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Lodi Vecchio, Italy

Matos L.M.C.,Federal University of Rio de Janeiro | Leal I.C.R.,Polo Universitario | De Souza R.O.M.A.,Federal University of Rio de Janeiro
Journal of Molecular Catalysis B: Enzymatic

Diacylglycerols (DAG) are commonly used in different purity levels for food, medicine and cosmetic industries. Several approaches are found over the literature on DAG production under lipase-catalyzed reactions among which are highlighted: glycerol sterification, vegetable oils' glycerolysis and selective hydrolysis. Results obtained palm oil partial hydrolysis catalyzed by PS Amano IM under microwave irradiation show that DAG can be produced through short-term reactions and moderated yields (5 min, 30%). The DAG production using packed bed reactors under conventional heating and continuous flow conditions is more efficient allowing us to produce 128 g in 24 h with flow rate as a key feature. © 2011 Elsevier B.V. Source

Gill J.L.,Roslin Institute | Bishop S.C.,Roslin Institute | McCorquodale C.,Roslin Institute | Williams J.L.,Polo Universitario | Wiener P.,Roslin Institute
Meat Science

The aim of this study was to evaluate the effects of 28 single nucleotide polymorphisms (SNP) in 10 candidate genes previously shown to be associated with quality traits in pigs and cattle. The data set comprised 28 traits recorded on a commercial population of 536 Aberdeen Angus-cross beef cattle. Among the traits, 20 were carcass and sirloin quality related, one mechanical measure of tenderness, and the remaining seven were taste panel assessed sensory traits. The candidate genes studied included growth hormone (GH) and pro-opiomelanocortin (POMC). Association analysis showed that 13 of the 28 SNPs were significantly associated with at least one of the traits. Some of these were novel (POMC and mechanical tenderness), whilst others confirmed previous results (GH and eye muscle length).Following validation in other populations and breeds, these markers could be incorporated into breeding programs to increase the rate of improvement in carcass and meat quality traits. © 2010 The American Meat Science Association. Source

Leach R.J.,Roslin Institute | Leach R.J.,U.S. Department of Agriculture | O'Neill R.G.,Fisheries and Food | Fitzpatrick J.L.,Moredun Research Institute | And 3 more authors.

Infectious disease is an important problem for animal breeders, farmers and governments worldwide. One approach to reducing disease is to breed for resistance. This linkage study used a Charolais-Holstein F2 cattle cross population (n = 501) which was genotyped for 165 microsatellite markers (covering all autosomes) to search for associations with phenotypes for Bovine Respiratory Syncytial Virus (BRSV) specific total-IgG, IgG1 and IgG2 concentrations at several time-points pre- and post-BRSV vaccination. Regions of the bovine genome which influenced the immune response induced by BRSV vaccination were identified, as well as regions associated with the clearance of maternally derived BRSV specific antibodies. Significant positive correlations were detected within traits across time, with negative correlations between the pre- and post-vaccination time points. The whole genome scan identified 27 Quantitative Trait Loci (QTL) on 13 autosomes. Many QTL were associated with the Thymus Helper 1 linked IgG2 response, especially at week 2 following vaccination. However the most significant QTL, which reached 5% genome-wide significance, was on BTA 17 for IgG1, also 2 weeks following vaccination. All animals had declining maternally derived BRSV specific antibodies prior to vaccination and the levels of BRSV specific antibody prior to vaccination were found to be under polygenic control with several QTL detected. Heifers from the same population (n = 195) were subsequently immunised with a 40-mer Foot-and-Mouth Disease Virus peptide (FMDV) in a previous publication. Several of these QTL associated with the FMDV traits had overlapping peak positions with QTL in the current study, including the QTL on BTA23 which included the bovine Major Histocompatibility Complex (BoLA), and QTL on BTA9 and BTA24, suggesting that the genes underlying these QTL may control responses to multiple antigens. These results lay the groundwork for future investigations to identify the genes underlying the variation in clearance of maternal antibody and response to vaccination. © 2012 Leach et al. Source

Duarte J.P.,Polo Universitario
Thin-Walled Structures

This paper formalizes the domain of all and only manufacturable open cold-formed steel (CFS) profiles aimed at improving their strength capability in the development of new products. A Genetic Algorithm is applied over this domain to get a set of best solutions from structural and constructive viewpoints. A basic review is carried out with regard to (i) Shape Grammar, (ii) Finite Strip Method-based elastic buckling analysis, (iii) Direct Strength Method-based structural strength computation and (iv) modified procedure of the Non-dominated Sorting Genetic Algorithm. CFS-manufacturing is defined as a language and its general grammar is presented. This grammar-based model responds to requisites of descriptive power, simplicity of implementation, and customization to specific needs. The CFS grammar has been implemented using scripting languages available in pre-existing CAD and CAE applications. Implementation includes generation, visualization, analysis and improvement capabilities. Results show that innovative shapes with improved strength could be generated from the finite set of allowable manufacturing grammar rules encoded by the grammar. © 2014 Elsevier Ltd. Source

Asero R.,Ambulatorio di Allergologia | Casalone R.,Polo Universitario | Iemoli E.,Allergy and Clinical Immunology Unit
European Annals of Allergy and Clinical Immunology

A case of immediate and definitive response to a single dose of omalizumab in a child with severe ciclosporin-resistant chronic urticaria is reported. Source

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