Yan L.,Pony Testing Technology Co. |
Wang Y.,Capital Normal University |
Yu Q.,Beijing Supertrack Medical Technology Develop Ltd.
Zhongguo Zhongyao Zazhi | Year: 2011
Objective: To analyze p-coumaril acid, trans-6-O-p-coumaroyl scandoside methyl ester and its metabolites in rat plasma after intragastric administration of exocarpium Diffusa effective extracts. Method: Rat blood samples were collected 1. 0 h after oral administration of 0.4 g·kg-1 exocarpium Diffusa effective extracts, and then were analyzed by using HPLC-Q-TOF-MS. Result: In rat plasma, only one metabolite was detected. The structure was identified by reference substance to be p-coumaril acid. Conclusion: The methyl glucoside metabolite in rat from the main component parts of trans-6-O-p-coumaroyl scandoside methyl ester droppings of vines in Diffusa effective extracts is p-coumaril acid. This experiment provides a theortical basis for studying chemical compositions and pharmacodynamic action of Diffusa.