News Article | May 23, 2017
Tom Cruise headlines a spectacular, all-new cinematic version of the legend that has fascinated cultures all over the world since the dawn of civilization: THE MUMMY. Thought safely entombed in a tomb deep beneath the unforgiving desert, an ancient princess (Sofia Boutella of Kingsman: The Secret Service and Star Trek Beyond) whose destiny was unjustly taken from her is awakened in our current day, bringing with her malevolence grown over millennia and terrors that defy human comprehension. From the sweeping sands of the Middle East through hidden labyrinths under modern-day London, The Mummy brings a surprising intensity and balance of wonder and thrills in an imaginative new take that ushers in a new world of gods and monsters. Cruise is joined by a cast including Annabelle Wallis (upcoming King Arthur, television's Peaky Blinders), Jake Johnson (Jurassic World), Courtney B. Vance (TV's American Crime Story: The People V. O.J. Simpson), Marwan Kenzari (The Promise) and Oscar® winner Russell Crowe (Gladiator). The creative team on this action-adventure event is led by director/producer Alex Kurtzman and producer Chris Morgan, who have been instrumental in growing some of the most successful franchises of the past several years—with Kurtzman writing or producing entries in the Transformers, Star Trek and Mission: Impossible series, and Morgan being the narrative engineer of the Fast & Furious saga as it has experienced explosive growth from its third chapter on. Sean Daniel, who produced the most recent Mummy trilogy, and Sarah Bradshaw (Maleficent) produce alongside Kurtzman and Morgan. www.themummy.com Founded in 2014, Positron is a technology studio based in Los Angeles that delivers engineering magic. The team includes mechatronics engineers, designers, software developers and artists who collaborate together to create VR experiences and products that have never been done before. Voyager is the first full-motion chair platform designed for cinematic VR. Integrating beautiful design and high-end engineering, it reflects a passion for VR storytelling. Voyager delivers a completely new level of immersion in VR by providing a comfortable, fully integrated personal VR theater that incorporates gentle motorized yaw and pitch motion, haptic feedback (physical audio powered by Subpac), and specialized seating. Its unique software and hardware technology integration enables nuanced motion and haptic tracks to be encoded along the featured content's visual and spatial audio tracks. The chair precisely guides the viewers' attention to points of interest in the experience, while also allowing a viewer-controlled motion mode. Voyager units are available now for select theaters, hotels, concerts, and events that desire to provide a premium VR experience. For Voyager images please visit Positron Media. The Mummy Prodigium Strike, developed by Swedish game developer Starbreeze Studios, is a captivating VR experience where viewers play as a Prodigium Agent and are tasked with capturing the ancient Princess Ahmanet—while battling hordes of ravens, spiders and the undead. From a helicopter hovering above to the intense action on the ground, players must protect their fellow agents as The Mummy grows in power, battling to the finish to capture her, or be her slave for eternity. The Mummy Prodigium Strike utilizes the 210-degree virtual reality headset StarVR® and a unique set of experience-enhancing aids, allowing users to fully transport themselves into the new world of gods and monsters. THE MUMMY arrives in IMAX® and theaters nationwide on Friday, June 9, 2017. www.themummy.com To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/media-alert-universal-pictures-and-the-shop-at-nbc-studios-present-the-mummy-zero-gravity-stunt-vr-experience-at-30-rock-300462001.html
News Article | June 8, 2017
VR technology studio Positron, creators of the world's first full-motion cinematic VR chair, Voyager™, today announced a partnership with the Technicolor Experience Center (TEC) designed to help drive the further development of cinematic VR and the immersive media ecosystem. Voyager™ chair platforms will be installed at the TEC showroom where filmmakers, creators, studio executives, artists and technologists from across the industry come together to realize the full potential of immersive media. “Positron is focused on providing technology and products for premium cinematic VR that both audiences and creators love. We’re thrilled to make Voyager™ technology available to the Technicolor Experience Center and to contribute to this community of thought leaders focused on the creative and economic growth of VR,” said Jennifer Rundell, COO, of Positron. “We’re excited to partner with the Technicolor Experience Center to bring Voyager’s hardware and software platforms to Hollywood’s leading cinematic VR creators,” said Jeffrey Travis, CEO, Positron. “The Voyager platform is designed to set a new standard for cinematic VR and location-based experiences. Our mission is to empower storytellers with better ways of sharing immersive stories.” “Motion and multisensory integration will play a critical role in the effectiveness and adoption of virtual reality and other immersive experiences in the months and years to come, “ said Marcie Jastrow, SVP Immersive Media and Head of the Technicolor Experience Center. The partnership between the Technicolor Experience Center and Positron will provide visionaries in the immersive media community with an opportunity to utilize outstanding multisensory touch points such as motion, scent and haptics into their storytelling experiences.” Positron is a VR technology studio based in Los Angeles that is focused on cinematic VR. The team includes mechatronics engineers, designers, software developers and artists who collaborate together to create premium VR experiences and products. Voyager™ is the first full-motion chair platform designed for cinematic VR. Integrating beautiful design and high-end engineering, it reflects a passion for VR storytelling. Voyager™ delivers a completely new level of immersion in VR by providing a comfortable, fully integrated personal VR theater that incorporates gentle motorized yaw and pitch motion, audio-driven haptic feedback and specialized seating. Its unique software and hardware technology integration enables nuanced motion and haptic tracks to be encoded along the featured content's visual and spatial audio tracks. The chair precisely guides the viewers' attention to points of interest in the experience, while also allowing a viewer-controlled motion mode. Voyager™ units are available now for select theaters, hotels, concerts, and events that desire to provide a premium VR experience. For Voyager images please visit Positron Media. The mission of the Technicolor Experience Center is to enable partnerships and collaboration to create the future of immersive experiences. The Technicolor Experience Center is where artists and scientists from across the industry come together to realize the full potential of immersive media. By uniting talent from Technicolor and its award-winning creative brands (MPC, The Mill, Mr. X and Mikros Image) with partners from fields as diverse as gaming, animation, traditional media and technology, we enable the ideation, exploration and creation that pushes the boundaries of what immersive experiences can be.
