Placido de Castro, Brazil
Placido de Castro, Brazil

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Fernandes J.V.,Federal University of Rio Grande do Norte | Fernandes T.A.A.M.,Grande Rio University | de Azevedo J.C.V.,University Hospital Onofre Lopes | Cobucci R.N.O.,Federal University of Rio Grande do Norte | And 3 more authors.
Oncology Letters | Year: 2015

Inflammation is a defense strategy against invading agents and harmful molecules that is activated immediately following a stimulus, and involves the release of cytokines and chemokines, which activate the innate immune response. These mediators act together to increase blood flow and vascular permeability, facilitating recruitment of effector cells to the site of injury. Following resolution of the injury and removal of the stimulus, inflammation is disabled, but if the stimulus persists, inflammation becomes chronic and is strongly associated with cancer. This is likely to be due to the fact that the inflammation leads to a wound that does not heal, requiring a constant renewal of cells, which increases the risk of neoplastic transformation. Debris from phagocytosis, including the reactive species of oxygen and nitrogen that cause damage to DNA already damaged by the leukotrienes and prostaglandins, has an impact on inflammation and various carcinogenic routes. There is an association between chronic inflammation, persistent infection and cancer, where oncogenic action is mediated by autocrine and paracrine signals, causing changes in somatic cells under the influence of the microbial genome or of epigenetic factors. Among the infectious agents associated with cancer, certain genotypes of human papillomavirus (HPV) stand out. HPV is responsible for virtually all cases of cervical cancer and a lower proportion of cancers of the vagina, vulva, anus, penis and a number of extragenital cancers. In the present review, recent advances in the mechanisms involved in the inflammatory response are presented with their participation in the process of carcinogenesis, emphasizing the role of chronic inflammation in the development of HPV-induced cervical cancer. © 2015, Spandidos Publications. All rights received.


Elsangedy H.M.,Potiguar University | Krause M.P.,Federal University of Paraná | Krinski K.,Federal University of Paraná | Alves R.C.,Federal University of Paraná | And 2 more authors.
Journal of Strength and Conditioning Research | Year: 2013

The purpose of this study was to verify the self-selected intensity during resistance training (RT) in older women. Twenty healthy women (mean age, 65.6 years) underwent a 2-week familiarization period followed by 3 experimental sessions. During the first session, anthropometric measurements were taken. The second session involved completion of a 1 repetition maximum (1RM) test for the following exercises: chest press, leg press, lat pull-down, leg extension, lateral shoulder raise, leg curl, biceps curl, and triceps pushdown. Last, a single RT session was performed at a self-selected intensity. During the RT session, participants were instructed to self-select a load for performing 3 sets of 10-15 repetitions. Data were analyzed by mean (SD) and analysis of variance with repeated measures (p < 0.05). Global mean of the 3 sets was bench press 41.0% 1RM (11.9), leg press 43.0% 1RM (17.2), lat pull-down 47.2% 1RM (11.1), leg extension 33.0% 1RM (8.1), lateral shoulder raise 51.1% 1RM (12.1), leg curl 43.5% 1RM (8.8), biceps curl 48.0% 1RM (15.5), and triceps pushdown 51.7% 1RM (13.3); there were no significant differences between the sets (p > 0.05). These results indicate that inactive older women self-selected an intensity exercise during RT below the recommendation for improvements on muscle fitness in apparently healthy older adults. However, this intensity is recommended for very deconditioned individuals. Nevertheless, the use of self-selection strategy during an exercise program can have greater advantages because of its easy applicability, its positive relation with exercise adherence, and for promoting initial muscle conditioning in older adults. Furthermore, it is crucial to gradually increase the RT load to guarantee better and sustainable effects on muscle fitness. Finally, future studies are needed to establish the chronic effects of RT at self-selected intensity on muscle fitness and the functional health of older adults. © 2013 National Strength and Conditioning Association.


Severo E.A.,Potiguar University | De Guimaraes J.C.F.,Potiguar University | Dorion E.C.H.,University of Caxias do Sul | Nodari C.H.,University of Caxias do Sul
Journal of Cleaner Production | Year: 2015

