Aurangābād, India
Aurangābād, India

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Hussain S.,Sir Sayyed College | Shaikh S.,Sir Sayyed College | Farooqui M.,Post Graduate and Research Center
Journal of Saudi Chemical Society | Year: 2013

Active pharmaceutical intermediates (API) in waste waters have adverse effects on aquatic life and environment. The API have high COD value and low BOD3 and hence difficult to treat biologically. In this study, advanced oxidation processes (AOPs) utilizing the H2O2/Fe+2, Fenton reactions were investigated in lab-scale experiments for the degradation of Atenolol containing waste water streams. The experimental results showed that the Fenton process using H2O2/Fe+2 was the most effective treatment process. With Fenton processes, COD reduction of wastewater can be achieved successfully. It is suggested that Fenton processes are viable techniques for the degradation of Atenolol from the waste water stream with relatively low toxic by-products in the effluent which can be easily biodegraded in the activated sludge process. Hence, the Fenton process with H2O2/Fe+2 is considered a suitable pretreatment method to degrade the active pharmaceutical molecules and to improve the biodegradability of waste water. © 2011.

More U.B.,Post Graduate and Research Center
Asian Journal of Chemistry | Year: 2012

An efficient one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from an aldehyde, b-ketoester and urea/thiourea, using nickel chloride pentahydrate is described. The protocol is described using three different sets of reaction conditions. The method provides much improved modification of original Biginelli reaction, in terms of high yield, short reaction time and simple workup procedure.

Ali N.A.S.,Post Graduate and Research Center | Zakir S.,Post Graduate and Research Center | Patel M.,Post Graduate and Research Center | Farooqui M.,Post Graduate and Research Center
European Journal of Medicinal Chemistry | Year: 2012

We are reporting herein for the first time the synthesis of α-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to α- aminophosphonates using chlorotrimethylsilane (TMSCl) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial strains. © 2012 Elsevier Masson SAS. All rights reserved.

Chikate R.C.,Post graduate and Research Center | Kadu B.S.,Post graduate and Research Center
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2014

To ascertain the contribution of adsorptive capacity of Montmorillonite (MMT) towards photocatalytic process, CdSe-MMT nanocomposites are explored for adsorptive removal of Indigo Carmine (IC). The nanocomposites are prepared via two approaches: (a) in-situ formation and (b) wet impregnation of CdSe onto MMT support. XRD analysis of composites suggested the proper dispersion of CdSe nanoparticles in MMT clay matrix with spherical morphology of 5-10 nm sized CdSe nanoparticles. These nanocomposites are employed for photocatalytic degradation of IC under visible light at various IC concentrations and different amount of catalyst. Kinetics of IC is found to be of pseudo-second order with 10% in-situ and 50% loaded nanocomposites exhibiting better photocatalytic activity at 1.0 g L-1 catalyst and 100 mg L-1of IC. Dynamics of its adsorptive removal on the composite surface evaluated by employing error estimation tools clearly suggest that Redlich-Peterson and Flory-Huggins adsorption isotherms effectively describe the multi-layer process. It is observed that spontaneous, exothermic chemisorption process occurring on the surface indeed enhances photocatalytic activity. Moreover, such a feature is also found to be associated with diffusion of IC within mesoporous structure of MMT that subsequently favors pore-diffusion controlled adsorption process. IR spectral analysis demonstrated that IC molecule is degraded on the catalyst surface. Light or oxygenated species induced photocorrosion of CdSe is suppressed due to its composite formation with MMT that results in 620 ppm removal of IC during successive cycles; a feature ascribed as improved photocatalytic activity for CdSe nanoparticles. © 2014 Elsevier B.V. All rights reserved.

Doke K.M.,Post Graduate and Research Center | Khan E.M.,Post Graduate and Research Center
Arabian Journal of Chemistry | Year: 2012

In the present investigation, adsorbent activated charcoal was prepared from wood apple shell by chemical activation and used for Cr(VI) removal from aqueous solutions. Powdered wood apple shell was activated by acid H 2SO 4 and heat treatment in muffle furnace at 600 °C for 2 h. The specific surface area of prepared activated carbon was found to be 1898 m 2 g -1. Batch adsorption studies reveal that the prepared activated charcoal has a significant capacity for adsorption of Cr(VI) from aqueous solutions. The equilibrium adsorption isotherms investigated in this study include Langmuir and Freundlich at 300 K. The Cr(VI) adsorption was found to be maximum (>95.0%) at pH 1.8. Very small amount of adsorbent activated carbon (1.25 g L -1) could remove >95.0% Cr(VI) from aqueous solution of initial concentration 75 mg L -1. The Langmuir monolayer adsorption capacity of Cr(VI) adsorption on activated carbon was found to be 151.51 mg g -1. The dimensionless separation factor (R L) signifies a favorable adsorption of Cr(VI) on activated charcoal. Adsorption kinetic studies reveal that the adsorption of Cr(VI) onto activated carbon was pseudo-second order chemisorptions and follows film-diffusion as well as intra-particle pore-diffusion mechanism. © 2012.

