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BACKGROUND: While PET using F-FDG is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on F-FDG PET scans. The pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. Furthermore, the addition of adjuvants to vaccines can further enhance the immune response. The presented study was designed to define lymph node activation following administration of the Food and Drug Administration–licensed human papillomavirus vaccines, Cervarix and Gardasil, which contain similar antigens with different adjuvants. METHODS: Twenty-seven women aged 18 to 25 years were randomized to receive either Cervarix or Gardasil in the clinical trial VRC 900. Fifteen subjects participated in the PET/CT portion of the trial and received scans of lymph node activation at prevaccination and “1 week” (8–14 days) and “1 month” (23–36 days) after the first or third vaccination. RESULTS: PET/CT scans revealed that all vaccine recipients had ipsilateral axillary lymph node activity. Three of 4 Cervarix recipients also showed contralateral lymph node activity 1 month after the first vaccination. For both Cervarix and Gardasil, the SUV activity resolved over time, with activity extended up to day 37 after the first and third vaccinations. CONCLUSIONS: Following intramuscular vaccination, there were no major differences between duration of uptake and intensity of SUV between Cervarix and Gardasil recipients in ipsilateral axillary lymph nodes. Contralateral node activation was detected up to 1 month after the first vaccination in Cervarix recipients only, possibly reflecting differences in vaccine adjuvant formulation. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Tom Cruise headlines a spectacular, all-new cinematic version of the legend that has fascinated cultures all over the world since the dawn of civilization: THE MUMMY. Thought safely entombed in a tomb deep beneath the unforgiving desert, an ancient princess (Sofia Boutella of Kingsman: The Secret Service and Star Trek Beyond) whose destiny was unjustly taken from her is awakened in our current day, bringing with her malevolence grown over millennia and terrors that defy human comprehension. From the sweeping sands of the Middle East through hidden labyrinths under modern-day London, The Mummy brings a surprising intensity and balance of wonder and thrills in an imaginative new take that ushers in a new world of gods and monsters. Cruise is joined by a cast including Annabelle Wallis (upcoming King Arthur, television's Peaky Blinders), Jake Johnson (Jurassic World), Courtney B. Vance (TV's American Crime Story: The People V. O.J. Simpson), Marwan Kenzari (The Promise) and Oscar® winner Russell Crowe (Gladiator). The creative team on this action-adventure event is led by director/producer Alex Kurtzman and producer Chris Morgan, who have been instrumental in growing some of the most successful franchises of the past several years—with Kurtzman writing or producing entries in the Transformers, Star Trek and Mission: Impossible series, and Morgan being the narrative engineer of the Fast & Furious saga as it has experienced explosive growth from its third chapter on.  Sean Daniel, who produced the most recent Mummy trilogy, and Sarah Bradshaw (Maleficent) produce alongside Kurtzman and Morgan. Founded in 2014, Positron is a technology studio based in Los Angeles that delivers engineering magic.  The team includes mechatronics engineers, designers, software developers and artists who collaborate together to create VR experiences and products that have never been done before.  Voyager is the first full-motion chair platform designed for cinematic VR. Integrating beautiful design and high-end engineering, it reflects a passion for VR storytelling.  Voyager delivers a completely new level of immersion in VR by providing a comfortable, fully integrated personal VR theater that incorporates gentle motorized yaw and pitch motion, haptic feedback (physical audio powered by Subpac), and specialized seating.  Its unique software and hardware technology integration enables nuanced motion and haptic tracks to be encoded along the featured content's visual and spatial audio tracks.  The chair precisely guides the viewers' attention to points of interest in the experience, while also allowing a viewer-controlled motion mode. Voyager units are available now for select theaters, hotels, concerts, and events that desire to provide a premium VR experience.  For Voyager images please visit Positron Media. The Mummy Prodigium Strike, developed by Swedish game developer Starbreeze Studios, is a captivating VR experience where viewers play as a Prodigium Agent and are tasked with capturing the ancient Princess Ahmanet—while battling hordes of ravens, spiders and the undead.  From a helicopter hovering above to the intense action on the ground, players must protect their fellow agents as The Mummy grows in power, battling to the finish to capture her, or be her slave for eternity.  The Mummy Prodigium Strike utilizes the 210-degree virtual reality headset StarVR® and a unique set of experience-enhancing aids, allowing users to fully transport themselves into the new world of gods and monsters. THE MUMMY arrives in IMAX® and theaters nationwide on Friday, June 9, 2017. To view the original version on PR Newswire, visit:

Chio A.,University of Turin | Pagani M.,CNR Institute of Neuroscience | Pagani M.,Karolinska University Hospital | Agosta F.,Vita-Salute San Raffaele University | And 4 more authors.
The Lancet Neurology | Year: 2014

In the past two decades, structural and functional neuroimaging findings have greatly modified longstanding notions regarding the pathophysiology of amyotrophic lateral sclerosis (ALS). Neuroimaging studies have shown that anatomical and functional lesions spread beyond precentral cortices and corticospinal tracts, to include the corpus callosum; frontal, sensory, and premotor cortices; thalamus; and midbrain. Both MRI and PET studies have shown early and diffuse loss of inhibitory cortical interneurons in the motor cortex (increased levels of functional connectivity and loss of GABAergic neurons, respectively) and diffuse gliosis in white-matter tracts. In ALS endophenotypes, neuroimaging has also shown a diverse spreading of lesions and a dissimilar impairment of functional and structural connections. A possible role of PET in the diagnosis of ALS has recently been proposed. However, most neuroimaging studies have pitfalls, such as a small number and poor clinical characterisation of patients, absence of adequate controls, and scarcity of longitudinal assessments. Studies involving international collaborations, standardised assessments, and large patient cohorts will overcome these shortcomings and provide further insight into the pathogenesis of ALS. © 2014 Elsevier Ltd.

