Suresh Kumar G.V.,P.A. College |
Rajendra Prasad Y.,Andhra University |
Chandrashekar S.M.,Poornaprajna Institute of Scientific Research PPISR Poornaprajnapura
Medicinal Chemistry Research | Year: 2013
A series of novel 4-isopropylthiazol-4-phenyl-1,2,4-triazol derivatives, N′-(substituted benzylidene)-2-(5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1, 2,4-triazol-3-ylthio)acetohydrazides 4a-e, 4-isopropylthiazol-2-yl-4′- phenyl-4′H-1′, 2′,4′-triazol-3′-ylthio (substituted methyl benzylidene) acetohydrazides 5a-f, 3-(4-isopropylthiazol-2- yl)-4-phenyl-5-(5-substituted-1,3,4-oxadiazol-2-ylthio)-4H-1,2,4-triazole derivatives 6a-f and N-acetyl-5′-(4-isopropylthiazol-2-yl)-4′- phenyl-4′H-1,2,4-triazol-3′-ylthio) acetohydrazide 7 were synthesized and characterized by spectroscopy, elemental, and mass spectral analysis. These compounds were evaluated for their preliminary in vitro antibacterial, antifungal, and antitubercular activity against Mycobacterium tuberculosis (M. tuberculosis) H37Rv strain by broth dilution assay method. All the compounds exhibited moderate to significant antibacterial and antifungal activities. Results of the antitubercular screening against Mycobacterium tuberculosis H37Rv showed that compounds 4c and 6c exhibited good antitubercular activity when compared with first line drug isoniazid. © 2012 Springer Science+Business Media, LLC.