Ahad A.,Post Graduate and Research Center | Farooqui M.,Post Graduate and Research Center
Research on Chemical Intermediates | Year: 2016

Molecular diversity for the synthesis of pyran annulated heterocyclic scaffolds has been achieved from the multicomponent reaction of aldehyde, malonitrile and a third participant such as dimedone, barbituric acid and 3-methyl-1H-pyrazol-5(4H)-one. The reactions completed successfully using in situ-developed benzylidenemalononitriles via Knoevenagel reaction catalyzed by aspartic acid as a new efficient organo-catalyst in aqueous ethanol as a green medium at ambient conditions. © 2016 Springer Science+Business Media Dordrecht

Sawant S.S.,Post Graduate and Research Center
International Journal of Applied Chemistry | Year: 2015

Rhenium was determined spectrophotometrically after extraction of its complex with 5-chloro-2-hydroxythiobenzhydrazide into molten naphthalene from 0.4 - 3.5 M hydrochloric acid medium. Beers law was obeyed in the concentration range 2.0 - 20.0 ppm of rhenium in a chloroform solution at 580 nm. The molar absorptivity and Sandell sensitivity were 0.931 X 10 4 l mol-1 cm-1 and 0.02 ppm, respectively. Six replicate analyses of a solution containing 8.0 ppm of rhenium gave a mean absorbance of 0.405 with a standard deviation of 0.0035 and a relative standard deviation of 0.86%. The complex was stable for over 24 h. The metal- to -ligand ratio in the complex was 1:3. Interference from various ions was studied, and the method was applied to the determination of rhenium in various alloy samples. The method permits the sequential separation and determination of ruthenium, rhenium and osmium from their Mixtures. © Research India Publications.

Chikate R.C.,Post graduate and Research Center | Kadu B.S.,Post graduate and Research Center | Damle M.A.,MES Abasaheb Garware College
RSC Advances | Year: 2014

In this paper, we have developed an efficient electrostatic self-assembly strategy for the synthesis of a CdSe-CTAB-MMT composite that contains well-dispersed CdSe quantum dots (CdSe QDs) within the MMT structure. These nanocomposites are characterised by XRD, TEM, Raman, DRS and photoluminescence studies which indicate that 3-5 nm sized CdSe QDs are intercalated within lamellar sheets of MMT. Visible light induced photocatalytic activities of the composites exhibit decolourisation of Indigo Carmine (IC) solution (100 mg L-1) within 30 min. at 1.0 g L-1 catalyst loading. This feature is attributed to separation of photogenerated electron-hole pairs, enhanced interlayer spacing (7.2 A°), higher specific surface area and better adsorption capacity of the MMT. The involvement of reactive oxygen species (ROS) in the photodegradation process is ascertained by addition of selective quenchers such as NaN3 (for singlet oxygen), benzoquinone (for O2 -), ascorbic acid (for OH) and KI (for h +). It is observed that singlet oxygen and photogenerated h + do not contribute towards degradation; rather O2 - is a prominent species that degrades ∼74% of IC while the remaining part is oxidized by OH. The photodegradation pathway involves desulphonation of IC followed by its oxidation to isatin, anthranilic acid, tryptanthrin and isatoic anhydride. The antibacterial studies of degraded IC solution as well as chemoinformatics studies suggest that these metabolites are non-toxic in nature. These catalysts remain active for up to 6 cycles with a marginal decrease in their removal capacity that can be ascribed to inhibition of photocorrosion even after successive exposure to light. Thus, nano-engineered CdSe-composites may be regarded as efficient photocatalysts that have potential applications in sustainable development towards continuous removal of organic dyes from aqueous streams. This journal is © the Partner Organisations 2014.

Doke K.M.,Post Graduate and Research Center | Khan E.M.,Post Graduate and Research Center
Reviews in Environmental Science and Biotechnology | Year: 2013

The current review paper deals with critical evaluation of the thermodynamic parameters of adsorption equilibrium uptakes of heavy metals, dyes and other organic pollutants from the wastewater using low-cost adsorbents, activated carbon derived from agricultural waste, industrial wastes and other important adsorbent materials. Present review paper focus the spontaneity of adsorption processes when the thermodynamic parameters were assessed with the compensation effects of standard enthalpy change (ΔHo) and standard entropy change (ΔSo) with temperature. This paper also investigates the spontaneity of adsorption on the basis of thermodynamic criteria of spontaneity and the temperature range to predict feasibility of the adsorption processes. © 2012 Springer Science+Business Media B.V.

Kasawar G.B.,Post Graduate and Research Center | Farooqui M.,Post Graduate and Research Center
Journal of Pharmaceutical and Biomedical Analysis | Year: 2010

A simple, sensitive and specific RP-HPLC method was developed for the quantification of related impurities of albuterol sulfate (AS) and ipratropium bromide (IB) in liquid pharmaceutical dosage form. The chromatographic separation employs gradient elution using an inertsil C8-3, 250 mm × 4.6 mm, 5 μm columns. Mobile phase consisting of solvent A (solution containing 2.5 g of potassium dihydrogen phosphate and 2.87 g of heptane-1-sulfonic acid sodium salt per liter of water, adjusted to pH 4 with orthophosphoric acid) and solvent B (acetonitrile) delivered at a flow rate of 1.0 ml min-1. The analytes were detected and quantified at 210 nm using photodiode array (PDA) detector. The method was validated as per ICH guidelines, demonstrating to be accurate and precise (repeatability and intermediate precision level) within the corresponding linear range of known impurities of AS and IB. The specificity of the method was investigated under different stress conditions including hydrolytic, oxidative, photolytic and thermal as recommended by ICH guidelines. Relevant degradation was found to take place under hydrolytic and oxidative conditions. Robustness against small modification in pH, column oven temperature, flow rate and percentage of the mobile phase composition was ascertained. Lower limit of quantification and detection were also determined. The peak purity indices (purity angle < purity threshold) obtained with the aid of PDA detection and satisfactory resolution between related impurities established the specificity of the determination. All these results provide the stability indicating capability of the method. © 2009 Elsevier B.V. All rights reserved.

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