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Mahajan N.,Maharashtra Institute of Pharmacy | Sakarkar D.,Maharashtra Institute of Pharmacy | Manmode A.,Astron Research Ltd | Pathak V.,Post Graduate Institute of Veterinary and Animal science | And 2 more authors.
Advanced Science Letters | Year: 2011

Nanoparticles (NPs) are proposed for targeted drug delivery to the inflammation site in severe cases of inflammatory bowel disease (IBD) where state-of-the-art delivery devices fail. Meselamine (5-Aminosalicylic acid), entrapped into nanoparticles was administered either orally or rectally to male Wistar rats suffering from a preexisting experimental colitis induced by acetic acid. Meselamine, a front line drug in the treatment of ulcerative colitis, was incorporated within poly(lactic-co-glycolic acid) i.e., PLGA nanoparticles, which were administered once a day orally and rectally for five consecutive days. Clinical activity score, colon/body weight ratio, ulcer index and myeloperoxidase activity were determined to assess the inflammation. All nanoparticulate formulations proved to be efficient as compared to the free drug in suspension in mitigating the experimental colitis. The clinical activity score, myeloperoxidase activity and ulcer index decreased significantly (p<0.05*), after the oral administration of meselamine nanoparticles suspension. The free drug, meselamine, suspension does not found effective in terms of clinical activity, myeloperoxidase activity and ulcer index, as is evident from the nonsignificant decrease in clinical parameters. The meselamine nanoparticles proved their potential to retain the drug from systemic absorption as evident by a significantly reduced clinical activity, myeloperoxidase activity and ulcer index. The nanoparticles potential in reducing the inflammation was further proved by the histopathology of the resected colon from every group of animals. The use of drug loaded nanoparticles offers several advantages compared to standard therapeutic strategies such as a higher selectivity in adhesion to and enhanced drug penetration into the inflamed tissue. © 2011 American Scientific Publishers. Source


Kharkar K.,Post Graduate Institute of Veterinary and Animal science | Kharkar K.,Nagpur Veterinary College | Kuralkar S.V.,Post Graduate Institute of Veterinary and Animal science | Hadge M.R.,Post Graduate Institute of Veterinary and Animal science
Indian Journal of Animal Research | Year: 2015

The data on 481 lactation records including 204 records of Red Kandhari cows and 277 records of Jersey x Red Kandhari crossbred cows were collected from Cattle Unit, College of Veterinary and Animal Sciences, (MAFSU), Parbhani over a period of 27 years (1977-2004). The lactation milk yield for first, second, third, fourth and fifth and above lactations for Red Kandhari cows were 375.16±34.15 kg, 458.17±37.62 kg, 450.91±26.74 kg, 532.69±67.74 kg and 674.29±82.09 kg, respectively and for Jersey x Red Kandhari crossbred were 1100.28±73.18 Kg, 1318.50±135.20 Kg and 1353.92±91.61 Kg, 1549.77±188.47 kg and 1438.37±48.89 kg, respectively. The first lactation length and first dry period in Red Kandhari cows were 273.30±10.33 days and 239.05±21.88 days, while in Jersey x Red Kandhari crossbred cows were 302.68±9.19 days and 86.72±8.90 days, respectively. The least square analysis of variance for first, second and third and more than three lactations for lactation milk yield, lactation length and dry period showed that the genetic group had significant source of variation for all traits in all lactations except first and second lactation length. Sire within genetic group had significant source of variation for first lactation milk yield and all traits of third and more than three lactations. Season and period of calving had non-significant influence on all the traits in all lactations except first dry period. It was also observed that the improved performance in all the traits under study in Red Kandhari cow and Jersey x Red Kandhari crossbred cow was observed in fourth and fifth and above lactations. © 2015, Agricultural Research Communication Centre. All rights reserved. Source


Sahatpure S.K.,Post Graduate Institute of Veterinary and Animal science | Pawshe C.H.,Post Graduate Institute of Veterinary and Animal science | Ninawe A.S.,Post Graduate Institute of Veterinary and Animal science
Revista Veterinaria | Year: 2010

