Polymeric Materials Group for the Controlled Release of Bioactive Compounds in Biomedicine

Madrid, Spain

Polymeric Materials Group for the Controlled Release of Bioactive Compounds in Biomedicine

Madrid, Spain
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Blanco M.D.,Polymeric Materials Group for the Controlled Release of Bioactive Compounds in Biomedicine | Guerrero S.,Polymeric Materials Group for the Controlled Release of Bioactive Compounds in Biomedicine | Benito M.,Polymeric Materials Group for the Controlled Release of Bioactive Compounds in Biomedicine | Fernandez A.,Polymeric Materials Group for the Controlled Release of Bioactive Compounds in Biomedicine | And 4 more authors.
Polymers | Year: 2011

Folate-targeted poly[(p-nitrophenyl acrylate)-co-(N-isopropylacrylamide)] nanohydrogel (F-SubMG) was loaded with 5-fluorouracil (5-FU) to obtain low (16.3 ± 1.9 μg 5-FU/mg F-SubMG) and high (46.8 ± 3.8 μg 5-FU/mg F-SubMG) load 5-FU-loaded F-SubMGs. The complete in vitro drug release took place in 8 h. The cytotoxicity of unloaded F-SubMGs in MCF7 and HeLa cells was low; although it increased for high F-SubMG concentration. The administration of 10 μM 5-FU by 5-FU-loaded F-SubMGs was effective on both cellular types. Cell uptake of F-SubMGs took place in both cell types, but it was higher in HeLa cells because they are folate receptor positive. After subcutaneous administration (28 mg 5-FU/kg b.w.) in Wistar rats, F-SubMGs were detected at the site of injection under the skin. Histological studies indicated that the F-SubMGs were surrounded by connective tissue, without any signs of rejections, even 60 days after injection. Pharmacokinetic study showed an increase in MRT (mean residence time) of 5-FU when the drug was administered by drug-loaded F-SubMGs. © 2011 by the authors.

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