Allschwil, Switzerland
Allschwil, Switzerland

Time filter

Source Type

Patent
Polyphor Ltd. and University Zuerich | Date: 2016-12-28

Template-fixed -hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These -hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid and solution phase synthetic strategy.


Patent
University Zuerich and Polyphor Ltd. | Date: 2016-12-15

The template-fixed -hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-^(D)Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-^(D)-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity


Template-fixed -hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties These -hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.


Patent
Polyphor Ltd. and University of Zürich | Date: 2016-06-01

Template-fixed -hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These -hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.


Patent
University Zuerich and Polyphor Ltd. | Date: 2014-02-07

Template-fixed -hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These -hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.


Patent
University Zuerich and Polyphor Ltd. | Date: 2014-02-07

Template-fixed -hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These -hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.


Patent
Polyphor Ltd. | Date: 2013-12-19

Template-fixed -hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 4 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to agonize or to antagonize GPCR receptors such as CXCR3, urotensin and CCR10. They can be used as medicaments to treat or prevent diseases such as cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, inflammatory diseases, neurological diseases, respiratory diseases, haematological diseases and cancer. These -hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.


Patent
University Zuerich and Polyphor Ltd. | Date: 2014-11-28

The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-^(D)Pro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-^(D)-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity


Patent
University of Zürich and Polyphor Ltd. | Date: 2013-12-09

Template-fixed -hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These -hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.


Patent
University Zuerich and Polyphor Ltd. | Date: 2013-11-07

Template-fixed -hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 -amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These -hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

Loading Polyphor Ltd collaborators
Loading Polyphor Ltd collaborators