Polytechnic Institute of Leiria

Leiria, Portugal

The Polytechnic Institute of Leiria is a public institution of Higher Education that offers courses of training on an Undergraduate Degree, Masters, Post-Graduate, Technology Specialization and Preparation Courses for Access to Higher Education level. It began its activity in 1980 and is present in the Leiria and West region through its five schools, divided in five campus, located in the cities of Leiria , Caldas da Rainha and Peniche . IPL offers Undergraduate e Master Degrees courses in the areas of: Art and Design, Law studies, Education and Communication, Engineering and Technology, Tourism and Health. Wikipedia.

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Martins-Ferreira N.,Polytechnic Institute of Leiria
Applied Categorical Structures | Year: 2017

A detailed description of a normalized internal bicategory in the category of groups is derived from the general description of internal bicategories in weakly Mal’tsev categories endowed with a V-Mal’tsev operation in the sense of Pedicchio. The example of bicategory of paths in a topological abelian group is presented. © 2017 Springer Science+Business Media Dordrecht

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2012-IRSES | Award Amount: 168.00K | Year: 2012

Regenerative medicine (RM) is a critical need to establish in this century, in order to raise quality of life and reduce the cost of healthcare in our increasing aged populations. To do this there is a need for key research teams within and outside the EU to develop meaningful research collaborations and relationships at an institutional level. skelGEN brings together leading research institutions across disciplines in biology/engineering/computational modelling/orthopaedic research in the EU (UK, the Netherlands, Portugal) partnered with complementary experts in New Zealand. This collaboration will allow EU partner institutions to work in a coordinated way to address RM in the human skeleton, including bones, cartilage and tendons/ligaments. This work will range from basic science through to translational medicine and involves world experts, emerging scientists as well as young researchers. The programme of exchanges and knowledge transfer is built around four main scientific themes that will feed into each other, to pursue of skelGENs long term mission successfully. These themes are centred on stem cells, scaffolds and medical devices, computerised modelling and overall evaluation. Advances in stem cell therapy are required, such as pluripotent stem cells that do not have the political and ethical concerns of embryonic stem cell populations. Dynamic scaffolds need to respond to their environment and can integrate bioactive factors, using biocompatible biomaterials e.g. producing hybrid constructs of titanium rods and bulk polymers, self-assembling short peptides etc. to create better tissue/implant interfaces powerful for potential new therapies in RM. We plan to use computational modelling to assist in the tissue engineering of scaffolds and cells/tissues in vitro and in vivo. Finally we will endeavour to standardise the evaluation techniques used to assess the biocompatibility of these future medical devices.

Santos P.M.D.,Polytechnic Institute of Leiria | Julio E.N.B.S.,University of Lisbon
Construction and Building Materials | Year: 2013

Surface roughness plays an important role in the behavior of concrete-to-concrete interfaces. Methods like sand-blasting and hydrodemolition are usually adopted to improve the surface roughness of the concrete substrate. Before placing the new concrete layer it is common to verify the roughness level by visual inspection. However, this procedure can lead to inaccurate conclusions since it is influenced by the technician's opinion and, therefore, it is subjective. Current design codes of concrete structures implicitly propose this type of assessment since there is not a specified method or device to verify the conditions of the substrate surface. To overcome the drawbacks of this qualitative methodology, a quantitative approach should be adopted instead. Thus, it is necessary to measure the surface roughness and, from this, to compute roughness parameters. This paper presents a review on roughness quantification methods that can be adopted for concrete surfaces. © 2012 Elsevier Ltd. All rights reserved.

Santos P.M.D.,Polytechnic Institute of Leiria | Julio E.N.B.S.,University of Lisbon
Engineering Structures | Year: 2012

Initially proposed in 1966, the " shear-friction theory" has been adopted in all design codes to analyse concrete-to-concrete interfaces. In the last decades, several improvements were suggested to take into account more influencing factors, to increase the accuracy and to enlarge the application field. The inclusion of the concrete strength and density and the consideration of the dowel action are examples of the proposed improvements.This paper presents a literature review on design expressions for shear-friction, chronologically ordered, describing proposals from the earliest research studies, precursors of the theory, until the most recent studies, incorporated in the newest fib Model Code. The most significant contributions are identified and a comparison between some of these design expressions is presented. Codes updates concerning shear-friction provisions are also identified in the literature review herein presented. © 2012 Elsevier Ltd.