Clinical Nuclear Medicine | Year: 2017
BACKGROUND: While PET using F-FDG is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on F-FDG PET scans. The pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. Furthermore, the addition of adjuvants to vaccines can further enhance the immune response. The presented study was designed to define lymph node activation following administration of the Food and Drug Administration–licensed human papillomavirus vaccines, Cervarix and Gardasil, which contain similar antigens with different adjuvants. METHODS: Twenty-seven women aged 18 to 25 years were randomized to receive either Cervarix or Gardasil in the clinical trial VRC 900. Fifteen subjects participated in the PET/CT portion of the trial and received scans of lymph node activation at prevaccination and “1 week” (8–14 days) and “1 month” (23–36 days) after the first or third vaccination. RESULTS: PET/CT scans revealed that all vaccine recipients had ipsilateral axillary lymph node activity. Three of 4 Cervarix recipients also showed contralateral lymph node activity 1 month after the first vaccination. For both Cervarix and Gardasil, the SUV activity resolved over time, with activity extended up to day 37 after the first and third vaccinations. CONCLUSIONS: Following intramuscular vaccination, there were no major differences between duration of uptake and intensity of SUV between Cervarix and Gardasil recipients in ipsilateral axillary lymph nodes. Contralateral node activation was detected up to 1 month after the first vaccination in Cervarix recipients only, possibly reflecting differences in vaccine adjuvant formulation. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Carlson P.J.,University of Utah |
Diazgranados N.,University of Texas Health Science Center at San Antonio |
Nugent A.C.,U.S. National Institutes of Health |
Ibrahim L.,U.S. National Institutes of Health |
And 7 more authors.
Biological Psychiatry | Year: 2013
Background: Multiple lines of evidence support a role for the glutamatergic system in the pathophysiology of major depressive disorder (MDD). Ketamine, an N-methyl-D-aspartate antagonist, rapidly improves depressive symptoms in individuals with treatment-resistant depression. The neural mechanisms underlying this effect remain unknown. Methods: In this preliminary study, 20 unmedicated participants with treatment-resistant MDD underwent positron emission tomography to measure regional cerebral glucose metabolism at baseline and following ketamine infusion (single dose of.5 mg/kg intravenous over 40 minutes). Metabolic data were compared between conditions using a combination of region-of-interest and voxelwise analyses, and differences were correlated with the associated antidepressant response. Results: Whole-brain metabolism did not change significantly following ketamine. Regional metabolism decreased significantly under ketamine in the habenula, insula, and ventrolateral and dorsolateral prefrontal cortices of the right hemisphere. Metabolism increased postketamine in bilateral occipital, right sensorimotor, left parahippocampal, and left inferior parietal cortices. Improvement in depression ratings correlated directly with change in metabolism in right superior and middle temporal gyri. Conversely, clinical improvement correlated inversely with metabolic changes in right parahippocampal gyrus and temporoparietal cortex. Conclusions: Although preliminary, these results indicate that treatment-resistant MDD subjects showed decreased metabolism in the right habenula and the extended medial and orbital prefrontal networks in association with rapid antidepressant response to ketamine. Conversely, metabolism increased in sensory association cortices, conceivably related to the illusory phenomena sometimes experienced with ketamine. Further studies are needed to elucidate how these functional anatomical changes relate to the molecular mechanisms underlying ketamine's rapid antidepressant effects. © 2013 Society of Biological Psychiatry.