Ectopic thyroid tissue (ETT) refers to all cases in which the thyroid gland is present at a location other than its usual site. The prevalence of ETT is approximately one per 100,000 to 300,000 persons and is reported to occur in one in 4,000 to 8,000 patients with thyroid disease. Multiple ectopia of thyroid is extremely rare. Multiple ectopia in the presence of orthotopic thyroid gland is extremely rare. We report a 13-year-old boy with stunted growth and developmental delay caused due to acquired hypothyroidism. Technetium scan performed as per management protocol identified dual ectopia of thyroid. The role of hybrid Single-Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT) in the localization of the sites of ETT is also highlighted.

Guerard F.,NCI Inc | Lee Y.-S.,U.S. National Institutes of Health | Tripier R.,CNRS Chemistry Laboratory | Szajek L.P.,Positron | And 2 more authors.
Chemical Communications | Year: 2013

Single crystal X-ray diffraction shows that Zr(iv) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr. © The Royal Society of Chemistry 2013.

Penile cancer is rare cancer. While inguinal and pelvic nodal metastasis is common, distant metastasis is rare. We here present the interesting case of a 59-year-old male patient with penile carcinoma, previously treated with penectomy and inguinal lymphadenectomy 10 years earlier. He presented with bone pains and given history of malignancy he was referred for an 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). PET/CT demonstrated multiple 18F-FDG avid bone and lung metastases. No locoregional disease was seen. Biopsy from a lung nodule confirmed the diagnosis, and the patient was started on palliative chemotherapy. © 2016 Indian Journal of Nuclear Medicine | Published by Wolters Kluwer - Medknow.

Smith J.F.,U.S. National Institutes of Health | Pillai A.,U.S. National Institutes of Health | Chen K.,Arizona State University | Chen K.,Positron | Horwitz B.,U.S. National Institutes of Health
NeuroImage | Year: 2010

Dynamic connectivity networks identify directed interregional interactions between modeled brain regions in neuroimaging. However, problems arise when the regions involved in a task and their interconnections are not fully known a priori. Objective measures of model adequacy are necessary to validate such models. We present a connectivity formalism, the Switching Linear Dynamic System (SLDS), that is capable of identifying both Granger-Geweke and instantaneous connectivity that vary according to experimental conditions. SLDS explicitly models the task condition as a Markov random variable. The series of task conditions can be estimated from new data given an identified model providing a means to validate connectivity patterns. We use SLDS to model functional magnetic resonance imaging data from five regions during a finger alternation task. Using interregional connectivity alone, the identified model predicted the task condition vector from a different subject with a different task ordering with high accuracy. In addition, important regions excluded from a model can be identified by augmenting the model state space. A motor task model excluding primary motor cortices was augmented with a new neural state constrained by its connectivity with the included regions. The augmented variable time series, convolved with a hemodynamic kernel, was compared to all brain voxels. The right primary motor cortex was identified as the best region to add to the model. Our results suggest that the SLDS model framework is an effective means to address several problems with modeling connectivity including measuring overall model adequacy and identifying important regions missing from models. © 2009.

Positron emission tomography, most commonly with 18F-fluorodeoxyglucose, is being used for evaluation of tumour response to therapy. Limitations of this method are associated with (1) fluorodeoxyglucose pharmacokinetic properties, (2) the detection system, (3) discrepancies between metabolic and anatomic images, and (4) acquisition standardization. Response to therapy may be evaluated with qualitative (Deauville score), semiquantitative (standardised uptake value), and quantitative methods (European Organization for Research and Treatment of Cancer; Positron Emission Tomography Response Criteria in Solid Tumours). Methods under evaluation include metabolic tumour volume, total lesion glycolysis, and heterogeneity of fluorodeoxyglucose uptake. The development of positron emission tomography scanners that have larger fields of view may facilitate tumour assessment based on kinetic modelling. Increased clinical use of these methods will depend on the development and validation of intuitive and simple analytic tools. © 2014, The Author(s).

An attenuation correction method and device for an image in a PET system. The method includes: acquiring transmission scanning sinogram data from a PET apparatus; reconstructing the transmission scanning sinogram data with Bayesian model-based Ordered Subset Expectation Maximization (OSEM-B) algorithm and Filtered Back Projection (FBP) algorithm, to obtain an OSEM-B attenuation image and a first FBP attenuation image respectively; performing a weighted calculation on the OSEM-B attenuation image and the first FBP attenuation image to obtain an effective attenuation image; and performing attenuation correction on emission scanning sinogram data from the PET apparatus by using an attenuation sinogram generated based on the effective attenuation image.

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