Domingues A.,University of Lisbon | Santos H.,Polytechnic Institute of Leiria | Costa M.,University of Lisbon
Energy | Year: 2013

This study evaluates the vehicle exhaust WHR (waste heat recovery) potential using a RC (Rankine cycle ). To this end, both a RC thermodynamic model and a heat exchanger model have been developed. Both models use as input, experimental data obtained from a vehicle tested on a chassis dynamometer. The thermodynamic analysis was performed for water, R123 and R245fa and revealed the advantage of using water as the working fluid in applications of thermal recovery from exhaust gases of vehicles equipped with a spark-ignition engine. Moreover, the heat exchanger effectiveness for the organic working fluids R123 and R245fa is higher than that for the water and, consequently, they can also be considered appropriate for use in vehicle WHR applications through RCs when the exhaust gas temperatures are relatively low. For an ideal heat exchanger, the simulations revealed increases in the internal combustion engine thermal and vehicle mechanical efficiencies of 1.4%-3.52% and 10.16%-15.95%, respectively, while for a shell and tube heat exchanger, the simulations showed an increase of 0.85%-1.2% in the thermal efficiency and an increase of 2.64%-6.96% in the mechanical efficiency for an evaporating pressure of 2 MPa. The results confirm the advantages of using the thermal energy contained in the vehicle exhaust gases through RCs. Furthermore, the present analysis demonstrates that improved evaporator designs and appropriate expander devices allowing for higher evaporating pressures are required to obtain the maximum WHR potential from vehicle RC systems. © 2012 Elsevier Ltd.

Santos P.M.D.,Polytechnic Institute of Leiria | Julio E.N.B.S.,University of Lisbon
ACI Materials Journal | Year: 2011

The bond strength of concrete-to-concrete interfaces, of reinforced concrete (RC) members with parts cast at different ages, is highly influenced by the curing conditions. Therefore, the monolithic behavior is dependent on these conditions. Current design codes only consider: a) the concrete compressive strength; b) the normal stress at the interface; c) the amount of reinforcement crossing the interface; and d) the roughness of the substrate surface. Because the curing conditions of both substrate and added concrete are ignored, the influence of the differential shrinkage is neglected. The influence of the differential stiffness due to the mismatch between the Young's modulus of both materials is not considered either. This paper presents an experimental study conducted to assess the influence of differential shrinkage and stiffness on the bond strength of new-to-old concrete interfaces. Both parameters were shown to have a significant influence on the bond strength and failure mode of concrete-to-concrete interfaces. Copyright © 2011, American Concrete Intitute. All rights reserved.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.2.2-1 | Award Amount: 13.20M | Year: 2013

Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects. Current cartilage implants cannot establish the hierarchical tissue organisation that appears critical for normal cartilage function. We hypothesise that a biomimetic zonal organisation is critical for implants to achieve cartilage regeneration. HydroZONES represents an interdisciplinary consortium that adopts a strategy to regenerate, rather than repair, articular cartilage based on the tissues zonal structure and function. HydroZONES will use advanced bioprinting technology for fabrication of 3D biofunctional hydrogel constructs, eventually mechanically reinforced by degradable polymer scaffolds, as biomimetic reconstitution of the zonal organisation of natural cartilage. Constructs will be optimized for cell-free application and also for combination with chrondrogenic cells (chondrocytes and/or MSC). Stringent in vitro and long term in vivo testing of the constructs will be employed that will yield a new clinical standard for pre-clinical testing. Cutting edge 3D tissue models and bioreactor technology will be used together with in silico modelling to develop a predictive in vitro assay and test system that will be validated against the in vivo data. Installation of a quality and regulatory affair management system, GMP production, accredited in vitro testing and involvement of clinical partners and companies with experience in clinical trials ensures that the best performing construct will be brought into an optimal position for entering clinical trials at project end. HydroZONES will thus advance the European Union as world leader in the field of joint cartilage regeneration.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: KBBE.2010.3.2-01 | Award Amount: 4.34M | Year: 2011

