Time filter

Source Type

Kyaukpadaung, Myanmar

Choi J.,Seoul National University | Cho J.Y.,Sungkyunkwan University | Kim Y.-D.,Hallym University | Htwe K.M.,Popa Mountain Park | And 4 more authors.
Natural Product Sciences

Diospyros burmanica Kurz. is an evergreen deciduous tree distributed in Mandalay of Myanmar, which belongs to the family of Ebenaceae. In Myanmar, it has been used to treat diarrhea, diabetes, diabetes and also as lumbers. In this study, seven flavonoids (1 - 7), a phenolic compound (8), and five triterpenes (9 - 13) were isolated from the barks of D. burmanica and their chemical structures were elucidated. Isolates were identified to be (+)catechin (1), (+)-catechin 3-O-a-L-rhamnopyranoside (2), (+)-catechin 3-O-gallate (3), (-)-epicatechin (4), (-)epicatechin 3-O-gallate (5), (+)-afzelechin 3-O-a-L-rhamnopyranoside (6), (+)-2,3-trans-dihydrokaempferol 3-O-αL-rhamnopyranoside (7), methyl gallate (8), lupeol (9), methyl lup-20(29)-en-3-on-28-oate (10), ß-amyrin (11), αamyrin (12), 3ß-hydroxy-D:B-friedo-olean-5-ene (13) through MS,1H NMR and13C NMR spectroscopic evidences. © 2015, Korean Society of Pharmacognosy. All rights reserved. Source

Kim E.,Sungkyunkwan University | Yoon K.D.,Catholic University of Korea | Lee W.-S.,Seoul National University | Yang W.S.,Sungkyunkwan University | And 9 more authors.
Journal of Ethnopharmacology

Ethnopharmacological relevance Codariocalyx motorius (Houtt.) H. Ohashi (Fabaceae) is one of several ethnopharmacologically valuable South Asian species prescribed as an herbal medicine for various inflammatory diseases. Due to the lack of systematic studies on this plant, we aimed to explore the inhibitory activity of Codariocalyx motorius toward inflammatory responses using its ethanolic extract (Cm-EE). Materials and methods Lipopolysaccharide (LPS)-treated macrophages and a HCl/EtOH-induced gastritis model were used for evaluation of the anti-inflammatory activity of Cm-EE. HPLC and spectroscopic analysis were employed to identify potential active components. Mechanistic approaches to determine target enzymes included kinase assays, reporter gene assays, and overexpression of target enzymes. Results Cm-EE strongly suppressed nitric oxide (NO) and prostaglandin E2 (PGE2) release. Cm-EE-mediated inhibition was observed at the transcriptional level in the form of suppression of NF-κB (p65) translocation and activation. This extract also lowered the levels of phosphorylation of Src and Syk, their kinase activity, and their formation of signalling complexes by binding to the downstream enzyme p85/PI3K. In accord with these findings, the phosphorylation of p85 induced by overexpression of Src or Syk was also diminished by Cm-EE. Orally administered Cm-EE clearly inhibited gastritic ulcer formation and the phosphorylation of IκBα and Src in HCl/EtOH-treated stomachs of mice. By phytochemical analysis, luteolin and its glycoside, apigenin-7-O-glucuronide, and scutellarein-6-O-glucuronide were identified as major components of Cm-EE. Among these, it was found that luteolin was able to strongly suppress NO and PGE2 production under the same conditions. Conclusion Syk/Src-targeted inhibition of NF-κB by Cm-EE could be a major anti-inflammatory mechanism contributing to its ethno pharmacological role as an anti-inflammatory herbal medicine. © 2014 Elsevier Ireland Ltd. All rights reserved. Source

Jung M.,Catholic University of Korea | Choi J.,Seoul National University | Chae H.-S.,Dongguk University | Cho J.Y.,Sungkyunkwan University | And 6 more authors.

A novel isoflavone glycoside, peseudobatigenin 7- O-[β-D-apiofuranosyl-(1''''→5''')-O-β-D-apiofuranosyl-(1'''→6'')]-β- D-glucopyranoside, namely sympracemoside (1), was isolated from the aerial parts of Symplocos racemosa along with 15 known flavonoids (2-16). Their structures were characterized by Q-TOF mass, optical rotation, UV, 1D and 2D-NMR spectroscopic data. Compounds 3, 9, 16 showed moderate inhibitory activities against NO production with IC50 value of 88.2, 42.1 and 74.3 μM, respectively. © 2014 by the authors licensee MDPI Basel Switzerland. Source

Kim A.,Catholic University of Korea | Choi J.,Seoul National UniversitySeoul | Htwe K.M.,Popa Mountain Park | Chin Y.-W.,Dongguk University | And 2 more authors.

Abstract Phytochemical investigations of the aerial parts of Acacia pennata (Mimosaceae) from Myanmar led to the isolation of five flavonoid glycosides and six known compounds. The new compounds were identified as (2R, 3S)-3,5,7-trihdyroxyflavan-3-O-α-l-rhamnopyranoside, (2S)-5,7-dihydroxyflavan-7-O-β-d-glucopyranoside-(4α → 8)-epiafzelechin-3-O-gallate, (2R)-4′,7-dihydroxyflavan-(4α → 8)-(2R, 3S)-3,5,7-trihdyroxyflavan-3″-O-α-l-rhamnopyranoside, 5,7-dihydroxyflavone 6-C-β-boivinopyranosyl-7-O-β-d-glucopyranoside, and 5,7-dihydroxyflavone 7-O-β-d-glucopyranosyl-8-C-β-boivinopyranoside based on interpretation of spectroscopic data. © 2015 Elsevier Ltd. Source

Choi J.,Seoul National University | Cho J.Y.,Sungkyunkwan University | Choi S.J.,Catholic University of Korea | Jeon H.,Catholic University of Korea | And 6 more authors.

Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-D-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-D-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM. © 2015 by the authors; licensee MDPI. Source

Discover hidden collaborations