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Santiago, Chile

The Pontifical Catholic University of Chile is one of the six Catholic Universities existing in the Chilean university system and one of the two Pontifical Universities in the country, along with the Pontifical Catholic University of Valparaíso. It is also one of Chile's oldest universities and one of the most recognized educational institutions in Latin America. It ranks 1st in South America by QS ranking. Wikipedia.

Quiroga T.,Pontifical Catholic University of Chile
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | Year: 2012

Congenital mild bleeding disorders (MBDs) are very prevalent and are the source of frequent diagnostic problems. Most MBDs are categorized as disorders of primary hemostasis (ie, type 1 VWD and platelet function disorders), but mild or moderate deficiencies of clotting factors and some rare hyperfibrinolytic disorders are also included. These patients have abnormal bleeding from the skin and mucous membranes, menorrhagia, and disproportionate hemorrhages after trauma, invasive procedures, and surgery. This review addresses the main problems that physicians and hemostasis laboratories confront with the diagnosis of these patients, including: discerning normal/appropriate from pathological bleeding, the role and yield of screening tests, the lack of distinctive bleeding pattern among the different diseases, the inherent difficulties in the diagnosis of type 1 VWD and the most common platelet functional disorders, improvements in assays to measure platelet aggregation and secretion, and the evidence that most of the patients with MBDs end up without a definite diagnosis after exhaustive and repeated laboratory testing. Much research is needed to determine the pathogenesis of bleeding in MBD patients. Better standardization of current laboratory assays, progress in the knowledge of fibrinolytic mechanisms and their laboratory evaluation, and new understanding of the factors contributing to platelet-vessel wall interaction, along with the corresponding development of laboratory tools, should improve our capacity to diagnose a greater proportion of patients with MBDs. Source

Nunez R.E.,University of California at San Diego | Cornejo C.,Pontifical Catholic University of Chile
Cognitive Science | Year: 2012

The Aymara of the Andes use absolute (cardinal) frames of reference for describing the relative position of ordinary objects. However, rather than encoding them in available absolute lexemes, they do it in lexemes that are intrinsic to the body: nayra ("front") and qhipa ("back"), denoting east and west, respectively. Why? We use different but complementary ethnographic methods to investigate the nature of this encoding: (a) linguistic expressions and speech-gesture co-production, (b) linguistic patterns in the distinct regional Spanish-based variety Castellano Andino (CA), (c) metaphorical extensions of CA's spatial patterns to temporal ones, and (d) layouts of traditional houses. Findings indicate that, following fundamental principles of Aymara cosmology, people, objects, and land-as a whole-are conceived as having an implicit canonical orientation facing east, a primary landmark determined by the sunrise. The above bodily based lexicalizations are thus linguistic manifestations of a broader macro-cultural worldview and its psycho-cognitive reality. © 2012 Cognitive Science Society, Inc.. Source

Pisconti A.,University of Colorado at Boulder | Cornelison D.D.W.,University of Missouri | Olguin H.C.,University of Colorado at Boulder | Olguin H.C.,Pontifical Catholic University of Chile | And 2 more authors.
Journal of Cell Biology | Year: 2010

Skeletal muscle postnatal growth and repair depend on satellite cells and are regulated by molecular signals within the satellite cell niche. We investigated the molecular and cellular events that lead to altered myogenesis upon genetic ablation of Syndecan-3, a component of the satellite cell niche. In the absence of Syndecan-3, satellite cells stall in S phase, leading to reduced proliferation, increased cell death, delayed onset of differentiation, and markedly reduced numbers of Pax7+ satellite cells accompanied by myofiber hypertrophy and an increased number of centrally nucleated myofibers. We show that the aberrant cell cycle and impaired selfrenewal of explanted Syndecan-3-null satellite cells are rescued by ectopic expression of the constitutively active Notch intracellular domain. Furthermore, we show that Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-α-converting enzyme (TACE) and signal transduction. Together, our data support the conclusion that Syndecan-3 and Notch cooperate in regulating homeostasis of the satellite cell population and myofiber size. © 2010 Pisconti et al. Source

Sagaris L.,Pontifical Catholic University of Chile
Journal of Transport Geography | Year: 2014

Twentieth century citizen "revolts" against urban highway projects have influenced thinking about public transport (Toronto, Vancouver, New York), governance (Portland), and cycling (The Netherlands) to this day. Less is known, however, about how these emerge in developing countries, and what they can tell us about citizens' role in innovation to achieve more sustainable transport systems. This case study examines a social movement that emerged in opposition to the country's first major highway concession, in Santiago, Chile (1997), challenging and changing urban planning paradigms. In 2000, the anti-highway campaign founded a citizen institution, Living City (Ciudad Viva). Twelve years later, it has become a prize-winning, citizen-led planning institution.Although the role of citizen participation in improving transport systems has become increasingly recognized in recent years, it still tends to be rather ritualistic. This experience offers insight into how strategic approaches to participation can reinforce the role of self-organizing civil society organizations in introducing innovation into existing systems. Findings suggest that traditional large movements, which are mainly useful for one-way communication of information, require support from small groups able to deliberate in a transformative sense, with more attention paid to how new consensuses can be transmitted through the relational networks of those involved. Moreover, this experience suggests that thinking about citizens as planners in their own right, rather than as mere participants at specific points in a planning process, opens the way to more effective strategies for innovating in transport, to address the social, environmental, and other challenges humanity faces today. © 2014 Elsevier Ltd. Source

Goold B.,University of British Columbia | Loader I.,University of Oxford | Thumala A.,Pontifical Catholic University of Chile
British Journal of Criminology | Year: 2013

Why do certain security goods become banal (while others do not)? Under what conditions does banality occur and with what effects? In this paper, we answer these questions by examining the story of closed circuit television cameras (CCTV) in Britain. We consider the lessons to be learned from CCTV's rapid - but puzzling - transformation from novelty to ubiquity, and what the banal properties of CCTV tell us about the social meanings of surveillance and security. We begin by revisiting and reinterpreting the historical process through which camera surveillance has diffused across the British landscape, focusing on the key developments that encoded CCTV in certain dominant meanings (around its effectiveness, for example) and pulled the cultural rug out from under alternative or oppositional discourses. Drawing upon interviews with those who produce and consume CCTV, we tease out and discuss the family of meanings that can lead one justifiably to describe CCTV as a banal good. We then examine some frontiers of this process and consider whether novel forms of camera surveillance (such as domestic CCTV systems) may press up against the limits of banality in ways that risk unsettling security practices whose social value and utility have come to be taken for granted. In conclusion, we reflect on some wider implications of banal security and its limits. © The Author 2013. Published by Oxford University Press on behalf of the Centre for Crime and Justice Studies (ISTD). All rights reserved. Source

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