Innovation is the most important engine of growth and jobs in knowledge-based bio-economies. The scope of BAMMBO (Biologically Active Molecules of Marine Based Origin) is ambitious. This is intentional. BAMMBO will provide innovative solutions to overcome existing bottle-necks associated with culturing marine organisms in order to sustainably produce high yields of value-added products for the pharmaceutical, cosmetic and industrial sectors. BAMMBO will screen and identify target marine organisms (e.g. bacteria, fungi, sponges, microalgae, macroalgae and yeasts) from diverse global locations for potential as sustainable producers of highadded value molecules (HVABs). Our project will apply analytical methods for the extraction, purification and enrichment of targeted bioactive compounds. A detailed life cycle analysis of the production pathways developed in the project will be undertaken to fully evaluate the sustainability of production of biologically active products from marine organisms. BAMMBO will exploit knowledge and technologies developed during the project and effectively manage their transfer to relevant stakeholders in industry and the research community, as well as to policy-makers. We have brought together a multidisciplinary consortium of specialist Research and SME partners representing 8 countries including partners from ICPC countries Russia and Brazil, and from EU member states at Mediterranean, Adriatic and Atlantic coasts. In adhering to the European Strategy for Marine and Maritime Research this three year project will encourage capacity-building, integration and synergies across relevant marine sectors. Innovative technologies developed in the project will be demonstrated with the involvement of industry partners, and the results will be of interest not only to companies directly involved in the marine sector, but to other large scale industry players such as pharmaceutical companies with interest in added-value bioactive compounds.

Vasconcelos J.,Polytechnic Institute of Leiria
Environmental pollution (Barking, Essex : 1987) | Year: 2013

Mortality due to cardiovascular diseases shows a seasonal trend that can be associated with cold weather. Portugal is the European country with the highest excess winter mortality, but nevertheless, the relationship between cold weather and health is yet to be assessed. The main aim of this study is to identify the contribution of cold weather to cardiovascular diseases within Portugal. Poisson regression analysis based on generalized additive models was applied to estimate the influence of a human-biometeorological index (PET) on daily hospitalizations for myocardial infarction. The main results revealed a negative effect of cold weather on acute myocardial infarctions in Portugal. For every degree fall in PET during winter, there was an increase of up to 2.2% (95% CI = 0.9%; 3.3%) in daily hospital admissions. This paper shows the need for public policies that will help minimize or, indeed, prevent exposure to cold. Copyright © 2013 Elsevier Ltd. All rights reserved.

Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2009-IRSES | Award Amount: 745.20K | Year: 2010

During the last five to ten years, the healthcare sector is increasing its research activity, not only because final terminal cases are looking for solutions, but also diagnosis, treatment and life-long care are becoming ways to reduce costs of health care. Also, doctors and patients are constantly looking for better technologies in products such as orthopedic prosthesis, diagnostics, surgery instrumentation, drug dosing and delivery systems. In the meantime other maturing manufacturing systems with high level of knowledge (e.g. automotive manufacturing field) have been decreasing its research activity and well-developed technological advancements and solutions are not exploited as much as they can be in other fields. The main objective is to create and reinforce synergies between applied investigation fields of engineering and medicine in order to develop new solutions for the healthcare sector. The project will help in creating a high level expertise and understanding on Design, Prototyping and Manufacture for Medical Devices using computing tools, biomaterials and other biocompatible engineering materials. IREBID project is focused on developing novel and innovative medical devices, based on four big activities, Workshops (Seminars given by experts in medical field), Lecture (Short Senior Researcher Visit), Joint Research Projects (Collaboration between two or more partners) and Meetings. The expected result of the project is to develop solutions for the sector of biomedicine (new medical devices) and bioengineering such as, Development of coronary stents, devices which can slowly dose the medicine, improve existing developments, develop artificial joint replacements and orthopedic prosthesis, new optimized geometries and coatings for some invasive medical tools such as needles, scalpels and surgical tools and fabrication of functional graded scaffolds for tissue engineering.

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