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Kavyashree D.,Visveswaraya Technological University | Shilpa C.J.,Tumkur University | Nagabhushana H.,Tumkur University | Daruka Prasad B.,Bangalore University | And 5 more authors.
ACS Sustainable Chemistry and Engineering | Year: 2015

In this paper, a robust and simple biogenic route has been developed to synthesize self-assembled ZnO superstructures in short intervals of time using naturally available aloe vera plant gel and zinc nitrate as starting materials. The stabilization of zinc ions with polysaccharides wrapped chains along with the support of proteins, lipids and physterols of aloe vera gel followed by combustion derives the ZnO superstructures. The obtained ZnO superstructures show a hexagonal crystal phase and exhibit a semiconducting behavior with the energy band gap varies from 2.92 to 3.08 eV. The aloe vera gel derived ZnO superstructures exhibit unique and strong orange-red emission centered at 600 nm. The better structural, morphological and photoluminescence results are obtained for ZnO prepared with 16.6% W/V of zinc nitrate with aloe vera content compared to other concentrations of aloe vera. The prepared compounds are tested for antimalassezial activity against Malassezia furfur, dermatologically prevalent yeast, and were found to have minimum inhibitory concentration (MIC) values ranging from 8 to 125 mL. Fluorescence microscopic analysis revealed that yeast cells treated with ZnO superstructures have the chromatin as orange instead of green, showcasing the cell aggregation suggests that ZnO superstructures have an immense potential as an antifungal agent. Hence, the explored method of preparation shows high efficient ZnO superstructures derived from the aloe vera plant gel have potential applications in the medical, biomedical and cosmetic industries. © 2015 American Chemical Society.


De Almeida E.O.,Federal University of Rio Grande do Norte | Kina S.,Post Graduate Center | Fasolo G.B.,Post Graduate Center
Journal of Craniofacial Surgery | Year: 2012

Purpose: In view of reports in the literature on the benefits achieved with the use of platform switching, described as the use of an implant with a larger diameter than the abutment diameter, the goal being to prevent the (previously) normal bone loss down to the first thread that occurs around most implants, thus enhancing soft tissue aesthetics and stability and the need for implant inclination due to bone anatomy in some cases, the aim of this study was to evaluate bone stress distribution on peri-implant bone, by using three-dimensional finite element analysis to simulate the influence of implants with different abutment angulations (0 and 15 degrees) in platform switching. Methods: Four mathematical models of an implant-supported central incisor were created with varying abutment angulations: straight abutment (S1 and S2) and angulated abutment at 15 degrees (A1 and A2), submitted to 2 loading conditions (100 N): S1 and A1-oblique loading (45 degrees) and S2 and A2-axial loading, parallel to the long axis of the implant. Maximum (σ max) and minimum (σ min) principal stress values were obtained for cortical and trabecular bone. Results: Models S1 and A1 showed higher σ max in cortical and trabecular bone when compared with S2 and A2. The highest σ max values (in MPa) in the cortical bone were found in S1 (28.5), followed by A1 (25.7), S2 (11.6), and A2 (5.15). For the trabecular bone, the highest σ max values were found in S1 (7.53), followed by A1 (2.87), S2 (2.85), and A2 (1.47). Conclusion: Implants with straight abutments generated the highest stress values in bone. In addition, this effect was potentiated when the load was applied obliquely. Copyright © 2012 by Mutaz B. Habal, MD.


Basawaraj R.,Post Graduate Center | Goled S.N.,Gulbarga University | Khandre O.,Gulbarga University | Sangapure S.S.,Gulbarga University
Indian Journal of Heterocyclic Chemistry | Year: 2011

2-(2,4,6-Trimethoxy phenyl/α-naphthyl)-4-hydrazinobenzofuro [3,2-d] pyrimidines 5,6 were prepared by the nuleophilic displacement reaction of 2-(trimethoxy phenyl/α-naphthyl)-4-chlorobenzofuro [3,2-d] pyrimidines 3,4 with hydrazine hydrate in methanol. The reaction of 2-substituted-4- hydrazinobenzofuro [3,2-d] pyrimidines 5,6 with acetyl acetone, ethyl cynoacetate and ethyl acetoacetate in sodium ethoxide furnished pyrazolinobenzofuran [3,2-d] pyrimidines 7-12 respectively. Structures of all newly synthesized compounds were ascertained on the basis of analytical and spectral studies. Further these compounds were evaluated for their antimicrobial and antiinflammatory properties.


