Sharma Post Graduate Institute

Rohtak, India

Sharma Post Graduate Institute

Rohtak, India
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Data concerning the cardiovascular risk factors in cord blood of newborn babies of preeclamptic mothers are very limited. The present study was designed to investigate the relation between concentrations of homocysteine, vitamin B12 and folic acid in maternal sera and in the venous umbilical cord sera of the corresponding newborn babies. Levels of homocysteine, vitamin B12 and folic acid in fifty normotensive pregnant women (group I) were compared with the corresponding levels of fifty women with pregnancy induced hypertension (PIH, group II). Mean values of homocysteine, folic acid were higher in maternal blood of hypertensive pregnant women as compared to normotensive pregnant women (p < 0.001, p > 0.05, respectively). Mean value of vitamin B12 was lower in maternal blood of hypertensive pregnant women compared to normotensive pregnant women (p > 0.05). Mean values of homocysteine, folic acid were higher in cord blood of hypertensive pregnant women compared to normotensive pregnant women (p < 0.001, p < 0.01 respectively). Mean value of vitamin B12 was lower in cord blood of hypertensive pregnant women compared to normotensive pregnant women (p < 0.01). Positive correlation was found between fetal homocysteine and gestational age at delivery in group II. A negative correlation was found between homocysteine and folic acid levels of mothers in group II which was statistically significant. Since vitamin deficiency is a preventable cause of tissue damage, especially in developing human fetuses, studies of the effects of maternal folate and vitamin deficiency through pregnancy on homocysteine levels and vascular physiology in pregnant women, the placenta, and the newborn infant, could be of help in treating preeclampsia and the prevention of future cardiovascular risk. Copyright © Sociedad Iberoamericana de Información Científica (SIIC), 2012.

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