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Madrid, Spain

Jimenez Caballero P.E.,San Pedro de Alcantara Hospital | Jimenez Caballero P.E.,Portal Inc. | Portilla Cuenca J.C.,San Pedro de Alcantara Hospital | Casado Naranjo I.,San Pedro de Alcantara Hospital
Journal of Headache and Pain | Year: 2011

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome is a rare headache syndrome classified among the trigeminal autonomic cephalalgias. It is usually idiopathic, although infrequent secondary forms have been described. Recently, the term short-lasting unilateral headache with cranial autonomic symptoms (SUNA) has been defined by the International Headache Society (ICHD-2) as similar to SUNCT with less prominent absent conjunctival injection and lacrimation. We report a patient with paroxysmal orbito-temporal pains, phenotypically suggesting SUNA, secondary to epidermoid cyst in the cerebellopontine angle which disappeared after tumor resection. Neuroimaging should be considered in all patients with SUNA, notably in those with atypical presentation as our patient who presented on examination trigeminal hypoesthesia and tinnitus. Realization of a brain MRI would rule out injuries that causes this type of syndrome. © 2011 The Author(s).

Dabritz J.,University of Munster | Dabritz J.,The Interdisciplinary Center | Dabritz J.,Murdoch Childrens Research Institute | Langhorst J.,Internal and Integrative Medicine | And 7 more authors.
Inflammatory Bowel Diseases | Year: 2013

Background: Prediction of inflammatory bowel disease relapse has important implications for therapeutic strategies. Fecal S100A12 has been reported as a novel marker of intestinal inflammation. The objective was to investigate the utility of S100A12 as a marker for the confirmation of stable remission and prediction of relapses. Methods: We consecutively included 147 adults and 34 children with Crohn's disease (n = 61) or ulcerative colitis (n = 120). Over a 3-year period, we collected 686 stool samples and 861 serum samples during regular follow-up visits. S100A12 and calprotectin levels were measured by an enzyme-linked immunoassay. Results: Fecal S100A12 correlated with S100A12 serum levels, other laboratory markers, as well as disease activity, location, and behavior. Fecal S100A12 levels in the relapse group differed significantly from those of the nonrelapse group. A baseline fecal S100A12 level of >0.5 mg/kg was significantly associated with disease relapse within 18 months. Time course analysis of fecal S100A12 before and after relapse showed a clear increase of S100A12 concentrations up to 6 months before clinical relapse. At 0.43 mg/kg, the sensitivity and specificity of S100A12 for predicting relapse already 8 to 12 weeks earlier were 70% and 83%, respectively. Conclusions: Regular measurements of fecal S100A12 levels reliably detect inflammatory bowel disease relapse at an early stage, which makes the test a promising noninvasive tool for monitoring and optimizing therapy, and may reduce the need for invasive investigations during disease follow-up. Copyright ©; 2013 Crohn's & Colitis Foundation of America, Inc.

Ryabov Y.,Portal Inc.
Proteins: Structure, Function and Bioinformatics | Year: 2015

In this work, we formulate a closed-form solution of the model of a semirigid molecule for the case of fluctuating and reorienting molecular electric dipole moment. We illustrate with numeric calculations the impact of protein domain motions on dielectric spectra using the example of the 128 kDa protein dimer of Enzyme I. We demonstrate that the most drastic effect occurs for situations when the characteristic time of protein domain dynamics is comparable to the time of overall molecular rotational diffusion. We suggest that protein domain motions could be a possible explanation for the high-frequency contribution that accompanies the major relaxation dispersion peak in the dielectric spectra of protein aqueous solutions. We propose that the presented computational methodology could be used for the simultaneous analysis of dielectric spectroscopy and nuclear magnetic resonance data. © 2015 Wiley Periodicals, Inc.

Portal Inc. | Date: 2014-04-23

Providing temporary use of on-line non-downloadable software accessed via internet as a service to store, manage, track, analyze, and report data in the field of customer orders, shipments, invoices, payments, returns, and inventory positions, and for customizing computer application user interfaces; Computer services, namely, designing, developing, and maintaining computer software applications for others and consulting services related to all of the foregoing.

Portal Inc. | Date: 2014-08-15

Tents. On-line retail store featuring tents, trailers, clothing and hats. Conducting camping tours for others.

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