Abstract As a result of globalization and industrial development, concerns about pollution and the environment encompass a global level, considering that any environmental degradation can undermine an entire local ecosystem and may generate negative impacts on different biomass. Accordingly, organizations can minimize their environmental impact, by making use of environmental practices such as methodologies on cleaner production. The Automotive Metal-Mechanic Cluster of Serra Gaúcha, Brazil, is known as an important industrial Pole in Brazil, due to its high concentration of spare parts, agricultural machinery and transport vehicles production companies. This Cluster is currently the second largest of its kind in Brazil. Therefore, this study aimed to analyze the relationship between the concepts of cleaner production, environmental sustainability and organizational performance in 298 companies of the Serra Gaúcha Cluster. A survey was realized and Structural Equation Modeling was implemented for data analysis. The results show that those Serra Gaúcha companies seek alternative processes to reduce costs and contribute to the company's image for their customers. It was also observed that Cleaner Production practices influence environmental sustainability, as well as organizational performance; showing that cleaner production methodologies contribute to increase production capacity and flexibility and improve aspects of health and safety. Finally, it is worth noting that companies in the Serra Gaúcha tend to become committed to environmental sustainability, to the welfare of their workers, to society and its environment; adapting to such reality either by coercive and normative pressures. © 2014 Elsevier Ltd. All rights reserved.


Neto A.R.V.,Potiguar University | de Melo L.G.N.S.,Potiguar University
Saude e Sociedade | Year: 2013

Food choice in contemporary societies is, inevitably, a buying decision. Food is a product that is consumed, like so many other goods and services. Nowadays many children choose their food themselves, which attracts attention not only from companies that develop products and advertising for that segment, but also organizations concerned with their nutrition. This paper analyzed the factors that influence children's food purchasing behavior using the Perpective Behavioral Model (BPM) created by Foxall (2010), which in turn is based on consumer psychology and structured on Skinner's triple contingency. The subjects were 175 students between 10 and 12 years old. Thirty-five variables were identified and classified as antecedent stimuli (setting or learning history) or purchase reinforcers (utilitarian or informational reinforcement). It was seen that reinforcement stimuli (consequent stimuli) are more important to these children's decisions than antecedent stimuli, and that utilitarian consequences are more influential than informational consequences. It was concluded that product attributes such as taste and quality have greater influence on purchasing decisions than environmental stimuli such as promotions and food advertising.


Objective: To reflect on work processes in the primary care network of the SUS (Brazil's National Health System), focusing on the care practices in mental health. Methodology: Interviews with 12 workers of the Family Health Strategy: physicians, nurses and community health agents; participant observation of the daily routine of the Family Health Unit; home visits. Results: The work processes in health are bureaucratically and hierarchically organized and the care practices scrutinize users based on the knowledge/action of each professional category. The specialism logic is recurrent and the teams, in general, do not receive the users well, do not attend to the demands and end up referring users to other units. Conclusion: We believe that with a new work and management arrangement mode it is possible to interfere in the subjectivity and in the culture that prevails among the health workers, intensify the therapeutic bond and the intersection between knowledge and practices, and produce work processes that result in receptivity and responsibility for the user's life.


Clemente H.A.,Federal University of Rio Grande do Norte | Ramalho H.M.M.,Potiguar University | Lima M.S.R.,Federal University of Rio Grande do Norte | Grilo E.C.,Federal University of Rio Grande do Norte | Dimenstein R.,Federal University of Rio Grande do Norte
Journal of Pediatric Gastroenterology and Nutrition | Year: 2015

Objectives: Newborns are considered a high-risk group for vitamin E deficiency. Breast milk is a source of alpha-tocopherol (α-TOH), a form of vitamin E that prevents deficiency. The present study aimed to assess whether supplementation with a natural or synthetic form of α-TOH, in addition to maternal sources of vitamin E, would increase the concentration of α-TOH in colostrum. Methods: A total of 109 healthy lactating women were recruited from a Brazilian public maternity clinic and randomized into 3 groups: control without supplementation (n=36), natural α-TOH supplementation (n=40), and synthetic α-TOH supplementation (n=33). Blood and colostrum samples were collected before and after supplementation to check the nutritional status of these women by high-performance liquid chromatography. The Kruskal-Wallis test was applied for independent samples, and Tukey test was used for 2-way analysis of the averages of the groups. The baseline nutritional status of vitamin E of all of the lactating women enrolled in the trial was considered adequate. Results: Women who received supplementation had higher concentrations of α-TOH in colostrum than the control group, with 57% and 39% increases in women supplemented with the natural and synthetic forms of α-TOH, respectively. Conclusions: Supplementation with both forms of α-TOH increased vitamin E concentrations in colostrum; however, the natural form was more efficient in increasing the levels. © Copyright 2015 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.


