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Sharma K.,Shaheed Hasan Khan Mewati SHKM Government Medical College | Behera J.K.,Government Medical College GMC | Kumar N.,Shaheed Hasan Khan Mewati SHKM Government Medical College | Sood S.,Post Graduate Institute of Medical science PGIMS | And 2 more authors.
North American Journal of Medical Sciences | Year: 2015

Background: Hypothyroidism is known to be associated with impairment of hearing. The hearing impairment may be conductive, sensorineural, or mixed. Aims: The aim is to assess the auditory pathway by brainstem auditory evoked potentials (BAEPs) in newly diagnosed patients of subclinical hypothyroidism and healthy sex- and age-matched controls. Materials and Methods: The study included 25 healthy sex- and age-matched controls (Group I) and 25 patients of newly diagnosed subclinical hypothyroidism (Group II). The recording was taken by using RMS EMG EP MK2 equipment. The unpaired Student’s t-test was used and a P value <0.05 was considered signifi cant. Results: Wave V of right ear BAEP in group II was prolonged (6 ± 0.62 ms) compared to group I (5.49 ± 0.26 ms), and wave V of left ear BAEP in group II was prolonged (5.84 ± 0.57 ms) compared to group I (5.47 ± 0.35 ms). There was no signifi cant coeffi cient of correlation between wave V and inter-peak latency (IPL) I-V compared to thyroid-stimulating hormone (TSH) levels of both the ears. Conclusion: The prolongation of wave V in BAEPs of both ears suggests that the central auditory pathway is affected signifi cantly in subclinical hypothyroid patients. © 2015, North American Journal of Medical Sciences. All rights reserved. Source


Vashist M.,Md University | Kumar A.,Md University | Kamal N.,Md University | Kairo J.,Post Graduate Institute of Medical science PGIMS
Biosciences Biotechnology Research Asia | Year: 2011

Mental retardation is among the few major disorders that are still poorly understood in terms of etiopathogenesis and for which very little therapeutic help is provided. Mental retardation may be caused by either genetic or environmental factors or a combination of both. Fifty nine patients of idiopathic mental disability were studied from Pt.B.D.Sharma University of Health Sciences Rohtak, Haryana. There were 13.5% mild, 49.2% moderate, 27.1% severe & 10.2% profound cases of mental retardation. Out of these there were 72.88% males & 27.11% females. All of these patients were with low socio-economic status and illiterate background. Age group range of 11-20 years has highest frequency (47.457%) of mental disability in all categories. In mild group prenatal, postnatal & neonatal risk factors were found in two, five & four respectively. Among moderate group 18 patients were with prenatal risk factors, 19 with postnatal, 24 with neonatal & 2 patients were without any risk factors. In severe group 9 patients have prenatal, 16 patients have postnatal & 16 patients have neonatal risk factors. In profound group prenatal, postnatal & neonatal risk factors were noted in four, six & six patients respectively. Source


Basu A.,Post Graduate Institute of Medical science PGIMS | Seth S.,Post Graduate Institute of Medical science PGIMS | Chauhan A.K.,Post Graduate Institute of Medical science PGIMS | Bansal N.,Post Graduate Institute of Medical science PGIMS | And 2 more authors.
Annals of Translational Medicine | Year: 2016

Background: Colorectal carcinoma (CRC), the second leading cause of cancer-related deaths in US, has a rising time-trend in India. Tumour markers in CRC are extensively researched, and there's still debate on their diagnostic and prognostic values. Methods: In this hospital-based longitudinal study in north India, 51 male diagnosed CRC cases (pre-chemotherapy) were contrasted against 50 age and sex matched controls. Nine biomarkers: Carcinoembryonic antigen (CEA), prolactin (PRL), alfa feto protein (AFP), total human chorionic gonadotropin (hCG), cancer antigen-125 (CA-125), serum testosterone, prostate specific antigen (PSA) and ferritin were measured by direct chemiluminescence technique. Further, follow-up was done on 47 cases after treatment with six cycles of 5-flurouracil (5-FU) and oxaliplatin. Results: Mean serum CEA (case: 5.94±8.27 ng/mL, control: 2.5±0.79 ng/mL, P < 0.05), PRL (case: 28.12±13.39 ng/mL, control: 14.24±13.13 ng/mL, P < 0.0001), AFP (case: 10.9±6.65 ng/mL, control: 4.02±1.26 ng/mL, P < 0.0001) levels were significantly raised in CRC cases compared to controls. On the contrary, mean testosterone level (P < 0.05) was lower among the cases. After chemotherapy, the mean serum CEA (P < 0.05), AFP (P < 0.0001) and CA-125 (P < 0.05) levels among the cases decreased significantly compared to their pretreatment levels. Conclusions: The present study strongly indicates the role of CEA, PRL, AFP, CA-125 and testosterone as important biomarkers in male CRC patients from north India. Further, AFP, CA-125 and CEA may be used to assess the effectiveness of chemotherapy in such patients. © Annals of Translational Medicine. All rights reserved. Source


Basu A.,Post Graduate Institute of Medical science PGIMS | Seth S.,Post Graduate Institute of Medical science PGIMS | Arora K.,VMMC and Safdarjung Hospital | Verma M.,Post Graduate Institute of Medical science PGIMS
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Globally more than 1 million people suffer from colorectal cancer (CRC) per annum, resulting in about 0.5 million deaths. The role of estrogen in CRC is being researched with great interest; expression of estrogen receptors (alfa and beta) is being explored.Aims and Objective: Our objective was to compare the serum estradiol levels in diagnosed male patients of CRC, with age-matched controls; and to study the estradiol levels across the different stages of CRC.Setting and design: A cross-sectional study was conducted from January, 2012 to March, 2013 at a tertiary care hospital in north India.Materials and Methods: Fifty one male preoperative CRC patients were enrolled along with 50 age-matched male controls. Ethical approval and informed written consent from each participant were duly obtained. CRC patients were staged as per TNM (T- Tumour, N- Node, M- Metastasis; I, II, III and IV) criteria. Serum estradiol level was measured by Chemiimmunofluroscence method (normal = 11.6 - 41.2 pg/ml).Statistical analysis used: We used student’s t test and ANOVA (analysis of variance) to analyse the data (SPSS version 17.0, SPSS, Inc., Chicago, Illinois)Result:The mean serum estradiol level among CRC patients (43.4, sd=27.1) was significantly more than that among controls (mean=24.7, sd=17.5), (p<0.0001). Across the four TNM stages of CRC patients, mean estradiol level was highest in Stage II (55.9, sd=15.5); followed by Stages III (44.1, sd=24.9), IV (36.3, sd=30.0) and I (26.4, sd=38.8). However, significant difference was obtained only between Stages I and II.Conclusion: Our study revealed increased levels of serum estradiol in Indian male CRC patients. Further research is warranted to corroborate this finding, and to understand the role of estradiol across different TNM stages of CRC. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Sharma S.,Post Graduate Institute of Medical science PGIMS | Sharma S.,Post Graduate Institute of Medical Education and Research | Singh S.K.,Post Graduate Institute of Medical science PGIMS | Pawar D.S.,Post Graduate Institute of Medical science PGIMS | Khandelwal A.,Post Graduate Institute of Medical science PGIMS
UroToday International Journal | Year: 2010

Condyloma acuminatum generally has been considered a benign growth with no malignant potential. The present patient presented with condylomata acuminate of the penis and concomitant invasive squamous cell carcinoma. Partial amputation of the penis along with cauterization of the warts was successfully undertaken. © 2010 UroToday International Journal. Source

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