There is paucity of information concerning the aspiration vacuum which is inconsistent. To date, the aspiration vacuum has usually been expressed in millimeter of mercury and has varied between 40 to 400 mmHg. However, the exact aspiration vacuum at the top of the needle depends on the construction of the ovum pick up device, the length and the diameter of the tubing system and the diameter of the needle. To study the effect of vacuum pressure on recovery rate and quality of oocytes three different aspiration vacuum pressures (80, 90 and 100 mmHg) were applied. In the present study, the total 36 sessions were carried out in which total 134 animals were aspirated by using three different vacuum pressure (80, 90 and 100). By using 80-mmHg vacuum pressures, total 24 animals were aspirated in 7 sessions, in which total 59 follicles (2.46 follicles/animal and 8.43 follicles/session) were aspirated. The mean number of large, medium and small follicles were 2.29, 3.71 and 2.43, respectively. The total 32 oocytes (1.33 oocytes/animal and 4.57 oocytes/session) were collected, in which the mean number of A, B, C and D quality oocytes were 1.85, 1.00, 1.57 and 0.14, respectively. The average oocytes recovery by using 80-mmHg vacuum pressures was 54.23%. By using 90-mmHg vacuum pressures, total 90 animals were aspirated in 23 sessions, in which total 262 follicles (2.91 follicles/animal and 11.39 follicles/session) were aspirated. The mean number of large, medium and small follicles were 2.74, 5.09 and 3.57, respectively. The total 182 oocytes (2.02 oocytes/animal and 7.91 oocytes/session) were collected, in which the mean number of A, B, C and D quality oocytes were 2.61, 1.96, 1.65 and 1.67, respectively. The average oocytes recovery by using 90mmHg was 69.46 %. By using 100-mmHg, total 20 animals were aspirated in 6 sessions, in which total 58 follicles (2.90 follicles/animal and 9.67 follicles/session) were aspirated. The mean number of large, medium and small follicles were 2.83, 3.83 and 3.00, respectively. The total 37 oocytes (1.85 oocytes/animal and 6.16 oocytes/session) were collected, in which the mean number of A, B, C and D quality oocytes were 2.00, 1.33, 1.50 and 1.33, respectively. The average oocytes recovery by using 100 mmHg was 63.79%. The results revealed that by using 90mmHg vacuum pressure, 11.39 follicles/session were aspirated. In which, average 7.91 oocytes/session were collected, so the total oocyte recovery rate was 69.46%, was better than 80 and 90 mm Hg vacuum pressure, having 54.23% and 63.79% oocytes recovery, respectively. Source


Kuralkar S.V.,Post Graduate Institute of Veterinary and Animal science | Bankar P.S.,Post Graduate Institute of Veterinary and Animal science | Kuralkar P.,Post Graduate Institute of Veterinary and Animal science
Indian Journal of Animal Sciences | Year: 2014

An attempt was made to envisage physical characteristics, production and reproduction performance of Deoni, a medium size dual purpose indigenous breed of cattle in Maharashtra in its home tract. Chest girth, body length, height at wither, long horn, ear length and face length were measured. The mean values for age at first mating, age at first calving, service period and calving interval were 35.45±0.30 months, 44.50±0.30 months, 116.04±3.21 days and 395.87±3.38 days, respectively. Source


Deshmukh S.G.,Post Graduate Institute of Veterinary and Animal science | Pawshe C.H.,Post Graduate Institute of Veterinary and Animal science | Sahatpure S.K.,Post Graduate Institute of Veterinary and Animal science | Patil R.K.,Post Graduate Institute of Veterinary and Animal science
Indian Journal of Animal Sciences | Year: 2010

Cyclic cows (7) were divided into 2 different treatment groups for superovulation. Group 1 (n=4) cows were treated with follitropin-V (400 mg) subcutaneously diluted in 3.2% gelatin carrier vehicle in descending doses and group 2 (n=3) cows were treated with follitropin-V (400 mg) intramuscularly twice daily in descending doses. AU the animals (1.00%) exhibited, superovulatory estrus. The average time required for onset of estrus was 39.5±6.65 h and. 27.33± 10.53 h and the duration of superovulatory estrus was 27.5±9.16 and 26.5±8.81 h in group 1 and 2, respectively. The average number of corpora lutea and unovulatory follicles were H±7.58 and 6.33±2.18 and 2.0±0.70 and 2.66±0.66, in group 1 and 2, respectively. The average total number of embryos and transferable embryos in group 1 was 1.75±1.75 and zero, respectively, while in group 2 it was 5±4.51 and 4±3.15, respectively. Source

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