Pondicherry UniversityPondicherry

Puducherry, India

Pondicherry UniversityPondicherry

Puducherry, India
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Nakkala J.R.,Pondicherry UniversityPondicherry | Mata R.,Pondicherry UniversityPondicherry | Sadras S.R.,Pondicherry UniversityPondicherry
Journal of Colloid and Interface Science | Year: 2017

Green synthesis of nanoparticles using plants is gaining much interest in recent years. Anyway, intricate details on the role of phytochemicals involved in capping and stabilization of nanoparticles in diminishing toxicity and enhancing therapeutic potential are required. In this study, Ficus religiosa silver nanoparticles (FRAgNPs) were synthesized using Ficus religiosa leaf extract (FRLE) and characterized. The FRAgNPs showed good antibacterial activity and also cytotoxic effect in different cancer cell lines. Induction of apoptotic cell death was confirmed by various staining techniques, increased expression of cleaved caspases-8, 9, 3, lamin, PARP and oxidative stress markers in A549 and Hep2 cells. The in vivo studies performed in rats revealed significant increase in serum levels of AST, ALT, and LDH, TNF-α and IL-6 on day 29 following oral administration of FRAgNPs. However, these levels reverted back to normal at the end of wash out period on day 89. ICP-OES analysis revealed accumulation of silver in liver, brain and lungs on day 29 with respective concentration of 4.77, 3.94 and 3.043 μg/g tissue. However, complete elimination of silver was observed on day 89. Histological analysis performed in vital organs indicated pathological changes only in liver which was also normalized after 89 days. © 2017 Elsevier Inc.


Kharkongor C.,Pondicherry UniversityPondicherry | Chithralekha T.,Pondicherry UniversityPondicherry | Varghese R.,Pondicherry UniversityPondicherry
Advances in Intelligent Systems and Computing | Year: 2017

The internet of thing (IOT) is an upheaval of traditional internet. It is new revolution that not only allows transmission and exchange of data but also communication between the physical objects in the real world. These heterogeneous devices are pervasive, ubiquitous in nature that changes dynamically and frequently. Mostly, these devices are low-powered devices and have less computation power and capacity. Traditional routing techniques in ad hoc network do not take security and energy into consideration. To extend the lifetime of the network, the energy supply and consumption of the node is an important aspect. The routing of the packet should be as such that even the low-powered devices have the ability to receive and transmit the packet. The presence of malicious node will make the network more susceptible to the different attacks and threat. To overcome this problem, an energy-efficient routing protocol with a centralized controller is integrated with IOT devices. © Springer Nature Singapore Pte Ltd. 2017.


Ganeshraja A.S.,Pondicherry UniversityPondicherry | Ganeshraja A.S.,CAS Dalian Institute of Chemical Physics | Thirumurugan S.,Pondicherry UniversityPondicherry | Rajkumar K.,Pondicherry UniversityPondicherry | And 2 more authors.
Journal of Alloys and Compounds | Year: 2017

Nickel(II) imidazole-anatase composites with room temperature ferromagnetism and good photocatalytic activity were prepared by a simple adsorption method using [Ni(1-MeIm)6]Cl2·H2O complex and anatase TiO2 as starting materials in aqueous medium. The deposition of the surface species were elucidated by various conventional techniques. Ferromagnetic behavior was observed from vibrating sample magnetometer at room temperature. This composite has good visible light absorption ability than pristine TiO2. The adsorption and photocatalytic activity of the composite catalysts were evaluated by choosing methylene blue (MB) as organic pollutant under visible light irradiation. We first time report the Ni(II)-imidazole complex deposited on the anatase semiconductor with good photocatalytic and magnetic properties. This is expected to open up a general method for the synthesis of other transition metal loaded metal oxide semiconductor photocatalysts. © 2017 Elsevier B.V.


Antony J.M.R.,Sathyabama University | Parthiban L.,Pondicherry UniversityPondicherry
International Journal of Applied Engineering Research | Year: 2015

Global optimization based clustering methods are widely studied and used in data mining, which is current dynamic research of real globe problems. Fuzzy C-Means (FCM) algorithm is the most commonly used clustering technique, because it is very efficient, and easy to execute in most of the situation. But, it easily suffers from initialization problem and also easily rapt in local optima. This problem can be overcome by a new evolutionary algorithm called Biogeography Based Optimization (BBO), which is a population based evolutionary method motivated by migration mechanism. Biogeography Based Optimization (BBO) is basically a science of physical allocation of the biological species. The models of biogeography explain how an individual arises, immigrates and emigrates from one environment to another and gets eliminated. This paper proposed a hybrid FCM clustering method based on BBO, which uses the merits of both algorithms. The efficiency of this algorithm is verified and tested using a set of bench mark data and compared with other algorithms like FCM and K-means. The result shows that the proposed method is feasible to solve data clustering problems. © Research India Publications.


Athithan V.,Pondicherry UniversityPondicherry | Srikumar K.,Pondicherry UniversityPondicherry
Chemico-Biological Interactions | Year: 2017

Plant steroids are being recognized as influential secondary bio factors, assimilating in animal tissues through diet and affecting their cellular metabolic function to varying degree. They modulate catalytic and signaling functions in mammalian cells, affecting cellular homeostasis. The effect of phyto brassinosteroid ketoisoform 28-homocastasterone (28-HC), was assessed for its influence on blood glucose, plasma lipid and selective signal marker levels in normal and diabetic male wistar rat models. A 15 day oral feed regimen employing the experimental rat, noted that circulating blood glucose, cholesterol and triglyceride level in diabetic rat were markedly reduced by this compound. This study confirmed that the keto form had anti-hyperglycemic and anti-lipidemic potency associated with it and was available to man and animals in their diet. Western blots of marker protein, PCR amplicons of marker mRNA expressions and In Silico studies suggested that 28-HCeffect is being mediated through LxR molecular operatives in the rat cell. © 2017 Elsevier B.V.


