Baltazar M.T.,University of Porto |
Baltazar M.T.,Advanced Institute of Health science North |
Dinis-Oliveira R.J.,University of Porto |
Dinis-Oliveira R.J.,Advanced Institute of Health science North |
And 6 more authors.
Pest Management Science
Background: Currently, the commercial formulations of the herbicide paraquat are highly toxic to humans, and no effective antidote is available for paraquat poisoning. The aim of the present study was to develop a safe formulation, combining paraquat and the known antidote lysine acetylsalicylate. The toxicity of a mixture of Gramoxone® (20% paraquat) and lysine acetylsalicylate in adult Wistar male rats and the herbicidal efficacy against grass lawn (50% of Poa pratensis and 50% of Festuca arundinacea) were evaluated. This new formulation was administered to Wistar rats by gavage at 125 mg kg-1 of paraquat ion and lysine acetylsalicylate at 79, 158 or 316 mg kg-1 body weight, and the survival rate was observed for 30 days. Results: The survival rate of the paraquat group was only 40%, while lysine acetylsalicylate provided effective protection, with full survival observed in the groups that received 125 mg kg-1 of paraquat ion and 316 mg kg-1 of lysine acetylsalicylate. Both formulations of paraquat, either in the absence or in the presence of lysine acetylsalicylate, provided the same herbicidal activity against the tested herbal species. Conclusions: The present formulation of paraquat containing lysine acetylsalicylate, significantly decreases mammalian toxicity while maintaining effective herbicidal activity. © 2012 Society of Chemical Industry. Source