Da Costa Evangelista J.P.,Potiguar University | Gondim A.D.,Federal University of Rio Grande do Norte | Souza L.D.,State University of Rio Grande do Norte | Araujo A.S.,Federal University of Rio Grande do Norte
Renewable and Sustainable Energy Reviews | Year: 2016

Alumina-supported potassium oxides are promising catalysts for the transesterification reaction of vegetable oils for biodiesel production. Various potassium compounds Al2O3-supported were prepared via impregnation method. Potassium oxide (K2O) is a good candidate for a solid base catalyst from an economical point of view. In the present work, we reviewed K2O catalyst for the vegetable oil transesterification based on a variety of related research papers. The potassium compounds supported in catalysts, KOH/Al2O3, KNO3/Al2O3, KI/Al2O3, KF/Al2O3 and K2CO3/Al2O3, were optimized through various reaction parameters, such as: amount of catalyst, molar ratio of oil to alcohol, reaction time and temperature. Yields and conversions from various catalytic systems applied for biodiesel production were also compared. Among the catalysts studied, the KF/Al2O3 showed higher catalytic activity and a small amount of catalyst requirement in the transesterification reaction, indicating that it can be applied as a potential catalyst in the industry. © 2016 Elsevier Ltd.


de Attayde Silva M.J.P.M.,Potiguar University | Dantas Florencio G.L.,Federal University of Rio Grande do Norte | Erbolato Gabiatti J.R.,University of Medical Sciences of Costa Rica | do Amaral R.L.,University of Campinas | And 2 more authors.
Brazilian Journal of Infectious Diseases | Year: 2011

Objective: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. Methods: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. Results: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively). Conclusion: The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings. © 2011 Elsevier Editora Ltda.


Dantas A.N.,Potiguar University | de Morais E.F.,Potiguar University | de Paiva Macedo R.A.,Potiguar University | de Lima Tinoco J.M.,Potiguar University | And 3 more authors.
Brazilian Journal of Otorhinolaryngology | Year: 2015

Introduction: Adenoid cystic carcinoma is the most frequent malignant tumor of the submandibular gland and the minor salivary glands. It is a malignant neoplasm that, despite its slow growth, shows an unfavorable prognosis. Objectives: The aim of this study was to perform a systematic review of the literature on Adenoid cystic carcinoma in the head and neck region and its clinicopathological characteristics, with emphasis on the perineural invasion capacity of the tumor. Methods: A systematic search of articles published between January 2000 and January 2014 was performed in the PubMed/MEDLINE, SciELO, Science Direct, and Scopus databases. Results: Nine articles were selected for this systematic review. These demonstrated that the female gender was more often affected and that malignant tumors showed a high rate of distant metastasis, recurrence, and a low survival rate. The presence of perineural invasion ranged from 29.4% to 62.5% and was associated with local tumor recurrence. Conclusion: Adenoid cystic carcinoma is commonly characterized by the presence of pain, high rate of recurrence, metastasis, and a low survival rate. Reporting studies with patient follow-up is of utmost importance for a better clinical-pathological understanding and to improve the prognosis of this pathology. Introdução: O carcinoma adenoide cístico (CAC) é o tumor maligno mais frequente da glândula Submandibular e das glândulas salivares menores. Sendo uma neoplasia maligna, apesar de ter crescimento lento, apresenta um prognóstico desfavorável. Objetivos: O objetivo deste trabalho foi realizar uma revisão sistemática de literatura sobre o carcinoma adenóide cístico na região de cabeça e pescoço e suas características clínico-patológicas com ênfase na capacidade de infiltração perineural do tumor. Método: Uma busca sistemática de artigos publicados entre janeiro de 2000 a janeiro de 2014 foi executada nas bases de dados PubMed/MEDLINE, SciELO, Science Direct e Scopus. Resultados: Nove artigos foram selecionados para realização da revisão sistemática. Nestes, o sexo feminino foi o mais afetado e o tumor maligno apresentou uma alta taxa de metástase a distância, recidiva e baixa taxa de sobrevida. A presença de invasão perineural variou entre 29,4% a 62,5% e foi relacionada à recidiva local do tumor. Conclusão: O CAC é comumente caracterizado pela presença de dor, alta taxa de recidiva, metástase e baixa sobrevida. A realização de estudos com acompanhamento dos pacientes é de extrema importância para uma melhor avaliação clinico-patológica visando melhorar o prognóstico da doença. © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.


Raposo A.K.,Potiguar University
International journal of orthodontics (Milwaukee, Wis.) | Year: 2011

This study verified whether an IMPA above the normative value could be a sign of reduced lower incisor labial bone height. Such association, which could improve the quality of treatment planning, was not confirmed. A cone-beam CT is still recommended when a more precise diagnosis is needed.

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