Landsberg am Lech, Germany
Landsberg am Lech, Germany

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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-26-2016 | Award Amount: 10.76M | Year: 2016

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe development of nano-enabled products particularly challenging. At the heart of the challenge lies the difficulty in the reliable and reproducible characterisation of NMs given their extreme diversity and dynamic nature, particularly in complex environments, such as within different biological, environmental and technological compartments. Two key steps can resolve this: 1) the development of a holistic framework for reproducible NM characterisation, spanning from initial needs assessment through method selection to data interpretation and storage; and 2) the embedding of this framework in an operational, linked-up ontological regime to allow identification of causal relationships between NMs properties, be they intrinsic, extrinsic or calculated, and biological, (eco)toxicological and health impacts fully embedded in a mechanistic risk assessment framework. ACEnano was conceived in response to the NMBP 26 call with the aim to comprehensively address these two steps. More specifically ACEnano will introduce confidence, adaptability and clarity into NM risk assessment by developing a widely implementable and robust tiered approach to NM physico-chemical characterisation that will simplify and facilitate contextual (hazard or exposure) description and its transcription into a reliable NMs grouping framework. This will be achieved by the creation of a conceptual toolbox that will facilitate decision-making in choice of techniques and SOPs, linked to a characterisation ontology framework for grouping and risk assessment and a supporting data management system.


Patent
Postnova Analytics GmbH | Date: 2012-10-18

An apparatus for measuring the light scattering properties of a sample in a liquid medium, wherein the liquid medium with the sample is illuminated by a laser beam in a measuring cell transversely to the direction of filling the liquid medium in the measuring cell or transversely to the flow direction of the liquid medium within the measuring cell, comprising a laser, a cylindrical measuring cell, a first inner aperture system, a second outer aperture system and at least two detectors, wherein the detectors are arranged outside of the second outer aperture system so that they collect the light scattered on the sample within set, different angle ranges, wherein the first inner aperture system and the second outer aperture system are formed and arranged circularly and concentrically around the axis of the measuring cell. Use of the apparatus and a method that makes use of the apparatus are also disclosed.


The current invention relates to an apparatus for performing a centrifugal field-flow fractionation. A field-flow fractionation channel is disposed on a holder which is releasably attachable to the inner circumference of a rim of a rotor, the holder having a shape of an annulus comprising an interrupted segment. A wedge (18) which is configured to be inserted into the interrupted segment and which is wedged into the interrupted segment so as to force the holder and the channel against the inner circumference of the rim is comprised within the apparatus. The wedge has a pair of generally opposed surfaces (94) which are oriented with respect to each other so that in the inserted position of the wedge, both surfaces extend along the radial direction of the holder and are inclined relative to the axial direction of the annulus defining the holder.


The current invention relates to an apparatus for performing a centrifugal field-flow fractionation. In particular, in the apparatus according to the invention, radial rotary shaft seals are used for sealing the rotating parts of the shaft for carrying out the centrifugal field-flow fractionation and the stationary parts. Furthermore, a separate line is introduced for reducing the pressure differential across these seals. In such way, the driving force driving sample fluid across the seals is reduced, thereby reducing leakage.


The invention provides a method for measuring light scattered on a sample in a medium, in particular a fluid medium, that comprises the following steps: providing a rotatably arranged measuring cell with a substantially circular cross-section in a plane perpendicular to the axis of rotation for receiving the medium and the sample, rotating the measuring cell, preferably at least once by substantially 360, about the axis of rotation, in particular by means of a drive, emitting a laser beam by means of a laser onto the sample located within the measuring cell in the plane perpendicular to the axis of rotation at different angles of rotation of the measuring cell, the measuring cell maintaining its position in the direction of the axis of rotation, detecting scattered light signals by means of at least two detectors arranged in a circle and concentrically to the centre of rotation of the measuring cell and fixed within set, different angular ranges at different angles of rotation of the measuring cell, and determining a corrected signal value for each detector on the basis of the scattered light signals detected at different angles of rotation of the measuring cell for each detector. Furthermore, the invention provides an apparatus for measuring light scattered on a sample according to the method comprising a laser, a measuring cell and a detector.


The present invention relates to an apparatus (10) for performing a centrifugal field-flow fractionation having a rotor (10a) rotatable about a shaft (61) by a driving means, the shaft being supported at either end by a support (24a/b). The driving means comprises a DC electric motor, and the shaft is rotatably supported by a radial roller bearing (34a/b) positioned between the shaft and the support. Each of the bearings is mounted in a support. One of the bearings is axially fixed both with respect to the support and with respect to the shaft, the other being axially fixed with respect to the support only. Each of the bearings is arranged to support a load in both axial directions. The roller elements are made of a different material than the inner and outer raceways of the bearing. Further, the bearings are non-lubricated.


Patent
Postnova Analytics GmbH | Date: 2016-02-12

The present invention relates to an apparatus for field-flow fractionation and to a method for separating samples by means of field-flow fractionation using this apparatus. The apparatuses of the invention comprise a separation channel which, in addition to a first outlet for sample-containing solvent, comprises a second outlet for sample-free solvent, wherein the second outlet is arranged in a region of the separation channel from which sample-free solvent may be removed during elution and a flow volume control device is arranged downstream of the second outlet. They are characterized in that the flow volume control device is a mass flow controller.


The current invention relates to a rotor for a centrifugal field-flow fractionation apparatus comprising a field-flow fraction channel. Crucially, the field flow fractionation channel is formed by two laminar spacers and a laminar foil (78) which is tightly sandwiched between the two spacers. The laminar foil defines in the sandwiched condition the height of the channel. A recess (80) is provided in the foil, the recess defining the other dimensions of the channel. The laminar foil is made of a resilient synthetic material. The channel is sealed by means of a surface contact between the two opposite faces of the laminar foil and the sandwiching spacers.


Patent
Postnova Analytics GmbH | Date: 2015-07-10

The present invention relates to an apparatus for field-flow fractionation and to a method for separating samples by means of field-flow fractionation using this apparatus. The apparatuses of the invention comprise one or more reservoirs, a pump, a first flow volume splitting device, two valves for flow control, an injector, a separation channel having a first connector at a first end and a second connector at a second end or an AF4 separation channel having a first connector at a first end, a second connector at a second end and a third connector between the first and the second ends, optionally a second flow volume splitting device, a back-pressure element, one or more detector(s), a flow volume control device and one or more waste container(s). The apparatuses of the invention are characterized in that they comprise a valve for flow control in a first flow path and a second flow path which connect the pump to the first or the second or the third connector of the separation channel and that these valves are switched alternately in a controllable time ratio.


The current invention relates to an apparatus for performing a centrifugal field-flow fractionation. In particular, in the apparatus according to the invention, radial rotary shaft seals (36a/b) are used for sealing the rotating parts of the shaft (61) for carrying out the centrifugal field-flow fractionation and the stationary parts. Furthermore, a separate line is introduced for reducing the pressure differential across these seals. In such way, the driving force driving sample fluid across the seals is reduced, thereby reducing leakage.

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