Ramu R.,Post Graduate Center | Ramu R.,JSS Technical Institutions Campus | Shirahatti P.S.,JSS Technical Institutions Campus | Nanjunda S.S.,JSS Technical Institutions Campus | And 3 more authors.
PLoS ONE | Year: 2016

Banana is an extensively cultivated plant worldwide, mainly for its fruit, while its ancillary product, the banana flower is consumed as a vegetable and is highly recommended for diabetics in the traditional Indian medicine system. This study is based on an investigation of the in vivo antihyperglycaemic activity of Umbelliferone (C1) and Lupeol (C2) isolated from the ethanol extract of banana flower (EF) in alloxan induced diabetic rat model. Diabetic rats which were administered with C1, C2 and EF(100 and 200mg/kg b. wt.) for 4 weeks showed deterioration in fasting hyperglycaemia and reversal of abnormalities in serum/urine protein, urea and creatinine, when compared to the diabetic control group of rats. The diabetic group of rats fed with EF, C1 and C2 (100 mg/kg b. wt.) once daily, for a period of 28 days resulted in a significant reduction of diabetic symptoms viz., polyphagia, polydipsia, polyuria and urine sugar together with an improved body weight. HbA1 c extent was reduced whereas levels of insulin and Hb were increased. Both the extract and compounds wielded positive impacts in diabetic rats by reversal of altered activities of hepatic marker enzymes viz., aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP); glycolytic enzyme (hexokinase); shunt enzyme (glucose-6-phosphate dehydrogenase); gluconeogenic enzymes (glucose-6-phosphatase, fructose-1,6-bisphosphatase, lactate dehydrogenase) and pyruvate kinase. The characteristic diabetic complications such as hypercholesterolemia and hypertriacylglycerolemia also significantly reverted to normal in the serum/liver of diabetic rats. Besides these, the treatment increased the activities of enzymatic and non-enzymatic antioxidants in the serum and liver. The histological observations revealed a marked regeneration of the β-cells in the drug treated diabetic rats. In conclusion, the present study illustrates that EF, C1 and C2 enhances the glycolytic activities, besides increasing the hepatic glucose utilization in diabetic rats by stimulating insulin secretion from the remnant β-cells along with potential enzymatic and non-enzymatic antioxidant activities. © 2016 Ramu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Vechiato-Filho A.J.,Paulista University | Dos Santos D.M.,Paulista University | Goiato M.C.,Paulista University | Moreno A.,Paulista University | And 4 more authors.
American Journal of Dentistry | Year: 2015

Purpose: To analyze whether immersion in sodium fluoride (NaF) solutions and/or common acidic beverages (test solutions) would affect the surface roughness or topography of lithium disilicate ceramic. Methods: 220 ceramic discs were divided into four groups, each of which was subdivided into five subgroups (n = 11). Control group discs were immersed in one of four test beverages for 4 hours daily or in artificial saliva for 21 days. Discs in the experimental groups were continuously immersed in 0.05% NaF, 0.2% NaF, or 1.23% acidulated phosphate fluoride (APF) gel for 12, 73, and 48 hours, respectively, followed by immersion in one of the four test beverages or artificial saliva. Vickers microhardness, surface roughness, scanning electron microscopy (SEM) associated with energy dispersive spectroscopy, and atomic force microscopy (AFM) assessments were made. Data were analyzed by nested analysis of variance (ANOVA) and Tukey's test (a = 0.05). Results: Immersion in the test solutions diminished the microhardness and increased the surface roughness of the discs. The test beverages promoted a significant reduction in the Vickers microhardness in the 0.05% and 0.2% NaF groups. The highest surface roughness results were observed in the 0.2% NaF and 1.23% APF groups, with similar findings by SEM and AFM. Acidic beverages affected the surface topography of lithium disilicate ceramic. Fluoride treatments may render the ceramic surface more susceptible to the chelating effect of acidic solutions.


Al-Kadasi A.M.A.,Post Graduate Center | Nazeruddin G.M.,Post Graduate Center
Asian Journal of Chemistry | Year: 2011

A simple and facile ultrasound promoted one pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives, via perchloric acid catalyzed condensation reaction of β-naphthol and aryl aldehydes is described, having the advantages of excellent yields, short reaction time and mild reaction conditions.


Vijaya H.M.,Post Graduate Center | Mallikarjuna Gowda A.P.,Post Graduate Center | Nehru S.D.,Post Graduate Center
Annals of Biology | Year: 2014

The present experiment was undertaken at Post Graduate Centre, University of Horticultural Sciences Campus, Gandhi Krishi Vigyana Kendra, Bangalore during rabi season of 2011-12 to evaluate 24 chilli genotypes for different growth and yield parameters. The genotype Chikballapur Local was found to have maximum plant height (118.6 cm) and plant spread (0.481 m2), while genotype Sankeshwar recorded higher number of primary branches per plant (7.47) and maximum fruit length (14.61 cm). Genotype Byadgi Dabbi was observed for maximum fruit diameter (1.60 cm), pericarp weight (0.80 g), stalk weight (0.14 g) and number of seeds per fruit (98.42). The higher number of fruits per plant (186.30) and dry fruit yield (97.33 g/plant) were recorded in the genotype Sankeshwar followed by genotype LCA-206.


