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PubMed | Pony Testing Technology Co.
Type: Evaluation Studies | Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | Year: 2011

To analyze p-coumaril acid, trans-6-O-p-coumaroyl scandoside methyl ester and its metabolites in rat plasma after intragastric administration of exocarpium Diffusa effective extracts.Rat blood samples were collected 1.0 h after oral administration of 0.4 g x kg(-1) exocarpium Diffusa effective extracts, and then were analyzed by using HPLC-Q-TOF-MS.In rat plasma, only one metabolite was detected. The structure was identified by reference substance to be p-coumaril acid.The methyl glucoside metabolite in rat from the main component parts of trans-6-O-p-coumaroyl scandoside methyl ester droppings of vines in Diffusa effective extracts is p-coumaril acid. This experiment provides a theortical basis for studying chemical compositions and pharmacodynamic action of Diffusa.


Yan L.,Pony Testing Technology Co. | Wang Y.,Capital Normal University | Yu Q.,Beijing Supertrack Medical Technology Develop Ltd.
Zhongguo Zhongyao Zazhi | Year: 2011

Objective: To analyze p-coumaril acid, trans-6-O-p-coumaroyl scandoside methyl ester and its metabolites in rat plasma after intragastric administration of exocarpium Diffusa effective extracts. Method: Rat blood samples were collected 1. 0 h after oral administration of 0.4 g·kg-1 exocarpium Diffusa effective extracts, and then were analyzed by using HPLC-Q-TOF-MS. Result: In rat plasma, only one metabolite was detected. The structure was identified by reference substance to be p-coumaril acid. Conclusion: The methyl glucoside metabolite in rat from the main component parts of trans-6-O-p-coumaroyl scandoside methyl ester droppings of vines in Diffusa effective extracts is p-coumaril acid. This experiment provides a theortical basis for studying chemical compositions and pharmacodynamic action of Diffusa.

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