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Morales-Morales C.,Polytechnic University of the State of Morelos | Rodriguez V.A.M.,Polytechnic University of the State of Morelos | Adam-Medina M.,CENIDET | Valdes L.G.V.,CENIDET
2016 IEEE International Autumn Meeting on Power, Electronics and Computing, ROPEC 2016 | Year: 2016

This paper presents the design of a system of faults detection and localization (its acronym FDI) based on a Piecewise Linear Observer implemented in F-16 fixed-wing aircraft under different regimes of flight: stable level wings, level turn, flight constant rising and roll. The scheme FDI based on observers that using to bank of linear observers for residues generation, switched by a switching law, dependent of time and the output of system. This piecewise linear state observer estimate the angular velocities of the aircraft. The dynamic model of the F-16 is considered as a set of linear models, linearized around of an operating point. The validation of the approach FDI is propose in simulation in conditions flight straight and level, which is one of the most important tasks of flying an aircraft while it is flying in the air. © 2016 IEEE.

PubMed | Polytechnic University of the State of Morelos, National Autonomous University of Mexico and Bielefeld University
Type: | Journal: Database : the journal of biological databases and curation | Year: 2016

The availability of databases electronically encoding curated regulatory networks and of high-throughput technologies and methods to discover regulatory interactions provides an invaluable source of data to understand the principles underpinning the organization and evolution of these networks responsible for cellular regulation. Nevertheless, data on these sources never goes beyond the regulon level despite the fact that regulatory networks are complex hierarchical-modular structures still challenging our understanding. This brings the necessity for an inventory of systems across a large range of organisms, a key step to rendering feasible comparative systems biology approaches. In this work, we take the first step towards a global understanding of the regulatory networks organization by making a cartography of the functional architectures of diverse bacteria. Abasy ( A: cross- BA: cteria SY: stems) Atlas provides a comprehensive inventory of annotated functional systems, global network properties and systems-level elements (global regulators, modular genes shaping functional systems, basal machinery genes and intermodular genes) predicted by the natural decomposition approach for reconstructed and meta-curated regulatory networks across a large range of bacteria, including pathogenically and biotechnologically relevant organisms. The meta-curation of regulatory datasets provides the most complete and reliable set of regulatory interactions currently available, which can even be projected into subsets by considering the force or weight of evidence supporting them or the systems that they belong to. Besides, Abasy Atlas provides data enabling large-scale comparative systems biology studies aimed at understanding the common principles and particular lifestyle adaptions of systems across bacteria. Abasy Atlas contains systems and system-level elements for 50 regulatory networks comprising 78 649 regulatory interactions covering 42 bacteria in nine taxa, containing 3708 regulons and 1776 systems. All this brings together a large corpus of data that will surely inspire studies to generate hypothesis regarding the principles governing the evolution and organization of systems and the functional architectures controlling them.Database URL:

PubMed | Polytechnic University of the State of Morelos, National Autonomous University of Mexico, Electric Research Institute of Mexico and Autonomous University of the State of Morelos
Type: | Journal: Bioinorganic chemistry and applications | Year: 2016

In this work we proposed to evaluate the corrosion resistance of four different alloys by electrochemical techniques, a binary alloy Cu10Al, and three ternary alloys Cu10Al-xAg (x = 5, 10, and 15wt.%) to be used like biomaterials in dental application. Biomaterials proposed were tested in artificial saliva at 37C for 48h. In addition, pure metals Cu, Al, Ag, and Ti as reference materials were evaluated. In general the short time tests indicated that the Ag addition increases the corrosion resistance and reduces the extent of localized attack of the binary alloy. Moreover, tests for 48 hours showed that the Ag addition increases the stability of the passive layer, thereby reducing the corrosion rate of the binary alloy. SEM analysis showed that Cu10Al alloy was preferably corroded by grain boundaries, and the Ag addition modified the form of attack of the binary alloy. Cu-rich phases reacted with SCN(-) anions forming a film of CuSCN, and the Ag-rich phase is prone to react with SCN(-) anions forming AgSCN. Thus, binary and ternary alloys are susceptible to tarnish in the presence of thiocyanate ions.

Larraraga-Moreno M.,Polytechnic University of the State of Morelos | Pineda-Mendez F.J.,International University of Mexico
IMSCI 2014 - 8th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings | Year: 2014

Innovation is a key element that shifts competitive advantages for enterprises not matter their size and activity. For small and medium enterprises (SME) the challenge is imperative, they have to acquire the ability to develop innovation and technology as a resource to develop their strategies and achieve goals. The Internet has become a virtual place where customers are sharing and communicating information about their experiences with the enterprises. One important tool that offers a platform to make this interaction is digital social networks. The SME sector in Mexico has an important participation in the economy of the country. Finding a model to improve the management of innovation and technology will allow giving this sector the opportunity to take advantage of the information and interactions that are taking place in digital social networks.

