Time filter

Source Type

Vila Real de Santo António, Portugal

Almeida Goncalves J.C.,Portuguese Institute of Oncology
Giornale Italiano di Dermatologia e Venereologia | Year: 2011

Aim. Cryosurgery with liquid nitrogen (LN) is a safe and effective method to treat skin cancer. With the correct protocol, its efficacy is extended to advanced and inoperable tumors. The aim of this study was to report the author's experience in the treatment of advanced squamous-cell carcinomas of the extremities. Methods. Forty-eight patients (31 women and 17 men; mean age of 79 years) with 50 advanced squamous-cell carcinomas (SCC) of the extremities were treated with open and thick LN spray -two freeze-thaw cycles - reaching a temperature around -50 °C inside the tumor, but not less than -20 °C in the tumor limits and the underlying structures. Temperature monitoring was made by thermocouples. All cases in this series were treated by the author. Results. The overall cure rate was 88%, with follow-up between 1 and 8 years (mean of 2.64 years). Conclusion. This cryosurgical method is an effective treatment for advanced cancers of the extremities, yielding a high cure rate and, in many cases, preventing amputation. Source

Goncalves F.,Portuguese Institute of Oncology
American Journal of Hospice and Palliative Medicine | Year: 2014

Aim: To develop a screening tool that was short, not time consuming but able to detect the patients' main problems at admission. Methods: A list of 106 symptoms/problems derived from a review of the literature was created and shortened using a Delphi process. Results: Thirteen experts scored each item with a numeric rating scale of 0 to 10 for relevance. After 3 rounds, the list was shortened to 14 items: general question-what bothers you the most? symptoms/problems-pain, lack of appetite, vomiting, tiredness/fatigue, nausea, constipation, shortness of breath, depression, anxiety, difficulty sleeping; activity (dressing, washing, etc); support from family/friends; and well-being. Conclusion: The final tool is short and seems to include the relevant items that would make it useful for clinical practice. © The Author(s) 2013. Source

Canavarro M.C.,University of Coimbra | Pereira M.,University of Coimbra | Simoes M.R.,University of Coimbra | Pintassilgo A.L.,Portuguese Institute of Oncology
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV | Year: 2011

The assessment of quality of life (QOL) in HIV infection has emerged as being vital to research and clinical practice. This assessment is also a challenge due to the specific characteristics of the infection, the increased availability of therapeutics, as well as the epidemiological variability inherent to HIV infection. The purpose of this study was to investigate the psychometric properties of the European Portuguese version of the World Health Organization's QOL Instrument in HIV Infection (WHOQOL-HIV) and to test its performance in a sample of HIV-infected patients. The European Portuguese version of WHOQOL-HIV was administered in a sample of 200 HIV-positive patients. The patients also completed the Portuguese versions of Beck Depression Inventory (BDI) and Brief Symptom Inventory (BSI). The WHOQOL-HIV showed quite an acceptable internal consistency (Cronbach's ranged from 0.86 to 0.95 across domains). Convergent validity with BDI and BSI was satisfactory for all domains (all r>0.50; p<0.001). Moreover, correlations between domains and between domains and overall QOL were all statistically significant (p<0.001). The reliability and validity studies of the European Portuguese version of the WHOQOL-HIV revealed good psychometric characteristics, which allows for the use of this version of WHOQOL in our country, and cross-cultural comparability. © 2011 Taylor & Francis. Source

Fontes A.S.,Joaquim Urbano Hospital Porto Hospital Center | Goncalves J.F.,Portuguese Institute of Oncology
American Journal of Hospice and Palliative Medicine | Year: 2014

Pain is a common and debilitating symptom of human immunodeficiency virus (HIV) disease, although it is often underestimated and undertreated, especially in HIV-infected intravenous drug users. It is more likely to occur in the later stages of the HIV disease, where it assumes particular significance, especially in terminally ill patients. However, its successful management is possible, though the goal of effective therapy is hampered by the side effects of highly active antiretroviral therapy and drug-drug interactions. In order to appraise these issues, a search in MEDLINE database was conducted. Book reviews and a search on relevant Web sites were also included. Treatment of HIV is itself very complex and becomes even more difficult when palliative therapy is added. Protease inhibitors, mainly ritonavir, and nonnucleoside reverse transcriptase inhibitors have higher interaction potential, due to their inducer or inhibitory actions on cytochrome P450, posing a risk when coadministered with palliative treatments; so, better outcomes can be achieved with knowledge of pharmacological aspects. © The Author(s) 2013. Source

Almeida-Goncalves J.C.,International Society of Cryosurgery | Almeida-Goncalves J.C.,Portuguese Institute of Oncology
Journal of Surgical Oncology | Year: 2012

Background and Objective Malignant degeneration of pilonidal sinuses of the sacrococcygeal region is rare but quite serious, as the tumor soon perforates the sacral fascia and becomes adherent to the irregular posterior aspect of the sacrum, making it very difficult, if not impossible, to remove all neoplastic tissue by conventional surgery, hence the high recurrence rate and poor prognosis. A new cryosurgical technique to treat advanced sacrococcygeal pilonidal cancer is herein presented. Materials and Methods Seven men aged 30-75 (mean: 54.4 years) with advanced squamous-cell carcinomas (four primary, three recurrent) arising in sacrococcygeal pilonidal sinuses were treated with open and thick liquid nitrogen spray-two freeze-thaw cycles. Temperature monitoring was made by thermocouples. Results Local eradication was achieved in all cases; one patient, however, died of metastatic disease 10 months after treatment, without local recurrence. One patient had a recurrence, or a new tumor, 8 years after treatment and was again submitted to aggressive cryosurgery followed by plastic surgery. He was followed for 14 years without recurrence. The follow-up of the remaining six patients ranges between 7 and 18 years. Conclusion To the author's knowledge, this is the first series of carcinomas of sacrococcygeal pilonidal sinuses successfully treated by cryosurgery. J. Surg. Oncol. 2012; 106:504-508. © 2012 Wiley Periodicals, Inc. Copyright © 2012 Wiley Periodicals, Inc. Source

Discover hidden collaborations