De Almeida E.O.,São Paulo State University | Rocha E.P.,São Paulo State University | Kina S.,Post Graduate Center
Journal of Craniofacial Surgery | Year: 2012

Purpose: The aim of this study was to evaluate stress distribution on peri-implant bone simulating the influence of implants with different lengths on regular and switching platforms in the anterior maxilla by means of three-dimensional finite element analysis. Materials and Methods: Four mathematical models of a central incisor supported by an external hexagon implant (diameter, 5.0 mm) were created, varying the length (15.0 mm for long implants [L] and 7.0 mm for short implants [S]) and the diameter of the abutment platform (5.0 mm for regular models [R] and 4.1 mm for switching models [S]). The models were created using the Mimics 11.11 (Materialise) and SolidWorks 2010 (Inovart) software. Numerical analysis was performed using ANSYS Workbench 10.0 (Swanson Analysis System). Oblique forces (100 N) were applied to the palatine surface of the central incisor. The bone/implant interface was considered perfectly integrated. Maximum (σmax) and minimum (σ min) principal stress values were obtained. Results: For the cortical bone, the highest stress values (σ max) were observed in the SR (73.7 MPa) followed by LR (65.1 MPa), SS (63.6 MPa), and LS (54.2 MPa). For the trabecular bone, the highest stress values (σ max) were observed in the SS (8.87 MPa) followed by the SR (8.32 MPa), LR (7.49 MPa), and LS (7.08 MPa). Conclusions: The influence of switching platform was more evident for the cortical bone in comparison with the trabecular bone for the short and long implants. The long implants showed lower stress values in comparison to the short implants, mainly when the switching platform was used. Copyright © 2012 by Mutaz B. Habal, MD.


Basawaraj R.,Post Graduate Center | Alvi S.N.,Post Graduate Center | Chillargi N.,Post Graduate Center | Gahininath W.,Post Graduate Center | Zaheeruddin M.D.,Post Graduate Center
Indian Journal of Heterocyclic Chemistry | Year: 2011

The condensation of 5-chloro-2-hydroxyacetophenone 1 with different substituted aromatic aldehydes in ethanol in presence of strong alkali furnished 1-(2-hydroxy-5-chlorophenyl)-3-aryl propen-1-ones 2a-e. Bromination of compounds 2a-e in acetic acid gave 1-(2-hydroxy-5-chlorophenyl)-3-aryl 2,3-dibromopropan-1-ones 3a-e which upon treatment with o-phenylenediamine in methanol in presence of cone sulphuric acid underwent cyclization and resulted in the formation of quinoxaline derivatives 4ae. Structures of compounds were established on the basis of analytical and spectral studies. Further these compounds were evaluated for their antimicrobial activities and some selected compounds were evaluated for antitubercular activities.


PubMed | Post Graduate Center
Type: Journal Article | Journal: Journal of prosthodontic research | Year: 2012

To evaluate the stress distribution in peri-implant bone by simulating the effect of an implant with microthreads and platform switching on angled abutments through tridimensional finite element analysis. The postulated hypothesis was that the presence of microthreads and platform switching would reduce the stress concentration in the cortical bone.Four mathematical models of a central incisor supported by an implant (5.0 mm 13 mm) were created in which the type of thread surface in the neck portion (microthreaded or smooth) and the diameter of the angled abutment connection (5.0 and 4.1mm) were varied. These models included the RM (regular platform and microthreads), the RS (regular platform and smooth neck surface), the SM (platform switching and microthreads), and the SS (platform switching and smooth neck). The analysis was performed using ANSYS Workbench 10.0 (Swanson Analysis System). An oblique load (100N) was applied to the palatine surface of the central incisor. The bone/implant interface was considered to be perfectly integrated. Values for the maximum ((max)) and minimum ((min)) principal stress, the equivalent von Mises stress ((vM)), and the maximum principal elastic strain ((max)) for cortical and trabecular bone were obtained.For the cortical bone, the highest (max) (MPa) were observed for the RM (55.1), the RS (51.0), the SM (49.5), and the SS (44.8) models. The highest (vM) (MPa) were found for the RM (45.4), the SM (42.1), the RS (38.7), and the SS models (37). The highest values for (min) were found for the RM, SM, RS and SS models. For the trabecular bone, the highest (max) values (MPa) were observed in the RS model (6.55), followed by the RM (6.37), SS (5.6), and SM (5.2) models.The hypothesis that the presence of microthreads and a switching platform would reduce the stress concentration in the cortical bone was partially rejected, mainly because the microthreads increased the stress concentration in cortical bone. Only platform switching reduced the stress in cortical bone.

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