Freyre-Gonzalez J.A.,National Autonomous University of Mexico | Trevino-Quintanilla L.G.,Polytechnic University of the State of Morelos | Valtierra-Gutierrez I.A.,National Autonomous University of Mexico | Gutierrez-Rios R.M.,National Autonomous University of Mexico | Alonso-Pavon J.A.,National Autonomous University of Mexico
Journal of Biotechnology | Year: 2012

Escherichia coli and Bacillus subtilis are two of the best-studied prokaryotic model organisms. Previous analyses of their transcriptional regulatory networks have shown that they exhibit high plasticity during evolution and suggested that both converge to scale-free-like structures. Nevertheless, beyond this suggestion, no analyses have been carried out to identify the common systems-level components and principles governing these organisms. Here we show that these two phylogenetically distant organisms follow a set of common novel biologically consistent systems principles revealed by the mathematically and biologically founded natural decomposition approach. The discovered common functional architecture is a diamond-shaped, matryoshka-like, three-layer (coordination, processing, and integration) hierarchy exhibiting feedback, which is shaped by four systems-level components: global transcription factors (global TFs), locally autonomous modules, basal machinery and intermodular genes. The first mathematical criterion to identify global TFs, the κ-value, was reassessed on B. subtilis and confirmed its high predictive power by identifying all the previously reported, plus three potential, master regulators and eight sigma factors. The functionally conserved cores of modules, basal cell machinery, and a set of non-orthologous common physiological global responses were identified via both orthologous genes and non-orthologous conserved functions. This study reveals novel common systems principles maintained between two phylogenetically distant organisms and provides a comparison of their lifestyle adaptations. Our results shed new light on the systems-level principles and the fundamental functions required by bacteria to sustain life. © 2012 Elsevier B.V.

Garrido-Hoyos S.,Instituto Mexicano Of Tecnologia Del Agua | Romero-Velazquez L.,Polytechnic University of the State of Morelos
International Journal of Environmental Research and Public Health | Year: 2015

Arsenic has been classified as a toxic and carcinogenic chemical element. It therefore presents a serious environmental problem in different regions of the country and the world. In the present work, two adsorbent media were developed and evaluated to remove arsenic from water in the Pájaro Verde mine shaft, Huautla, Tlaquiltenango, Morelos. The media were synthesized and characterized, obtaining a surface area of 43.04 m2 g-1 for the goethite and 2.44 m2 g-1 for silica sand coated with Fe(III). To conduct the sorption kinetics and isotherms, a 23 factorial design was performed for each medium in order to obtain the optimal conditions for the factors of arsenic concentration, pH and mass of the adsorbent. The best results were obtained for goethite, with a removal efficiency of 98.61% (C0 of As(V) 0.360 mg L-1), and an effluent concentration of 0.005 mg L-1, a value that complies with the modified Official Mexican Standard NOM-127-SSA1-1994 [1] and WHO guidelines (2004) [2]. The kinetic equation that best fit the experimental data was the pseudo-second-order, resulting in the highest values for the constants for synthetic goethite, with a rate constant sorption of 4.019 g mg-1 min-1. With respect to the sorption isotherms, both media were fitted to the Langmuir-II linear model with a sorption capacity (qm) of 0.4822 mg g-1 for goethite and 0.2494 mg g-1 for silica sand coated with Fe(III). © 2015 by the authors; licensee MDPI, Basel, Switzerland.

Trevino-Quintanilla L.G.,Polytechnic University of the State of Morelos | Freyre-Gonzalez J.A.,National Autonomous University of Mexico | Martinez-Flores I.,National Autonomous University of Mexico
Current Genomics | Year: 2013

In bacteria, transcriptional regulation is a key step in cellular gene expression. All bacteria contain a core RNA polymerase that is catalytically competent but requires an additional σ factor for specific promoter recognition and correct transcriptional initiation. The RNAP core is not able to selectively bind to a given σ factor. In contrast, different σ factors have different affinities for the RNAP core. As a consequence, the concentration of alternate σ factors requires strict regulation in order to properly control the delicate interplay among them, which favors the competence for the RNAP core. This control is archived by different σ/anti-σ controlling mechanisms that shape complex regulatory networks and cascades, and enable the response to sudden environmental cues, whose global understanding is a current challenge for systems biology. Although there have been a number of excellent studies on each of these σ/anti-σ post-transcriptional regulatory systems, no comprehensive comparison of these mechanisms in a single model organism has been conducted. Here, we survey all these systems in E. coli dissecting and analyzing their inner workings and highlightin their differences. Then, following an integral approach, we identify their commonalities and outline some of the principles exploited by the cell to effectively and globally reprogram the transcriptional machinery. These principles provide guidelines for developing biological synthetic circuits enabling an efficient and robust response to sudden stimuli. ©2013 Bentham Science Publishers.

