series of thiadiazole have been synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data.

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