Chandramohan D.,Pondicherry UniversityPondicherry | Vengattaraman T.,Pondicherry UniversityPondicherry | Dhavachelvan P.,Pondicherry UniversityPondicherry
Journal of King Saud University - Engineering Sciences | Year: 2017

This paper spotlights privacy and its obfuscation issues of intellectual, confidential information owned by insurance and finance sectors. Privacy risk in business era if authoritarians misuse secret information. Software interruptions in steeling digital data in the name of third party services. Liability in digital secrecy for the business continuity isolation, mishandling causing privacy breaching the vicinity and its preventive phenomenon is scrupulous in the cloud, where a huge amount of data is stored and maintained enormously. In this developing IT-world toward cloud, users privacy protection is becoming a big question, albeit cloud computing made changes in the computing field by increasing its effectiveness, efficiency and optimization of the service environment etc, cloud users data and their identity, reliability, maintainability and privacy may vary for different CPs (cloud providers). CP ensures that the user's proprietary information is maintained more secretly with current technologies. More remarkable occurrence is even the cloud provider does not have suggestions regarding the information and the digital data stored and maintained globally anywhere in the cloud. The proposed system is one of the obligatory research issues in cloud computing. We came forward by proposing the Privacy Preserving Model to Prevent Digital Data Loss in the Cloud (PPM–DDLC). This proposal helps the CR (cloud requester/users) to trust their proprietary information and data stored in the cloud. © 2015 The Authors


Guruprakash K.S.,TRP Engineering College | Siva Sathya S.,Pondicherry UniversityPondicherry
International Journal of Applied Engineering Research | Year: 2015

With the advent of Cloud computing, the cloud has become the major service provider due to its inbuilt flexibilities and very low requirements. Effective usage of cloud can be made possible only when accurate parameters are provided during the configuration phase. But determining the appropriate parameters is not possible when migrating from web to cloud. This paper presents effective mechanisms that can be used to identify the parameter values using the data available from web logs. The framework begins from exploring and cleaning the data and proceeds by providing a simple use case of how attribute values can be extracted from the available data using clustering techniques from several dimensions. The final mapping phase also has several possibilities ranging from manual mapping to usage of machine learning algorithms and several Big Data tools. © Research India Publications.


Kumar S.A.,Pondicherry UniversityPondicherry | Shanmuganantham T.,Pondicherry UniversityPondicherry
Advances in Intelligent Systems and Computing | Year: 2014

In this paper, an implantable CPW-fed double-crossed-type triangular slot antenna mounted over human tissue is proposed for biomedical applications. The proposed antenna covers the ISM band of 2.45 GHz. The radiation parameters such as return loss, VSWR, Z-parameter are analyzed using the method of moments software (IE3D).The proposed antenna has substantial merits like miniaturization, lower return loss, and better impedance matching and high gain over other implanted antennas. © Springer India 2014.


Devi M.A.,Pondicherry UniversityPondicherry | Ravi S.,Pondicherry UniversityPondicherry | Vaishnavi J.,Pondicherry UniversityPondicherry | Punitha S.,Pondicherry UniversityPondicherry
Advances in Intelligent Systems and Computing | Year: 2016

Cervical cancer is a deadly cancer which occurs in women’s of all age group without any pre-symptoms. This cancer can be detected at the earliest by the manual screening of Pap smear test and LCB test which suffers from high false positive rate and cost effectiveness. To overcome this disadvantage an automatic computerised system is used to enhance the efficiency and sensitivity in the detection of cervical cancer. There are three types of tissues in the cervix region of uterus as Columnar Epithelium (CE), Squamous epithelium (SE) and the Aceto white (AW) region. The AW region, when immersed in 5% acetic shows a change of white colour as abnormal cervical cells. In this paper, a bio-inspired model is used for the automatic detection of cervical cancer where a support vector machine is used to classify the squamous cell carcinoma which will produce more accurate results by reducing the false positive rates. © Springer International Publishing AG 2016.


Rajan S.,Pondicherry UniversityPondicherry | Gazzali P.M.M.,Pondicherry UniversityPondicherry | Chandrasekaran G.,Pondicherry UniversityPondicherry
Journal of Alloys and Compounds | Year: 2016

Polycrystalline BaTiO3 doped with Fe and Mn (Ba1-xFexTi1-yMnyO3) is synthesized using the solid state reaction method. Structural, thermal, electrical and magnetic properties are discussed in the light of phase transitions. Structural studies establish the enhancement of lattice strain and disorderliness even at room temperature upon doping. The suppression of 308 cm-1 mode along with sustenance of Raman bands well above transition temperature is a consequence of the lattice shrinkage associated with increased micro-strain. Subsequently a decrement in ferroelectric to paraelectric phase transition temperature and associated enthalpy changes are also observed for Fe incorporated BaTiO3. The ferroelectric ordering is confirmed using P-E loop measurements. The magnetic studies reveal the prominent antiferromagnetic ordering in the sample. Improved magnetization results in the case of simultaneously substituted compounds over singly doped BaTiO3 due to the concurrent interaction between two magnetic A and B sublattices which is otherwise non magnetic. The present result is the first of its kind to report a Fe-Mn codoped BaTiO3 providing an ambient ferromagnetic and ferroelectric phase without losing the essence of either property. The cogent multiferroic property is need of the hour for enhancing functionalities for voltage driven non volatile multistate memory storage. © 2015 Elsevier B.V. All rights reserved.

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