Moreno M.L.,Polytechnic University of the State of Morelos | Flores M.T.O.,Polytechnic University of the State of Morelos
IMSCI 2015 - 9th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings | Year: 2015

Small and medium enterprises (SME) are the most important economic units in Mexico and in Latin America. Due to this, it is important to generate new approaches that may allow us to find better strategies to promote their development and survival in actual markets. Latin-American SME's are in clear disadvantage when they are not able to overcome their competitiveness problems; economic growth will be slow, as will be structural changes. Most of SME's were originally created to satisfy their owners' need of employment; they usually don't have a formal organizational structure and their legal and taxing figure is not well defined. As expected, this has as a consequence limited access to financial resources. Regarding enterprises as complex adaptive systems enables us to understand that they share with SME's these model characteristics, which enable them to take advantage of their scarce resources and the prevailing market instability. SME cannot be isolated; they have the obligation to build relationships and interaction with their customers.

Guzman-Olea E.,National University of Costa Rica | Guzman-Olea E.,Polytechnic University of the State of Morelos | Bermudez-Morales V.H.,National University of Costa Rica | Peralta-Zaragoza O.,National University of Costa Rica | And 2 more authors.
Journal of Oncology | Year: 2012

Persistent infection with high-risk HPV is the etiologic agent associated with the development of cervical cancer (CC) development. However, environmental, social, epidemiological, genetic, and host factors may have a joint influence on the risk of disease progression. Cervical lesions caused by HPV infection can be removed naturally by the host immune response and only a small percentage may progress to cancer; thus, the immune response is essential for the control of precursor lesions and CC. We present a review of recent research on the molecular mechanisms that allow HPV-infected cells to evade immune surveillance and potential targets of molecular therapy to inhibit tumor immune escape. Copyright © 2012 E. Guzmn-Olea et al.

Pandarinath K.,National Autonomous University of Mexico | Dominguez-Dominguez H.,Polytechnic University of the State of Morelos
Journal of South American Earth Sciences | Year: 2015

A detailed study on the solute geothermometry of thermal water (18 springs and 8 drilled wells) of La Primavera geothermal field (LPGF) in Mexico has been carried out by employing a geochemical database compiled from the literature and by applying all the available solute geothermometers. The performance of these geothermometers in predicting the reservoir temperatures has been evaluated by applying a geochemometrics (geochemical and statistical) method. The springs of the LPGF are of bicarbonate type and the majority have attained partial-equilibrium chemical conditions and the remaining have shown non-equilibrium conditions. In the case of geothermal wells, water is dominantly of chloride-type and, among the studied eight geothermal wells, four have shown full-equilibrium chemical conditions and another four have indicated partial-equilibrium conditions. All springs of HCO3- type water have provided unreliable reservoir temperatures, whereas the only one available spring of SO42- type water has provided the reservoir temperature nearer to the average BHT of the wells. Contrary to the general expected behavior, spring water of non-equilibrium and geothermal well water of partial-equilibrium chemical conditions have indicated more reliable reservoir temperatures than those of partially-equilibrated and fully-equilibrated water, respectively. Among the chemical concentration data, Li and SiO2 of two springs, SO42- and Mg of four springs, and HCO3 and Na concentrations of two geothermal wells were identified as outliers and this has been reflected in very low reservoir temperatures predicted by the geothermometers associated with them (Li-Mg, Na-Li, Na-K-Mg, SiO2 etc.). Identification of the outlier data points may be useful in differentiating the chemical characteristics, lithology and the physico-chemical and geological processes at the sample locations of the study area.In general, the solute geothermometry of the spring waters of LPGF indicated a dominantly (94%) of underestimated deep reservoir temperatures, whereas in the case of the geothermal wells, many temperatures (54%) are underestimated, some are (43%) overestimated and a very small number (3%) are similar to an average bottom-hole temperatures (BHT) of the wells. 28 out of the total applied 29 geothermometers for spring waters have predicted the deep reservoir temperatures that are characterized by statistically significant large differences compared to the average BHTs of the geothermal wells. In the case of waters of the geothermal wells, 23 out of the total applied 28 geothermometers have predicted the reservoir temperatures similar (statistically no significant differences) to the BHTs of the corresponding geothermal wells. © 2015 Elsevier Ltd.

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