Post gastrectomy Patients Association ALPHA CLUB

Tokyo, Japan

Post gastrectomy Patients Association ALPHA CLUB

Tokyo, Japan
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Aoki T.,Jikei University School of Medicine | Asahara T.,Yakult Central Institute for Microbiological Research | Matsumoto K.,Yakult Central Institute for Microbiological Research | Takada T.,Yakult Central Institute for Microbiological Research | And 8 more authors.
Scandinavian Journal of Gastroenterology | Year: 2014

Objective. This article is based on our previously reported results of irregular bowel movement and disturbances of the intestinal microbiota/ environment in gastrectomized patients. A placebo-controlled, double-blind comparative study was carried out to evaluate the effects of a fermented milk beverage containing Lactobacillus casei strain Shirota (LcS) in such patients. The major evaluated factors of this article were "bowel movement" and "quality of life." The secondary evaluated factors were "fecal microbiota" and "enteric environment." Methods. Of the 190 gastrectomized subjects who participated in our previously reported defecation survey, 134 subjects judged as having abnormal defecation gave consent to participate in this study. These subjects continuously ingested the test beverage containing 40 billion LcS or placebo (one bottle per day, 4 weeks). Results. In the LcS-ingested group, among the 118 subjects who completed the tests, the assessments of the subjects were based on their division into groups based on their symptoms with our scoring system for constipation/diarrhea; although there was no significant ingestion effect in total, in the constipation group, LcS reduced the degree of constipation compared with that in the placebo group. In the diarrhea group, LcS ingestion improved diarrhea compared with that in the preingestion state. Fecal Staphylococcus level was decreased. Conclusions. The results suggest the possibility that the continuous consumption of LcS-fermented milk relieves irregular bowel movement in gastrectomized patients. © 2014 Informa Healthcare.


Aoki T.,Jikei University School of Medicine | Yamaji I.,Post gastrectomy Patients Association ALPHA CLUB | Hisamoto T.,Post gastrectomy Patients Association ALPHA CLUB | Sato M.,Post gastrectomy Patients Association ALPHA CLUB | Matsuda T.,Post gastrectomy Patients Association ALPHA CLUB
Gastric Cancer | Year: 2012

Background We conducted a survey regarding irregular bowel movement in gastrectomized patients. Their defecation frequency, intestinal microflora, and intestinal environment were studied and compared with those of healthy controls. Methods As a first step, a questionnaire survey on bowel movement, involving 769 patients and 312 healthy controls (total: 1,081 subjects), was carried out. As a second step, the defecation frequency (scoring of the survey results conducted to evaluate the state of constipation/diarrhea), intestinal microflora, and intestinal environment were evaluated in 190 gastrectomized patients with irregular bowel movement and 31 controls identified in the first survey. Results First step: Of the 769 patients, 58% complained of irregular bowel movements (constipation, diarrhea, or their alternate occurrence), and their frequency of complaints was significantly higher (p < 0.01) than that in the healthy controls (33%). Second step: The levels of the most predominant obligate anaerobe and harmful bacteria in the feces were lower and higher, respectively, the fecal pH was lower, the fecal water content was lower, and the level of putrefactive metabolites in the feces was higher in the gastrectomized patients than in the healthy controls. The intestinal flora and environment were more disrupted in the totally gastrectomized than in the partially gastrectomized patients. Conclusions Many gastrectomized patients with irregular bowel movements exhibited significant changes showing impaired intestinal microflora and metabolite levels. © The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2011.

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