Smith J.F.,U.S. National Institutes of Health |
Pillai A.,U.S. National Institutes of Health |
Chen K.,Arizona State University |
Chen K.,Positron |
And 2 more authors.
Frontiers in Systems Neuroscience | Year: 2012
Analysis of directionally specific or causal interactions between regions in functional magnetic resonance imaging (fMRI) data has proliferated. Here we identify six issues with existing effective connectivity methods that need to be addressed. The issues are discussed within the framework of linear dynamic systems for fMRI (LDSf).The first concerns the use of deterministic models to identify inter-regional effective connectivity. We show that deterministic dynamics are incapable of identifying the trial-to-trial variability typically investigated as the marker of connectivity while stochastic models can capture this variabil-ity.The second concerns the simplistic (constant) connectivity modeled by most methods. Connectivity parameters of the LDSf model can vary at the same timescale as the input data. Further, extending LDSf to mixtures of multiple models provides more robust connectivity variation. The third concerns the correct identification of the network itself including the number and anatomical origin of the network nodes. Augmentation of the LDSf state space can identify additional nodes of a network.The fourth concerns the locus of the signal used as a "node" in a network. A novel extension LDSf incorporating sparse canonical correlations can select most relevant voxels from an anatomically defined region based on connectivity.The fifth concerns connection interpretation. Individual parameter differences have received most attention. We present alternative network descriptors of connectivity changes which consider the whole network. The sixth concerns the temporal resolution of fMRI data relative to the timescale of the inter-regional interactions in the brain. LDSf includes an "instantaneous" connection term to capture connectivity occurring at timescales faster than the data resolution. The LDS framework can also be extended to statistically combine fMRI and EEG data. The LDSf framework is a promising foundation for effective connectivity analysis. © 2012 Smith, Pillai, Chen and Horwitz.
Chio A.,University of Turin |
Pagani M.,CNR Institute of Neuroscience |
Pagani M.,Karolinska University Hospital |
Agosta F.,Vita-Salute San Raffaele University |
And 4 more authors.
The Lancet Neurology | Year: 2014
In the past two decades, structural and functional neuroimaging findings have greatly modified longstanding notions regarding the pathophysiology of amyotrophic lateral sclerosis (ALS). Neuroimaging studies have shown that anatomical and functional lesions spread beyond precentral cortices and corticospinal tracts, to include the corpus callosum; frontal, sensory, and premotor cortices; thalamus; and midbrain. Both MRI and PET studies have shown early and diffuse loss of inhibitory cortical interneurons in the motor cortex (increased levels of functional connectivity and loss of GABAergic neurons, respectively) and diffuse gliosis in white-matter tracts. In ALS endophenotypes, neuroimaging has also shown a diverse spreading of lesions and a dissimilar impairment of functional and structural connections. A possible role of PET in the diagnosis of ALS has recently been proposed. However, most neuroimaging studies have pitfalls, such as a small number and poor clinical characterisation of patients, absence of adequate controls, and scarcity of longitudinal assessments. Studies involving international collaborations, standardised assessments, and large patient cohorts will overcome these shortcomings and provide further insight into the pathogenesis of ALS. © 2014 Elsevier Ltd.
Indian Journal of Nuclear Medicine | Year: 2013
Ectopic thyroid tissue (ETT) refers to all cases in which the thyroid gland is present at a location other than its usual site. The prevalence of ETT is approximately one per 100,000 to 300,000 persons and is reported to occur in one in 4,000 to 8,000 patients with thyroid disease. Multiple ectopia of thyroid is extremely rare. Multiple ectopia in the presence of orthotopic thyroid gland is extremely rare. We report a 13-year-old boy with stunted growth and developmental delay caused due to acquired hypothyroidism. Technetium scan performed as per management protocol identified dual ectopia of thyroid. The role of hybrid Single-Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT) in the localization of the sites of ETT is also highlighted.
Guerard F.,NCI Inc |
Lee Y.-S.,U.S. National Institutes of Health |
Tripier R.,CNRS Chemistry Laboratory |
Szajek L.P.,Positron |
And 2 more authors.
Chemical Communications | Year: 2013
Single crystal X-ray diffraction shows that Zr(iv) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr. © The Royal Society of Chemistry 2013.
Positron | Date: 2012-04-26
An attenuation correction method and device for an image in a PET system. The method includes: acquiring transmission scanning sinogram data from a PET apparatus; reconstructing the transmission scanning sinogram data with Bayesian model-based Ordered Subset Expectation Maximization (OSEM-B) algorithm and Filtered Back Projection (FBP) algorithm, to obtain an OSEM-B attenuation image and a first FBP attenuation image respectively; performing a weighted calculation on the OSEM-B attenuation image and the first FBP attenuation image to obtain an effective attenuation image; and performing attenuation correction on emission scanning sinogram data from the PET apparatus by using an attenuation sinogram generated based on the effective attenuation image.