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Chung H.-K.,Sungkyunkwan University | Shim H.-S.,Sungkyunkwan University | Jeon S.-H.,Polyscientech Inc. | Kim J.-H.,Sungkyunkwan University | And 3 more authors.
Polymer (Korea) | Year: 2015

The effects of chemical structure of alkyl groups of norbornene carboxylic alkyl esters(methyl, octyl, 4-chlo-robenzyl) and endo/exo ratios of norbornene monomers on activity of palladium catalyst and polymerization behavior were investigated. Norbornene ester monomers were synthesized from the reaction of 5-norborene-2-carboxylic acid and various alcohols. Polymerization catalyst, di-μ-chloro-bis(-methoxybicyclo[2, 2, 1]-hept-2-ene)palladium(II) (DCBMP), was synthesized according to the literature procedure and silver hexafluoroantimonate (AgSbF6) was used as a conjugate anion source. Gel permeation chromatography (GPC), thermogravimetric analysis (TGA), differential scanning cal-orimetry (DSC) were the principal techniques for polymer characterization and 1H NMR spectroscopy was used for chemical structures determination of monomers and polymers. For all of the norbonene alkyl esters GPC data showed that when the amounts of endo isomers exceeded those of exo isomers decreased molecular weight polymers were obtained probably due to the decreased catalyst activity. Polymerizations were conducted by varying the monomer/catalyst mole ratios (100:1, 200:1, 300:1). When 300:1 monomer/catalyst ratio was employed it was possible to synthesize high molecular weight (Mn=27500 g/mol), film forming polymer from exo-norbornene carboxylic acid octyl ester. © 2015 The Polymer Society of Korea. All rights reserved.


Park K.H.,Sungkyunkwan University | Park C.K.,Polyscientech Co. | Park J.,Polyscientech Co. | Jeon S.,Polyscientech Co. | And 3 more authors.
Polymer (Korea) | Year: 2014

PVC (polyvinyl chloride) intravenous fluid bags and tubes that contain DEHP (diethylhexyl phthalate) as a plasticizer have several associated disadvantages for intravenous injections. We investigated the drug absorption behaviors on the inner surface of an infusion tube that consisted of commercialized PVC/PU (polyurethane). We developed a non-PVC (polyolefin) tube in order to improve the efficacy of this drug administration method. We prepared four types of non-PVC (polyolefin) infusion tubes using a polyethylene (PE), polypropylene (PP), syndiotactic 1,2-polybutadiene (PB), and styrene-ethylene (SE) copolymer elastomers were prepared using a single screw extruder. The four types of manufactured non-PVC (polyolefin) infusion tubes had good mechanical properties that were equivalent to PVC tube properties. The four types of prepared non-PVC (polyolefin) infusion tubes also prohibited drug absorption when compared to the commercialized PVC and PU tubes. Therefore, based on the results of this study, prepared non-PVC (polyolefin) tubes are good candidates for infusion because they prevent drug absorption and the release of DEHP.


Provided is a medical tube including at least one layer made of a composition containing a cross-copolymerized olefin-aromatic vinyl compound-diene copolymer. The medical tube according to the present invention, which has excellent kink resistance, toughness, transparency, non-adsorption of drugs, and the like, and is made of a non-toxic polyvinyl chloride (PVC)-free material, may be combined with an injection-molded article of the resin, the resultant article may be effectively used for medical supplies such as an infusion set, a blood transfusion set, a medical liquid container set, a medical catheter, and the like.


Provided is a medical tube including at least one layer made of a composition containing a cross-copolymerized olefin-aromatic vinyl compound-diene copolymer. The medical tube according to the present invention, which has excellent kink resistance, toughness, transparency, non-adsorption of drugs, and the like, and is made of a non-toxic polyvinyl chloride (PVC)-free material, may be combined with an injection-molded article of the resin, the resultant article may be effectively used for medical supplies such as an infusion set, a blood transfusion set, a medical liquid container set, a medical catheter, and the like.


PubMed | Yonsei University and Polyscientech Co.
Type: Journal Article | Journal: International journal of pharmaceutics | Year: 2016

Diazepam is highly sorbed to the plastic materials of administration sets for intravenous infusion. This can be detrimental as it should be delivered to the patient at the administered amount for efficacy and safety. We report here the sorption levels of diazepam onto various types of tubes in administration sets. The tube materials of the administration sets included polyvinylchloride (PVC) and the non-PVC materials such as polyurethane (PU) and polyolefin (PO) were used. Two conditions of diazepam administered in preclinical and clinical settings were tested using an infusion pump. Injections were prepared by diluting diazepam to 20mg/500mL and 10mg/100mL in 5% dextrose. Diluted diazepam solutions at the concentrations of 10mg/100mL and 20mg/500mL were separately delivered through 1m of tubing at 1mL/min for 1.05 and 4.05h. Samples were analyzed using a high-performance liquid chromatography with UV detection. PVC- and PU-based tubes showed higher sorption of diazepam than did PO-based tubes. PO-based tubes delivered more than 90% of the administered diazepam. The results showed that PO-based tubes of administration sets have a promising potential to deliver hydrophobic drugs like diazepam with minimal sorption levels. In addition, the tube materials in administration sets may be one of the critical factors to ensure drug efficacy and safety.

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